We consider hypoxia inducible factor's muscular response to high intensity exercise before going more in depth in its effects with the next episodes. We break down high intensity training, defining hypoxia vs anaerobic, then dive into a study that investigates its main effects in high intensity execise, as well as individual variation in training response. Plus a couple practical tips for considering this pathway in training, as well as a peek at the adaptive tradeoffs we'll see in future episodes.