Christian Drosten returns to TWiV to provide an update on the COVID-19 situation in Germany, and general thoughts on testing, immunity, vaccines, therapeutics, epidemiology, reopening schools, and what will happen this fall.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Christian Drosten

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Links for this episode

• Christian previously on TWiV 601
• Plague percolation phenomenon (Nature)
• TMPRSS2 inhibitor for SARS-CoV-2 (Cell)
• Repeated infections with endemic CoV (J Inf Dis)
• Koch Institute SARS-CoV-2 reports
• Letters read on TWiV 659
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

Daniel Griffin provides a clinical report on COVID-19, then we discuss CDC softening testing guidelines, Moderna vaccine phase I results in older people, Abbott's $5 rapid antigen test, and reinfection with a distinct SARS-CoV-2 isolate, followed by listener email.

Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, and Rich Condit

Guest: Daniel Griffin

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Links for this episode

• CDC told to soften SARS-CoV-2 testing guidelines (NYTimes)
• Moderna investor presentation on mRNA-1273 vaccine (link)
• SARS-CoV-2 reinfection (Clin Inf Dis)
• Dr. Fauci talks with just about anyone (NYTimes)
• Letters read on TWiV 658
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Immunologist Shane Crotty joins TWiV to discuss the antibody and T cell responses to infection with SARS-CoV-2, followed by answers to listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Shane Crotty

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Links for this episode

• Ahead of the Curve by Shane Crotty
• SARS-CoV-2 T cell epitopes (Cell)
• Cross-reactive CoV T cell epitopes (Science)
• Knowns and unknowns about SARS-CoV-2 immunity (Nat Rev Imm)
• Letters read on TWiV 657
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

Daniel Griffin provides a clinical report on COVID-19, surgeons Lisa Smith and David Bruce detail how they have helped their Chattanooga community during the pandemic, then we discuss racial and ethnic disparities among COVID-19 cases, no more premarket review of laboratory developed tests by FDA; and emergency use authorization of convalescent plasma is on hold.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

Guests: Daniel Griffin, Lisa A. Smith, and W. David Bruce

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Links for this episode

• Racial and ethnic disparities in workplace COVID-19 (CDC)
• Rescission of guidances on laboratory tests (FDA)
• EUA on convalescent plasma on hold (NY Times)
• Letters read on TWiV 656
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

Sociomedical scientist Robert Fullilove joins TWiV to discuss disparities in minority health; FDA announces an EUA on Yale's SalivaDirect, protection of the upper and respiratory tract of mice after intranasal inoculation with an adenovirus-vectored SARS-CoV-2 spike gene, and listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Robert Fullilove

Click arrow to play Download TWiV 652 (69 MB .mp3, 114 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV!

Links for this episode

• Health of racial and ethnic minority groups (CDC)
• COVID-19 death/hospitalization by race/ethnicity (CDC)
• Racial and ethnic disparities in workplace COVID-19 (CDC)
• SalivaDirect EUA (FDA)
• Adenovirus vectored SARS-CoV-2 experimental vaccine protects mice (Nat Comm)
• Letters read on TWiV 655
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

Daniel Griffin provides a clinical report on COVID-19 and the convalescent plasma trial, then we answer listener questions about the Russian vaccine, choir practice, face masks (wear them!), Mina testing, transmission, and much more.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Chuck Knirsch

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Alfonso, Ken, Mary and Janet join TWiV to explain their modeling of school reopening strategies during the SARS-CoV-2 pandemic.

Hosts: Vincent Racaniello and Rich Condit

Guests: Alfonso Landeros, Ken Lange, Mary E. Sehl, and Janet Sinsheimer

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Links for this episode

• School reopening strategies (medRxiv)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Epidemiologist Adam Kucharski joins TWiV to discuss SARS-CoV-2, including R0, incubation period, herd immunity, asymptomatic infection, superspreaders, children as drivers of pandemics, and how this one will end.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Adam Kucharski

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Links for this episode

• The Rules of Contagion (Amazon affiliate link)
• Overdispersion in SARS-CoV-2 transmission (Wellcome Open Res)
• Sorrento Therapeutics test
• In vitro diagnostics EUAs (FDA)
• Letters read on TWiV 652
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Daniel Griffin provides a clinical report on COVID-19, then former FDA Chief of Staff to the Commissioner Denise Esposito joins us to explain the challenges in approving vaccines, antiviral drugs, and diagnostic tests during a pandemic, followed by answers to listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Denise Esposito

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Links for this episode

• Template for at-home, OTC diagnostic tests (FDA)
• Postdoctoral position in Prasad laboratory (pdf)
• Rapidtests.org
• Masks are cool, Miasma t-shirts (CafePress)
• Letters read on TWiV 651
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In this mid-week episode of Earth's Virology Podcast, we analyze SARS-CoV-2 transmission among youths at a summer camp, adaptation to mice by passage, the importance of T cells for recovery from COVID-19, and listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• Travis County indicators dashboard
• SARS-CoV-2 transmission at an overnight camp (MMWR)
• Adaptation of SARS-CoV-2 in mice (Science)
• Acute SARS-CoV-2 infection impairs DC and T cell responses (Imm)
• Boulder, Columbia, Illinois rapid saliva tests
• Letter drafts for $1 testing
• Letters read on TWiV 650
• Timestamps by Jolene. Thanks!

Weekly Science Picks

KathyBBC Witness History, Maurice Hilleman 9 minute audio (quotes by Paul Offit) “The fastest vaccine ever developed”And APOD Picture Rocks Sun Dagger

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]