In this episode of the *Innovations and Clinical Implementation* podcast recorded at LongevityFest, hosts Tom Blue and Chris D'Adamo discuss the rapid evolution of epigenetic testing with Ryan Smith. Ryan Smith is the founder and global head of research and development at TruDiagnostic, a CLIA-certified lab and health data company that has built one of the world's largest private epigenetic databases to advance the measurement of biological aging. The discussion traces the 140% year-over-year growth in consumer interest regarding biological age and explores how TruDiagnostic utilizes AI to interpret over 1.3 million DNA methylation sites to validate longevity interventions in clinical trials. Smith previews the upcoming release of "methylation risk scores" that can predict the onset of diseases like COPD and Lyme disease, and details the development of "Epigenetic Biomarker Proxies" (EBPs) intended to eventually replace traditional labs by deriving thousands of metrics—such as HbA1c, CRP, and environmental toxins—from a single finger stick.

For access to episode resources, click HERE.