Dr. Dale Bredesen explains how inflammation, toxins, and metabolic dysfunction drive Alzheimer’s—and how a systems approach may help reverse cognitive decline.

Dr. Dale Bredesen discusses a new systems-based understanding of Alzheimer’s disease, explaining how cognitive decline emerges from a network imbalance in the brain. In conversation with Dr. Richard Horowitz, he explores how mitochondrial dysfunction, inflammation, infections, toxins, and metabolic issues contribute to neurodegeneration—and why addressing multiple root causes simultaneously may help improve cognitive health.

Dr. Dale Bredesen is a neuroscientist and internationally recognized expert in neurodegenerative diseases, including Alzheimer’s disease. A graduate of Caltech and Duke University School of Medicine, he has published more than 200 scientific papers on the mechanisms of neurodegeneration. His work focuses on identifying the root causes of cognitive decline and developing comprehensive, personalized strategies aimed at preventing and reversing Alzheimer’s disease.