Daniel Griffin provides a clinical update on COVID-19, including analysis of the dexamethasone trial, and then we discuss two Ebolavirus outbreaks in DRC, clinical and virological aspects of asymptomatic SARS-CoV-2 infections, age-dependent effects on transmission, and answer listener email.

Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove

Guests: Daniel Griffin and Chuck Knirsch

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Links for this episode

• Dexamethasone reduces COVID-19 deaths (U Oxford)
• Assessment of asymptomatic COVID-19 (Nature Med)
• Age-dependent effects on SARS-CoV-2 transmission (Nature Med)
• Image credit
• Letters read on TWiV 629
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Vincent and Rich discuss the SARS-CoV-2 D614G amino acid change in the spike glyprotein, duration of infectious virus shedding from patients, virus transmission among hamsters infected in the laboratory, and tackle listener email.

Hosts: Vincent Racaniello and Rich Condit

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Links for this episode

• Austin TX key indicators for staging
• D614 amino acid change (Scripps)
• Virus shedding in hospitalized patients (medRxiv)
• Hamster SARS-CoV-2 model (Nature)
• COVID-19 host genetic initiative
• Image credit
• Letters read on TWiV 628
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Vincent visits the National Centre for Infectious Diseases and speaks with Executive Director Leo Yee-Sin and Consultant Nancy Tee about the main hub for both clinical treatment of infectious diseases and outbreak management in Singapore.

Host: Vincent Racaniello

Guests: Leo Yee-Sin and Nancy Tee

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Links for this episode

• National Centre for Infectious Diseases
• National Public Health Laboratory

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Daniel Griffin provides a clinical update on COVID-19, then Ralph Baric joins TWiV to discuss SARS-CoV-2 transmission, vaccines, diagnostic tests, and a new animal model from his laboratory that does not use transgenic mice.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin, Chuck Knirsch, and Ralph Baric

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Links for this episode

• Mouse-adapted SARS-CoV-2 model (bioRxiv)
• SARS-CoV-2 mRNA vaccine (bioRxiv)
• ASM resources for #shutdownstem
• President Obama on sustaining momentum for change (Facebook)
• America After the Civil War (PBS)
• Image credit
• Letters read on TWiV 626
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Vincent and Rich visit Fred Murphy to hear about his wide-ranging career in virology, spanning many institutions, involving dangerous viruses like rabies virus, Ebolavirus (he took that famous iconic image), Marburg virus, Lassa virus, coronaviruses, and later writing a history of the field.

Hosts: Vincent Racaniello and Rich Condit

Guest: Frederick A. Murphy

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Link for this episode

• (UTMB)

Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

Daniel Griffin provides a clinical update on COVID-19, then Sabra Klein joins us to discuss the effect of sex, gender, and age on viral infectious disease, including COVID-19.

Hosts: Vincent Racaniello,Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker

Guests: Daniel Griffin, Chuck Knirsch, and Sabra Klein

Click arrow to play Download TWiV 624 (91 MB .mp3, 152 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV!

Links for this episode

• SeXX matters in infectious disease pathogenesis (PLoS Path)
• Sex and gender impact immune responses to vaccines (Physiol)
• Testosterone and disease severity in mice (Cell Immunol)
• Age-associated effects on impact of sex steroids on vaccine responses (NPJ Vaccines)
• Evolution of greater humoral immunity in females (Curr Opin Physiol)
• Impact of sex and gender on COVID-19 (Biol Sex Diff)
• COVID-19 trials should include sex as variable (J Clin Inves)
• Global Health 50/50
• Image credit
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Peter Daszak joins TWiV to explain the work of EcoHealth Alliance in surveillance of bats in China for SARS-related coronaviruses to provide the information needed to prevent future pandemics, and why NIH recently withdrew financial support for their work.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Peter Daszak

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Links for this episode

• Bats are reservoirs of SARSr-CoV (Science)
• Bat SARSr-CoV that binds ACE2 (Nature)
• Rich gene pool of bat SARSr-CoV (PLoS Path)
• Bat SARSr-CoV infect humans (Virol Sin)
• Transmission of bat SARSr-CoV in China (bioRxiv)
• Global Virome Project (Science)
• ASV Virtual Workshops 2020
• Image credit
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

Emmie de Wit joins TWiV to explain her work on the pathogenesis of infection with SARS-CoV-2 in rhesus macaques, including studies on remdesivir and vaccine candidate.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Emmie de Wit

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Links for this episode

• Respiratory disease in macaques inoculated with SARS-CoV-2 (Nature)
• Clinical benefit of remdesivir in SARS-CoV-2 infected macaques (bioRxiv)
• Remdesivir for MERS-CoV infection in macaques (PNAS)
• ChAdOX1 vaccination for SARS-CoV-2 in macaques (bioRxiv)
• Image credit
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Daniel Griffin provides a clinical update on COVID-19, then we review an Ad5 vectored SARS-CoV-2 vaccine, reports on remdesivir and hydroxychloroquine, a drug repurposing study, why some patients infect many others, reducing viral transmission, and much more, including listener email.

Hosts: Vincent Racaniello,Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker

Guests: Daniel Griffin and Chuck Knirsch

Subscribe (free): iTunes, Google Podcasts, RSS, email

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Links for this episode

• Safety of Ad5 vectored COVID-19 vaccine (Lancet)
• Analysis of hydroxychloroquine use (Lancet)
• Remdesivir study (NEJM)
• Ancient COVID-19 history (MMWR)
• Drug repurposing for COVID-19 (bioRxiv)
• Why do few COVID-19 patients infect others? (Science)
• Overdispersion in COVID-19 transmission (Wellcome Open Res)
• Reducing airborne transmission (Science)
• Letters read on TWiV 621
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

Jon Yewdell returns to explain studies on detection of antibodies and T cell epitopes in patients who have recovered from COVID-19.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Jon Yewdell

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• T cell targets in COVID-19 patients (Cell)
• SARS-CoV-2 seroconversion in humans (Nat Med)
• Convergent antibody responses to SARS-CoV-2 infection (bioRxiv)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]