Dr. Austin Perlmutter explains how optimizing brain metabolism, immunity, and neuroplasticity can extend brain healthspan and longevity.

Dr. Austin Perlmutter reframes longevity through the lens of brain health, explaining why cognitive function, mood, and decision-making are the true foundations of a long and meaningful life. He explores how brain metabolism, neuroinflammation, and neuroplasticity interact to shape aging, mental health, and dementia risk—and shares practical ways to optimize brain healthspan through exercise, nutrition, sleep, and lifestyle choices.

Dr. Austin Perlmutter is a board-certified internal medicine physician, a New York Times Bestselling Author, and a researcher. He received his medical degree from the University of Miami and completed his internal medicine residency at Oregon Health and Science University. His focus is on helping identify and resolve the biological basis for “stuckness” in the body and brain using lifestyle interventions, and he lectures internationally on this subject. He hosts the Get The STUCK OUT podcast and is a co-producer of the Alzheimer’s, the Science of Prevention Docu-series. His work on immune-mediated depression can be found in the peer-reviewed medical literature. His writing is featured online on MedPage Today, Doximity, KevinMD, Medium, Psychology Today, and MindBodyGreen. He currently serves as the Senior Director of Science and Clinical Innovation at Big Bold Health.