In this episode of Should You Take This?, host Joe Cohen dives deep into Lactobacillus rhamnosus GG (L. Rhamnosus GG)—one of the most researched probiotic strains for gut health, brain function, and heart health.

Joe shares his megadosing experiment, where he took 375 billion CFU of L. Rhamnosus in one day—25x the standard dose—to test its effects on mood, cognition, digestion, and cardiovascular health. 

He breaks down the scientific research behind Lactobacillus rhamnosus, explaining how it can:

✔ Reduce excess glutamate and increase GABA, leading to improved mood and mental clarity✔ Lower TMAO levels, a metabolite linked to heart disease risk✔ Strengthen the gut barrier, improving digestion and immune function

He also explores the genetic link, explaining how SelfDecode flagged L. Rhamnosus as a top recommendation based on his unique DNA risks for neurotransmitter imbalance, inflammation, and metabolic health.

If you’re wondering whether Lactobacillus rhamnosus is the right probiotic for you, this episode breaks down the real-world benefits, genetic considerations, and optimal ways to take it.

- Check out SelfDecode: https://selfdecode.com/

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