Vitamin D Deficiency and Impaired Fat Loss: new research and insights

02.13.2022 - By High Intensity Health with Mike Mutzel, MS

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New research suggests Vitamin D influences the structure and function of fat cells and may even impact how much body fat is stored and released to be burned as energy. Save on one of the best Vitamin D3 and K2 blends MYOXCIENCE Nutrition: Save with code podcast at checkout At-home Vitamin D blood spot test: Link to video, images and science: ----------------------Show Notes---------------- 0:00 Intro 00:26 Vitamin D is sequestered in fat tissue. 00:30 Vitamin D influences your metabolism 00:58 Vitamin D insufficiency causes a dysregulation within your fat cells, 01:30 vitamin D cutaneous synthesis. 02:25 Vitamin D in adipose (fat) tissue affects, 02:40 When you are overweight and obese, your fat cells become necrotic, and they can die. 03:22 The active form of vitamin D 04:30 Vitamin D exerts significant effects on the formation of fat cells (adipogenesis). 05:00 Sufficient levels active metabolites of vitamin D suppress the accelerated adipogenesis, shown in animal and cellular models. 06:00 Vitamin D2 VS vitamin D3 07:00 Vitamin D3 (Cholecalciferol) is acquired from your food or sun exposure. Food sources are fatty fish, dairy, ruminants, the flesh/skin of vertebrae animals, egg yolks and dietary supplements. 08:10 Vitamin D5, sitocalciferol, is derived from an Ayurvedic herb called Rauwolfia serpentina. 09:05 Your liver is responsible for hydroxylating pre-vitamin D into the somewhat active form, calcidiol. This is what is measured in your blood, 25-hydroxy vitamin D. 09:20 Either your fat cells or your kidney further hydroxylates it into 125-dihydroxy vitamin D, calcitriol, is the active form. 09:55 The conversion from 25-hydroxy vitamin D to the 125 dihydroxy vitamin D is down regulated In fat cells, particularly in overweight people. 12:09 Vitamin D activates the vitamin D receptor. Generally, vitamins are cofactors. Vitamin D receptor is found in your fat tissue, kidney, muscle, and bone. When it is activated, it effects your immune system, calcium homeostasis and binding and many inflammatory pathways. 12:55 The vitamin D receptor impacts lipolysis, the release of lipids from your fat cells for energy. 13:18 Your fat tissues store between 35 and 75% of your total body levels of vitamin D. 13:46 People who have diabetes or insulin resistance or are obese, there is less fat cell turnover, which releases vitamin D that was stored in fat cells. So less vitamin D is released to the resto of the body. 14:00 Vitamin d deficiency is 35 to 40% higher in overweight or obese people, or diabetics. 14:30 Vitamin D impacts many functions within the fat cell, including the upregulation of fat cell creation. 15:08 Lipid accumulation decreases with increasing calcitriol (125-dihydroxy vitamin D) dosages. 15:40 Fat cell inflammation is mediated by leptin. 16:40 Chronic activation of immune system cells can trigger inflammation in obesity related pathogenesis in which insulin resistance is involved. 17:03 Nuclear factor-kappa B (NF-kappa B) transcription factor triggers inflammatory cascades within your cells. Vitamin D can inhibit this NF-kappa B activation. 17:30 Overweight or obese individuals have a higher prevalence of vitamin D insufficiency. 18:00 Dosing of supplemental vitamin D should be based upon body fat and health status. 18:23 Vitamin D impacts calcium metabolism. The balance of calcium affects apoptosis, preprogrammed cell death. 19:35 Serum vitamin D levels 20:00 Exercise helps to promote fat cell health and metabolism. It can mobilize fat cell lipids. Flux of fat cells is healthy. Fasting also promotes a healthy churn of your fat tissue. 22:00 With supplemental vitamin D, there are reductions in fasting glucose, hemoglobin A1C, and increases in triglycerides, improving metabolic health. *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.  

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