In this episode of the PCOS Repair Podcast, you'll discover how targeted nutritional supplementation can help reduce oxidative stress and improve hormone and metabolic function in women with PCOS. This discussion is based on a recent research article titled The Effects of Nutritional Supplementation on Oxidative Stress and Hormonal and Lipid Profiles in a PCOS-Affected Female. If you’ve been wondering whether certain nutrients—like vitamin D or omega-3s—can actually help with PCOS symptoms, this episode breaks it down in a practical and research-backed way.

Oxidative Stress and PCOS

Oxidative stress is a type of internal cellular stress caused by an imbalance between free radicals and antioxidants in the body. It’s not the kind of stress you feel emotionally, but rather the kind that leads to cellular damage and accelerates aging. In PCOS, oxidative stress is particularly concerning because it contributes to insulin resistance, increased androgens, chronic inflammation, and even fertility issues. It can also impair egg quality and affect ovulation, adding another layer of complexity for women trying to conceive.

Oxidative Stress Biomarkers (Labs)

This research highlights a few key biomarkers to assess oxidative stress levels, including malondialdehyde (MDA), total antioxidant capacity (TAC), glutathione (GSH), and nitric oxide (NO). Each of these indicators can help reveal the degree of oxidative damage in the body and how effectively your systems are working to counteract it. In women with PCOS, these markers are often out of balance, showing both elevated oxidative damage and diminished antioxidant defense.

Supplements That Help Reduce Oxidative Stress

This episode explores several key nutrients that play a powerful role in reducing oxidative stress for women with PCOS. These nutrients help lower inflammation, support metabolic function, and improve insulin sensitivity—all of which are essential for hormone balance. Some have been shown to lower testosterone levels and enhance the body’s ability to manage blood sugar, while others support thyroid health and overall inflammation regulation. Some nutrients promote gut health, which is closely tied to hormone regulation, and even those that support better sleep while offering antioxidant benefits that may positively influence fertility. One of the most exciting findings from this study is the suggestion that certain nutrients can influence how genes express themselves. Some support IGF-1 levels, which are important for egg development and ovulation, while others impact insulin sensitivity through specific genetic pathways. There’s also evidence that certain nutrients may reduce the expression of genes involved in chronic inflammation. While more research is needed, this emerging science highlights the potential for nutrition to make meaningful changes at a cellular level.

Supplements in Your PCOS Strategy

No one supplement will fix PCOS, but using the right nutrients can significantly reduce oxidative stress and improve hormone function. As always, quality matters. Choose third-party tested brands and remember that supplements should complement, not replace, lifestyle interventions.

If you're looking for trusted supplement recommendations, you can download the free PCOS The Supplement Guide. I’ve included a list of high-quality brands and tips for getting started. 

Improving oxidative stress through nutrition is a powerful tool for managing PCOS. From fertility to energy levels to long-term hormone balance, this episode offers a fresh perspective on what’s possible with the right support.

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