Dr. Henry Mahncke reveals how an NIH-funded study showed brain training reversed brain aging markers by 10 years, why speed-based training is uniquely effective, and the future of brain health interventions.

Dr. Henry Mahncke, CEO of Posit Science and creator of BrainHQ, discusses the groundbreaking INHANCE study that used PET scans to show brain training can reverse brain aging by 10 years. In this wide-ranging conversation, Dr. Mahncke explains how their adaptive brain training exercises increase acetylcholine—a crucial neurochemical that declines with age and is depleted in Alzheimer's disease. He addresses common criticisms of brain training, explaining why speed and accuracy training is fundamentally different from memorization exercises, and shares surprising insights including why Tom Brady uses brain training. We discuss optimal dosing (30 minutes daily works well), the role of sleep in brain plasticity, supplementation with compounds like phosphatidylcholine, and whether this should be a lifelong practice. Dr. Mahncke makes the case that we're at the beginning of a "brain health revolution" where maintaining cognitive function should be as routine as physical exercise

🌐Links in this video

Brain HQ website https://www.brainhq.com/ The trial on clinical trials https://clinicaltrials.gov/study/NCT04149457 Effects of Computerized Cognitive Training on Vesicular Acetylcholine Transporter Levels using [18F]Fluoroethoxybenzovesamicol Positron Emission Tomography in Healthy Older Adults: Results from the Improving Neurological Health in Aging via Neuroplasticity-based Computerized Exercise (INHANCE) Randomized Clinical Trial https://games.jmir.org/2025/1/e75161

Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO

AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw

https://www.choosemuse.com

Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)

Renue by Science all 10% discount with code MHS https://renuebyscience.com/

Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN

If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan