Vincent visits Ohio State University (March 2020) and speaks with Shan-Lu, David, Amanda, Mark, Matt, Chris, and Qiuhong about their careers and their work on retroviruses, hepatitis C virus, coronaviruses, paramyxoviruses, and environmental viruses.

Host: Vincent Racaniello

Guests: Shan-Lu Liu, David Bisaro, Amanda Panfill, Mark Peeples, Matt Sullivan, Chris Walker, Qiuhong Wang

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Links for this episode

• New virus requires international control (Nature)
• TIM-family proteins inhibit HIV-1 release (PNAS)
• Designing a HCV vaccine (Curr Op Virol)
• Attenuated vaccines for RSV in children (J Inf Dis)
• Plant histone reader suppresses geminivirus infection (J Virol)
• HTLV-associated malignancy (Curr Op Virol)
• Coronaviruses in pigs (Curr Op Virol)
• Marine DNA viral diversity pole to pole (Cell)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Daniel Griffin provides a clinical report on COVID-19, followed by a review of the findings that children shed as much SARS-CoV-2 viral RNA from the respiratory tract as older patients, the lineage giving rise to SARS-CoV-2 has been circulating in bats in China for decades, and answers to listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Daniel Griffin and Chuck Knirsch

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Links for this episode

• Roche trial of Actemra for COVID-19 fails (Reuters)
• Postdoctoral position at RML
• Shedding of SARS-CoV-2 at different ages (JAMA Ped)
• Evolutionary origins of SARS-CoV-2 (Nat Microbio)
• Letters read on TWiV 648
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In this mid-week TWiV, children under 10 do transmit SARS-CoV-2, why hydroxychloroquine does not work for treating COVID-19, scale-up of diagnostic testing, explanation of LAMP testing, and listener questions.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Links for this episode

• Children do transmit infection (Emerg Inf Dis)
• NIH RADx initiative (NEJM)
• Rockefeller Foundation testing plan
• HCQ observational study (Int J Inf Dis)
• Can't kill HCQ (Science Based Medicine)
• HCQ does not inhibit SARS-CoV-2 in human lung cells (Nature)
• HCQ does not inhibit SARS-CoV-2 in nonhuman primates (Nature)
• Shut-down to stop SARS-CoV-2 (WaPo)
• Racine firefighters doing LAMP (Wired)
• LAMP (video, webinar, paper 1, paper 2)
• Letter drafts for $1 testing
• Letters read on TWiV 647
• Timestamps by Jolene. Thanks!

Kathy - Vertical Farms Fill a Tall Order by Dickson Despommier and APOD Rich - Mars in 4K

Christiane - ZSK - Ich habe Besseres zu tun (Official Video) Drosten Jon - The Logic of Doomsday

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

From the NIH campus (recorded February 2020) Vincent and Rich meet with Eugene Koonin to discuss his theories on the evolutionary origins of viruses.

Hosts: Vincent Racaniello and Rich Condit

Guest: Eugene Koonin

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Links for this episode

• Virocentricity with Eugene Koonin (TWiV 275)
• Origin of viruses (Nat Rev)
• Multiple origins of capsid proteins from cells (PNAS)
• Origins and evolution of global RNA virome (mBio)
• Evolution of NCLDV of eukaryotes (Adv Virus Res)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Daniel Griffin provides a clinical report on COVID-19, followed by a review of the State Department document on the Wuhan BSL-4 laboratory, the report on infection of tigers and lions in the Bronx Zoo, and, answers to listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Daniel Griffin

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Links for this episode

• State Dept. memo on Wuhan BSL-4 lab (pdf)
• Biosafety levels (Wikipedia)
• Inside a BSL-4 (TWiV)
• From people to panthers (bioRxiv)
• Letters read on TWiV 645
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In this mid-week edition, identifying flawed research before it becomes dangerous, Michigan governor tells America to mask-up, Pfizer mRNA vaccine gets $1.95 billion from Warp Speed, preliminary phase I/II results of the ChAdOx1 SARS-CoV-2 vaccine, answers to listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Click arrow to play Download TWiV 644 (69 MB .mp3, 115 min) Subscribe (free): iTunes, Google Podcasts, RSS, email

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Links for this episode

• US COVID-19 cases (NY Times)
• Identify flawed research before it is dangerous (NY Times)
• Mask up, America! (NY Times)
• $1.95 billion to Pfizer (NY Times)
• Phase I trial of Pfizer mRNA vaccine (medRxiv)
• Phase I/II trial of ChAdOx1 vaccine (Lancet)
• Rockefeller Foundation testing plan
• TWiV 640 on MedCram
• Letter drafts for $1 testing
• Letters read on TWiV 644
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

From the NIH campus (recorded February 2019) Vincent and Rich meet with Bernie Moss to hear about his training and his remarkable 50-year-plus career working on poxviruses.

Hosts: Vincent Racaniello and Rich Condit

Guest: Bernie Moss

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Link for this episode

• Reflections on Bernie Moss' career (JBC)

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Daniel Griffin provides a clinical update on COVID-19, then we discuss phase I preliminary results of the SARS-CoV-2 mRNA vaccine, factors associated with death in 17 million patients, and answer listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Chuck Knirsch

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Links for this episode

• Travis County virtual Town Hall
• SARS-CoV-2 mRNA vaccine, preliminary results (NEJM)
• Factors associated with COVID-19 death (Nature)
• Letters read on TWiV 642
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Dr. Anthony Fauci joins TWiV to discuss SARS-CoV-2 transmission, testing, immunity, pathogenesis, vaccines, and preparedness.

Hosts: Vincent Racaniello and Rich Condit

Guest: Dr. Anthony Fauci

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Dr. Fauci was previously on TWiV 219

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Michael Mina joins TWiV to reveal why frequent and rapid SARS-CoV-2 testing is more important than accuracy, how a daily $1 rapid test could control the pandemic, and why group testing works.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guests: Michael Mina

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Links for this episode

• Michael Mina on Immune 26
• White House bypasses CDC (NY Times)
• Test sensitivity is secondary to frequency and turnaround time (medRxiv)
• Group testing for SARS-CoV-2 (medRxiv)
• Consider the cycle threshold value (Clin Inf Dis)
• MERS-CoV spike nanoparticles protect mice from infection (Vaccine)
• CoV spike protein nanoparticles induce neutralizing antibodies in mice (Vaccine)
• Letters read on TWiV 640
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]