Coronavirus expert Ralph Baric joins TWiV to explain the virology and epidemiology of the recent zoonotic outbreak spreading across China and overseas.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove,Rich Condit, Kathy Spindler

Guest: Ralph Baric

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Links for this episode

• ASV 2020
• WHO coronavirus sitreps
• CIDRAP article on coronavirus vaccines
• Phylogenetic analysis of 2019-nCoV
• ACE2 is 2019-nCoV receptor (bioRxiv)
• Visual explainer of Huanan market (SCMP)
• Clinical features of 2019-nCoV patients (Lancet)
• Familial cluster of pneumonia caused by 2019-nCoV (Lancet)
• SARS-CoV 29 nt deletion reduces replication (Sci Rep)
• NSABB
• 2019 TWiV World Tour t-shirt
• Letters read on TWiV 584
• Timestamps by Jolene. Thanks!

Weekly Science Picks

Alan - Library plug-in for Firefox or Chrome Rich - Sounds of the Solar Wind (Parker Solar Probe) Dickson - Stunning wildlife photos Kathy - Incomplete list of things that blow the minds of intro bio students Vincent - Mosquito photographs by Alex Wild (and anti-pick)

Listener Pick

Justin - YadaYadaYada virus

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

Vincent and Rich travel to Galveston National Laboratory to speak with Jim LeDuc, Tom Ksiazek, and Bob Tesch about their long careers as virus hunters.

Hosts: Vincent Racaniello and Rich Condit

Guests: Jim LeDuc, Tom Ksiazek, and Bob Tesh

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Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV provides updates on the new coronavirus causing respiratory disease in China, the current influenza season, and the epidemic of African swine fever, including determination of the three-dimensional structure of the virus particle.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

Download TWiV 582 (71 MB .mp3, 118 min) Subscribe (free): iTunes, Google Podcasts, RSS, email

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Links for this episode

• ASV 2020
• NJ ready to remove religious vaccine exemptions (Patch)
• New virus causing pneumonia in China (NY Times)
• New China virus is coronavirus (NY Times, ProMedMail)
• Weekly influenza cases (CDC)
• Future of influenza vaccines (Vaccines)
• Household influenza vaccine study (Int J Epidemiol)
• African swine fever (USDA)
• African swine fever infographics (one, two)
• Race for African swine fever vaccine (Scientist)
• 3D structure of African swine fever virus (J Biol Chem)
• Letters read on TWiV 582
• Timestamps by Jolene. Thanks!

Weekly Science Picks

Rich - Mayo Clinic - Ken Burns; Patient Care and Health Information Dickson - Australia Fires; Insect ecology; Smoke and aerosols Kathy - runcible Vincent - Without a Vaccine, These Are Your Odds

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

For the first TWiV of 2020 we reveal that microbiome depletion with antibiotics alters the immune response to influenza vaccine, and how successive blood meals facilitate virus dissemination in mosquitoes and transmission potential.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Links for this episode

• ASV 2020
• Vaccines are safe and effective (Science)
• Microbiome perturbation alters response to flu vaccine (Cell)
• Successive blood meals aid virus dissemination in mosquitoes (Nat Micro)
• Letters read on TWiV 581
• Timestamps by Jolene. Thanks!

Weekly Science Picks

Brianne - Retrovirus cookie cutter! (and Phage, Adenovirus, Rabies virus, and Antibody Alan - "Yah! Yah! Yah!" by Jack London, and the true story it's based on Dickson - Why whales are big but not bigger Kathy - Dual Axis Illusion Vincent - The Fall of the Faculty  by Benjamin Ginsberg

Listener Pick

Suellen - Patient Zero podcast

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

From the University of Texas at Austin, Vincent and Rich speak with Chris Sullivan about his work on miRNAs encoded in the genomes of polyomaviruses and papillomaviruses, and how an RNA triphosphatase restricts hepatitis C virus replication.

Hosts: Vincent Racaniello and Rich Condit

Guest: Chris Sullivan

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Links for this episode

• Sullivan lab
• Virus-encoded miRNAs in papillomaviruses (PLoS Path)
• Murine polyomavirus miRNA promotes viruria (J Virol)
• DUSP11 helps XRN restrict hepatitis C virus (PNAS)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

Vincent speaks with virologists at the University of Nevada at Reno about their careers and their work on herpesviruses, arboviruses, and the development of diagnostics for infectious diseases.

Host: Vincent Racaniello

Guests: Dave AuCoin, Cyprian Rossetto, Claudia Rückert, and Subhash Verma

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Links for this episode

• PAN's labyrinth (Viruses)
• KSHV SOX protein DNAse activity (J Virol)
• Vertical flow immunoassay for pathogen detection (Talanta)
• Small RNA responses of mosquitoes (Insect Biochem Mol Biol)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

Vincent speaks with members of Prometheus, a team of academic and industrial scientists assembled to develop antibody-based therapeutics against infections caused by tick-borne Crimean-Congo hemorrhagic fever virus and rodent-borne hantaviruses, for which no approved vaccines or specific drugs are available.

Host: Vincent Racaniello

Guests: Kartik Chandran, Zachary Bornholdt, Steven Bradfute, John Dye, Matthias Forsell, Jason McLellan, Laura Walker, and Cecelia Vial.

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Links for this episode

• NIH U19 grant mechanism
• $22 million Prometheus grant
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

Vincent speaks with Félix Rey about his career and his work on solving structures of a variety of viruses and the insights learned about viral membrane fusion and antibody-mediated neutralization.

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Links for this episode

• Unité de Virologie Structurale
• Tick-borne encephalitis glycoprotein structure (Nature)
• HCV RNA polymerase structure (PNAS)
• Flavivirus structural heterogeneity (Curr Op Viral)
• Antibody responses to flaviviruses (EMBO Rep)
• Covalently linked dengue envelope dimers (Nat Comm)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

From the 22nd meeting of the European Society for Clinical Virology in Copenhagen, Vincent speaks with Thea, Heli, Kim, Caroline and Irma about big data and its increasing use in virology diagnostics, epidemiology, and public health.

Host: Vincent Racaniello

Guests: Thea Kølsen Fischer, Kim Benschop, Caroline Brown, Heli Harvala, and Irma Salimovic-Besic

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Links for this episode

• 22nd ESCV meeting
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

From the Fourth Symposium on Giant Virus Biology in Germany, Vincent, Rich, and Nels speak with Assaf, Stephen, and Alexandra about their careers and their work on giant viruses that infect ocean hosts: Emiliana huxleyi, Aureococcus anophagefferans, and a choanoflagellate.

Hosts: Vincent Racaniello, Rich Condit, and Nels Elde

Guests: Assaf Vardi, Stephen Wilhelm, and Alexandra Worden

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Links for this episode

• 4th Ringberg Symposium on Giant Virus Biology
• In-plaque mass spectrometry imaging (Nature Micro)
• Infection by brown tide virus, AaV (Front Micro)
• Choano virus with a rhodopsin photosystem (PNAS)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]