Doris Cully joins TWiV to discuss inhibition of SARS-CoV-2 in cell culture by ivermectin, followed by continuing analysis of the coronavirus pandemic caused by SARS-CoV-2 including COVID-19 in Nadia the tiger, and prediction of respiratory failure by levels of IL-6.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

Guest: Doris Cully

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• Ivermectin inhibits SARS-CoV-2 in cell culture (Antiviral Res)
• Tiger at NY zoo positive for SARS-CoV-2 (NY Times)
• IL-6 level predicts respiratory failure in COVID-19 patients (medRxiv)
• Infection fatality rate for managing pandemic (virology blog)
• Image credit
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Daniel Griffin MD returns to TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, followed by our coverage of the coronavirus pandemic caused by SARS-CoV-2.

Hosts: Vincent Racaniello, Dickson Despommier,Rich Condit, and Kathy Spindler

Guest: Daniel Griffin, MD

Download TWiV 598 (70 MB .mp3, 115 min) Subscribe (free): iTunes, Google Podcasts, RSS, email

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• Restricted dispensing of Plaquenil in NY state
• Virology of COVID-19 patients (Nature)
• Susceptibility of domestic animals to SARS-CoV-2 (bioRxiv_
• Cloth face masks for all of US (NY Times)
• Masks and respiratory virus shedding (Nat Med)
• 50 million face masks to Japanese households (Kyodo News)
• More than you want to know about face masks (Slate Star Codex)
• Why is COVID-19 less severe in children? (virology blog)
• Tracking SARS-CoV-2 in sewage (UM)
• 1918 flattening the curve (Nat Geo)
• COVID near you
• Pandemic stops polio eradication (Science)
• SARS-CoV-2 vaccine patch in mice (U Pitt)
• Letters read on TWiV 595
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

Immunologist Jon Yewdell joins Vincent and Rich to discuss immune responses in the context of infection with SARS-CoV-2.

Hosts: Vincent Racaniello and Rich Condit

Guest: Jon Yewdell

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Intro music is by Ronald Jenkees.

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TWiV covers trials of hydroxychloroquine and convalescent plasma therapy for COVID-19, and answers listener questions on blood tests for antibodies, cross-protection among coronaviruses, acquiring infection from food or the gas pump, face masks containing copper, and much more.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

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• Emergency use of hydroxychloroquine (FDA)
• Trial of hydroxycholorquine in COVID-19 patients (China, France)
• COVID-19 in critically ill patients, Seattle (NEJM)
• Feasibility of convalescent plasma therapy for COVID-19 (medRxiv)
• Letters read on TWiV 596
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

Daniel Griffin MD joins TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, and then the TWiV team continues coverage of the coronavirus pandemic caused by SARS-CoV-2.

Hosts: Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Daniel Griffin, MD

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• Tocilizumab (Wiki)
• Nares swab for SARS-CoV-2 (Star Trib)
• US SARS-CoV-2 epidemic curve (CDC)
• Cleaning and disinfecting (CDC)
• Cleaning fruits and vegetables (FDA)
• Coronavirus food safety (FDA)
• Vaccine development for SARS-CoV-2 (pdf)
• Image by Michele Banks
• Letters read on TWiV 595
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

Ian Lipkin joins Vincent to talk about his experience as a COVID-19 patient, and issues surrounding the disease and SARS-CoV-2 including limiting transmission, antivirals, vaccines, and much more.

Hosts: Vincent Racaniello

Guest: W. Ian Lipkin

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• Center for Infection and Immunity
• Control the Contagion videos
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Pediatric infectious disease physician and coronavirologist Mark Denison joins Vincent for a discussion of COVID-19 and SARS-CoV-2 with an emphasis on antiviral therapeutics.

Hosts: Vincent Racaniello

Guest: Mark Denison

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Intro music is by Ronald Jenkees.

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A TWiV foursome provides an update on the SARS-CoV-2 pandemic, including antibody testing kits, FDA emergency approval of convalescent sera, and answer listener questions about the dangers of mail delivery and take out foods, decontamination of PPE, diagnostic testing, and much more.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

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• Coronavirus test kit
• Rapid SARS-CoV-2 serological assay (medRxiv)
• Is Dr. Fauci in trouble? (NY Times)
• FDA approves emergency use of convalescent serum (FDA)
• Image by Michele Banks
• Letters read on TWiV 594
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

Daniel Griffin joins Ori and the TWiV team an update on the SARS-CoV-2 pandemic, including gastrointestinal illness associated with infection, use of hydroxychloroquine and other antivirals, his experiences treating many patients in the New York area, and much more.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guests: Daniel Griffin, Ori Lieberman, and Valeria Cagno

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• Pregnancy and COVID-19 papers (1, 2, 3, 4, 5)
• Second dog infected with SARS-CoV-2 (ProMedMail)
• Italian site with infographic in English
• Image by Michele Banks
• Letters read on TWiV 593
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Ori joins TWiV for an update on the SARS-CoV-2 pandemic, including scary modeling, clinical trials for antivirals and vaccines, asymptomatic transmission, and much more inspired by listener email.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Guest: Ori Lieberman

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• Scary modeling (Imperial College London)
• Avigan vs SARS-CoV-2 (NHK)
• SARS-CoV-2 mRNA vaccine (Clinical Trials)
• SARS-CoV-2 stability (NEJM)
• Pediatric COVID-19 (one, two)
• SARS-CoV-2 asymptomatic infection (one, two)
• CDC data on SARS-CoV-2 CFR (MMWR)
• Hydroxycholorquine trial for COVID-19 (Mediterranee-infection)
• Macaque SARS-CoV-2 immunity (bioRxiv)
• Image by Michele Banks
• Letters read on TWiV 591
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]