What if your Premature Ovarian Insufficiency (POI) wasn't just about your ovaries but about your immune system turning against them?

Most women with POI are told it's simply early menopause. The conversation stops at hormone replacement or donor eggs. But new research shows that for many women, POI has autoimmune roots. When that's the case, treatment, prognosis, and even pregnancy potential all look very different.

In this episode, we explore how the immune system can drive POI, the red flags most doctors miss, and which labs uncover what's really happening inside your body. You'll also hear how a functional fertility approach can calm immune dysfunction and support natural ovarian activity.

You'll learn:

• The latest evidence connecting autoimmunity and Premature Ovarian Insufficiency

• Red flags that suggest POI may be immune-driven rather than purely ovarian

• The key labs to request for thyroid, gut, and immune system assessment

• Why conventional HRT isn't enough and how bioidentical hormones fit in

• Functional fertility strategies that support hormone balance and ovarian function

Sarah Clark is the founder of Fab Fertile Inc. and the host of Get Pregnant Naturally. Her team specializes in functional approaches for low AMH, high FSH, diminished ovarian reserve, premature ovarian insufficiency, recurrent miscarriage and helping couples prepare their bodies for pregnancy success naturally or with IVF.

This episode is for you if:

• • You've been diagnosed with POI, low AMH, or high FSH and want to understand what's driving it

  • You or your family have autoimmune conditions like thyroid disease, celiac, type 1 diabetes, or lupus

  • You've had irregular cycles, miscarriages, or failed IVF transfers, and feel like something deeper is being missed

Not sure where to start? Download our most popular resource: The Ultimate Guide to Getting Pregnant This Year If You Have Low AMH/High FSH. It breaks everything down step by step to help you understand your options and take action.

For personalized support to improve pregnancy success, book a call here.

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TIMESTAMPS

00:00 – What if POI isn't just early menopause? Why many women are misdiagnosed and how autoimmunity can drive premature ovarian insufficiency.

02:00 – Conventional vs. functional fertility approaches to POI How standard care stops at HRT or donor eggs, while functional fertility looks at what's really driving ovarian decline.

04:00 – Understanding POI beyond the ovaries How deeper health issues like immune, thyroid, and gut imbalances can affect ovarian function and fertility potential.

06:00 – The autoimmune patterns seen in women with low AMH and high FSH How family history, Hashimoto's, and other immune clues point to systemic dysfunction.

09:00 – Key labs to explore beyond AMH and FSH Why thyroid, antibodies, and gut testing reveal what routine fertility tests miss.

12:00 – Why you must advocate for deeper testing How to push for immune and inflammatory markers like ANA and hs-CRP when conventional medicine overlooks them.

15:00 – Gut health, inflammation, and leaky gut in POI The link between microbiome imbalance, gluten sensitivity, and ovarian autoimmunity.

18:00 – Nutrient and metabolic markers that affect ovarian function Vitamin D, ferritin, B12, folate, and homocysteine. What optimal levels mean for egg quality and implantation.

21:00 – Understanding HRT and bioidentical hormones for POI Why bioidentical estrogen and progesterone support heart, bone, and reproductive health more effectively than synthetics.

24:00 – Functional fertility action plan for autoimmune POI How to test deeper, calm the immune system, and improve fertility outcomes naturally or with IVF.

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RESOURCES

Stop Ignoring hsCRP and the Role of Inflammation in Diminished Ovarian Reserve: https://fabfertile.com/blogs/podcasts/stop-ignoring-hscrp-and-the-role-of-inflammation-in-diminished-ovarian-reserve?_pos=1&_sid=82deaccd1&_ss=r

Get Pregnant Naturally with Low AMH, Diminished Ovarian Reserve or POF: (Sarah's Story) https://fabfertile.com/blogs/podcasts/get-pregnant-naturally-with-low-amh-diminished-ovarian-reserve-or-pof?_pos=15&_sid=86a653303&_ss=r

Is Your Thyroid Impacting Egg Health? The Hidden Connection to Low AMH, DOR & Fertility Success: https://fabfertile.com/blogs/podcasts/is-your-thyroid-impacting-egg-health-the-hidden-connection-to-low-amh-dor-fertility-success?_pos=6&_sid=81c11854e&_ss=r

How Iron Deficiency Impacts Fertility, Egg Quality & Low AMH: https://fabfertile.com/blogs/podcasts/ferritin-iron-deficiency-fertility-low-amh-high-fsh?_pos=1&_sid=5bce72a22&_ss=r

Why Addressing Homocysteine Levels Can Boost Egg and Sperm Health: https://fabfertile.com/blogs/podcasts/why-addressing-homocysteine-levels-can-boost-egg-and-sperm-health?_pos=1&_sid=b235d5698&_ss=r

Autoimmune Roadblocks to IVF: How ANA Affects Fertility: https://fabfertile.com/blogs/podcasts/autoimmune-roadblocks-to-ivf-how-ana-affects-fertility?_pos=1&_sid=d10e6427f&_ss=r

The Clotting Connection: Hidden Causes of Implantation Failure and Miscarriage: https://fabfertile.com/blogs/podcasts/the-clotting-connection-hidden-causes-of-implantation-failure-and-miscarriage?_pos=1&_sid=82f26ca56&_ss=r

Our favorite fertility tracker Inito (use code FABFERTILE15 to save 15)

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💛 Join my free Facebook group: Get Pregnant Naturally With Low AMH and/or High FSH: https://www.facebook.com/groups/451444518397946

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Please note we only promote products that Sarah Clark or her Fab Fertile team has tried and believes are beneficial for someone who is TTC. We may receive a small commission.