Coffee consumption is associated with protection from several chronic diseases, including cancer, cardiovascular disease, and neurodegenerative disease. Whereas some of the beneficial effects of coffee may stem from its ability to induce autophagy, other evidence points to the benefits of caffeine, which, when consumed early in the morning – resets the body's internal clocks and provides a mental boost that helps us start the day and may even protect telomeres. But the long half-life of caffeine can reduce sleep quality, fueling a vicious cycle of poor sleep, daytime grogginess, and increased caffeine consumption. This Aliquot segment features Dr. Guido Kroemer, an expert in immunology, cancer biology, aging, and autophagy; Dr. Satchin Panda, an expert in circadian rhythm research; Dr. Matthew Walker, a professor of neuroscience and psychology; Dr. Elissa Epel, an expert in telomere biology; and Dr. Rhonda Patrick (in an interview with Mike Maser).

• (00:00) Introduction
• (02:13) The class of compounds known as "caloric restriction mimetics" that affect autophagy (Guido Kroemer discussion)
• (11:04) Time-restricted feeding and coffee (Satchin Panda discussion)
• (18:06) The impact of diet on telomere length (Elissa Epel discussion)
• (19:31) Coffee in the evening reduces deep sleep by about 20 percent (Matthew Walker discussion)
• (21:58) The autophagy-enhancing effect of coffee (Guido Kroemer discussion)
• (23:41) Amount of caffeine in breastmilk (Rhonda Patrick discussion)

You can see the original full interview with Dr. Kroemer You can see the original full interview with Dr. Panda You can hear the original full interview with Dr. Rhonda Patrick and Mike Maser You can see the original full interview with Dr. Epel You can see the original full interview with Dr. Walker

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