Well Beyond 40

"Aging gracefully? More like defying it altogether. I’m aiming for a 30-year-old body with a 300-year-old mind." - Dr. Jeff Gladden

In this episode of Well Beyond 40, I sit down with Dr. Jeff Gladden, a renowned interventional cardiologist turned longevity expert, to unravel the secrets of turning 100 into the new 30. Dr. Gladden shares his personal journey of overcoming midlife health challenges that many of us can relate to—exhaustion, weight gain, and the looming threat of mental decline. But instead of accepting these as signs of inevitable aging, he cracked the code to reclaiming his vitality and has since dedicated his life to helping others do the same.

Dr. Gladden’s approach to longevity isn’t just about avoiding decline; it’s about optimizing every aspect of your health, from your genetics to your daily habits. He dives deep into the science behind why some of us age faster than others, how personalized nutrition and exercise can make a world of difference, and the game-changing role of bio-identical hormone therapy—especially crucial for women navigating menopause. His insights on the exponential nature of aging and how to combat it with comprehensive, customized strategies will make you rethink everything you thought you knew about getting older.

But the real magic happens when Dr. Gladden talks about regeneration—the future of anti-aging. Imagine resetting your biological clock through advanced therapies that clean out old, damaged cells and replace them with the vitality of youth. It’s not just science fiction; it’s happening now. If you’ve ever wished you could freeze time or even roll it back, this episode is your roadmap.

FULL show notes: https://www.jjvirgin.com/gladden

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If you've ever experienced unexpected discomfort during the night, you might already suspect that something's off. But did you know that your body could be crying out for more magnesium? This mineral is a powerhouse for so many vital functions in our bodies, yet nearly half of us aren’t getting enough of it. Magnesium is crucial for everything from energy production to overall health, and when your levels are low, it can lead to a cascade of issues—many of which we tend to overlook or blame on aging.

Take muscle cramps, for example. Those painful, unexpected spasms are one of the most common signs of magnesium deficiency. And it doesn’t stop there. Low magnesium levels can also manifest as various symptoms affecting your daily life, from your mood to energy levels, and even more serious health concerns. In fact, studies have shown that boosting your magnesium intake can significantly impact your overall well-being, improving several aspects of health that you might not expect.

So, what can you do? Start by reassessing your magnesium intake. Many food sources are rich in this mineral, and I'll share some of my favorites. But let's be real—most of us need to supplement to get those levels up. I take magnesium every night before bed and keep a topical magnesium product on hand for occasional use. It's all about finding what works for you and staying consistent.

Don't ignore those little signals your body sends you. If anything I've mentioned sounds familiar tune in to learn more. It might be time to rethink your magnesium levels and learn more about this essential mineral's impact on your health.

Full show notes: https://www.jjvirgin.com/bodyneedsmagnesium

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Vital Choice wild-caught seafood: https://vitalchoice.sjv.io/daKYGy

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Study: A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps: https://pubmed.ncbi.nlm.nih.gov/34719399/

Study: Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial: https://pubmed.ncbi.nlm.nih.gov/33864354/l

Study: Effects of Magnesium Supplementation on Muscle Soreness and Performance: https://pubmed.ncbi.nlm.nih.gov/33009349/

Study: Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials: https://pubmed.ncbi.nlm.nih.gov/27402922/

Study: Treating arrhythmias with adjunctive magnesium: identifying future research directions: https://academic.oup.com/ehjcvp/article/3/2/108/2669829?login=false

Study: Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational Study: https://pubmed.ncbi.nlm.nih.gov/24500155/

Study: Magnesium and hearing: https://pubmed.ncbi.nlm.nih.gov/12940704/

Study: Magnesium, inflammation, and obesity in chronic disease: https://pubmed.ncbi.nlm.nih.gov/20536778/

Study: The Role of Magnesium in Sleep Health: a Systematic Review of Available Literature: https://pubmed.ncbi.nlm.nih.gov/35184264/

Study: Dietary magnesium deficiency impairs hippocampus-dependent memories without changes in the spine density and morphology of hippocampal neurons in mice: https://pubmed.ncbi.nlm.nih.gov/30500564/

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"Estrogen isn’t just a 'sex hormone'—it’s the life hormone. It’s the key to keeping your heart, brain, and body healthy and vibrant for decades beyond menopause." – Dr. Felice Gersh

In this eye-opening episode of the Well Beyond 40 podcast, I sit down with Dr. Felice Gersh, a leading expert in integrative medicine and a trailblazer in hormone therapy, to tackle one of the most critical yet overlooked health risks for women—heart disease. While breast cancer often dominates the conversation, heart disease remains the number one killer of women, particularly after menopause. Dr. Gersh sheds light on the powerful role that certain hormones play in protecting our bodies and why it’s essential to rethink how we approach hormone replacement therapy (HRT) as we age.

Our discussion is not just groundbreaking—it's life-changing. We explore which hormone makes the most dramatic impact on our bodies as we age, leading to increased risks of heart disease, stroke, and even cognitive decline. But here's the silver lining: it's never too late to take action. Whether you’re 50, 60, or even 70, Dr. Gersh provides compelling evidence that starting hormone therapy later in life can still offer significant benefits, and what crucial steps you can take to support your hormone receptors.

If you’ve ever wondered whether it’s safe to start HRT years after menopause, or if you’ve been told you’re too old to begin, this episode will give you hope and empower you with the knowledge to take control of your health. And for those who’ve battled breast cancer, Dr. Gersh also addresses the complexities of hormone therapy, discussing when it might be safe and effective, and when alternative approaches are necessary.

Tune in to discover why Dr. Felice Gersh is my go-to expert on hormones and aging, and learn how to take proactive steps to protect your heart, your health, and your future. Don’t miss out—this episode is packed with pearls of wisdom that every woman needs to hear.

FULL show notes: https://www.jjvirgin.com/gersh

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Dr. Felice Gersh on YouTube: https://www.youtube.com/channel/UCrbn9RUdGuc6Wq-FT7V4u3g

Study: Estrogen and cardiovascular disease: https://www.sciencedirect.com/science/article/pii/S003306202400015X

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In this episode, we dive deep into a sneaky culprit that could be sabotaging all your hard work: sugar overload. Even if you're steering clear of obvious sweets, hidden sugars might be sneaking into your diet from unsuspecting sources, leaving you feeling drained, struggling with cravings, and frustrated with stubborn weight that just won’t budge. Could sugar be the reason behind your energy roller coaster and those nagging mood swings? We’re uncovering how this sweet stuff can wreak havoc on your body’s energy balance, and what you can do about it.

You’ll learn about the science behind sugar addiction and its surprising effects on brain chemistry, cravings, and your body’s ability to burn fat. We’re breaking down how excess sugar leads to insulin resistance, making weight loss feel impossible despite your best efforts. Plus, we’ll explore the troubling link between sugar and mood disorders, acne, aging skin, and even your immune system’s ability to fight off colds and infections.

Join me as I share a personal story that really hits home, involving my son and a pound of M&Ms—trust me, it's a lesson every parent needs to hear! Whether you’re dealing with persistent cravings, energy crashes, or just can’t seem to lose that stubborn belly fat, this episode is packed with insights that could change the way you think about sugar. Don’t miss out—tune in to find out how to kick the sugar habit for good and start seeing the results you deserve. 

FULL show notes: https://www.jjvirgin.com/sugaroverload

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Sugar Impact Diet: https://reignitewellness.com/products/sugar-impact-diet-paperback-book

Study: Effects of free access to sugar solutions on the control of energy intake: https://www.tandfonline.com/doi/full/10.1080/87559129.2016.1149863

Study: Evidence for sugar addiction: Behavioral and neurochemical effects of intermittent, excessive sugar intake: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2235907/

Study: Today's obesity epidemic may have been caused by childhood sugar intake decades ago: https://www.sciencedaily.com/releases/2019/09/190923164534.htm

Study: Sugar intake from sweet food and beverages, common mental disorder and depression: prospective findings from the Whitehall II study: https://www.nature.com/articles/s41598-017-05649-7

Study: Association Between Adult Acne and Dietary Behaviors: Findings From the NutriNet-Santé Prospective Cohort Study: https://pubmed.ncbi.nlm.nih.gov/32520303/

Study: Sugar-sweetened beverage consumption is associated with abdominal fat partitioning in healthy adults: https://pubmed.ncbi.nlm.nih.gov/24944282/

Study: Doctors warn that sugar can temporarily weaken your immune system: https://www.cnet.com/health/nutrition/sugar-can-lower-your-immune-system/

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“Aging isn't just about the years that pass—it's about how you spend those years. The secret lies in maintaining your cells’ vitality, and that’s what we’re diving into today.” — Dr. Greg Kelly

In this eye-opening episode, I sit down with Dr. Greg Kelly to explore the fascinating world of senescent cells—those "zombie cells" that linger in our bodies as we age, contributing to the aches, pains, and general decline many of us experience. If you've ever wondered why you start to feel "old" well before you're ready to admit it, this conversation will shed light on the cellular mechanisms behind aging and what you can do to turn back the clock.

Dr. Kelly takes us on a journey through the history and science of cellular senescence, explaining how these cells behave like unwelcome houseguests—sticking around longer than they should and causing all sorts of trouble. But there's good news: senolytics, compounds that help clear out these lingering cells, can play a transformative role in how we age. For women in their 40s and beyond, understanding and addressing senescent cells could be the key to unlocking healthier, more vibrant years ahead.

We also dive into practical steps you can take to rejuvenate your cells, from the role of exercise to the emerging science behind intermittent senolytic dosing. Dr. Kelly even shares exciting insights on how senolytics might not only help with common issues like joint pain but could also have unexpected benefits like rejuvenating your hormonal health.

Whether you're already feeling the weight of aging or just want to stay ahead of the curve, this episode offers actionable strategies to help you maintain your youthful vitality. Don’t miss out on this deep dive into the future of aging and how you can harness it to live better, longer.

FULL show notes: https://www.jjvirgin.com/senolytics Reignite Wellness™ Magnesium Body Calm: https://reignitewellness.com/products/magnesium-body-calm Qualia Senolytic Placebo-Controlled Clinical Study Results: https://qualialife.com/studies/qualia-senolytic-placebo-controlled-clinical-study-results

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In this eye-opening episode of Well Beyond 40, we're pulling back the curtain on seemingly innocent foods that might be sabotaging your health. Prepare to be shocked as we expose the truth behind six everyday dietary staples that have been masquerading as "healthy choices" all along.  We'll dive deep into breakfast favorites that could be derailing your morning, snacks that promise nutrition but deliver hidden dangers, and beverages masquerading as health elixirs while potentially harming your body. You'll also discover popular treats that might be secretly packing on the pounds.  Throughout the episode, you'll learn how these everyday items could affect your wellness goals, metabolism, and overall health. We'll break down the science behind why these foods are problematic and provide you with some tasty alternatives that satisfy your cravings without the sugar crash. If you've been faithfully consuming these items, thinking you're doing right by your health, this episode is a must-listen. Join us as we demystify food labels, decode marketing hype, and empower you to make truly informed choices about what goes on your plate. Tune in to find out which items you might need to ditch from your pantry and what to stock up on instead. 

FULL show notes: https://www.jjvirgin.com/6foodstoavoid

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Study: Sugar-coating Science: How the Food Industry Misleads Consumers on Sugar: https://www.jstor.org/stable/resrep00047?searchText=plain+versus+sweetened+yogurt&searchUri=%2Faction%2FdoBasicSearch%3FQuery%3Dplain%2Bversus%2Bsweetened%2Byogurt%26so%3Drel&ab_segments=0%2Fbasic_search_gsv2_SYC-7149%2Ftest&refreqid=fastly-default%3Aa83d09b37e84401a8921ca7a3577a629&seq=2

Study: Systematic review of the effect of processing of whole-grain oat cereals on glycaemic response: https://pubmed.ncbi.nlm.nih.gov/26330200/

Study: Bad popcorn in big buckets: portion size can influence intake as much as taste: https://pubmed.ncbi.nlm.nih.gov/16053812/

Study: Dried fruit consumption and cardiometabolic health: a randomised crossover trial: https://pubmed.ncbi.nlm.nih.gov/32513313/

Study: Beverages contribute extra calories to meals and daily energy intake in overweight and obese women: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840121/

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"Doing hard things not only makes other hard things easier, but actually has incredible benefits for longevity and resilience." - Jeff Krasno

In this episode, I had the pleasure of chatting with Jeff Krasno, the co-founder and CEO of Commune, a masterclass platform for personal and societal well-being. Jeff's journey is a compelling testament to the transformative power of lifestyle changes, especially for those of us navigating the complexities of life beyond 40.

Jeff's story is deeply personal and relatable. Four years ago, despite being a prominent figure in the wellness industry, he found himself struggling with borderline diabetes and significant weight issues. This wake-up call led him to embrace intermittent fasting, heat and cold therapy, and other wellness protocols. His commitment to these practices resulted in a remarkable transformation—he lost 60 pounds and reclaimed his health and vitality at age 50.

In this episode, you'll discover a surprising ally for women over 40 - the concept of "good stress." Jeff explains how embracing challenges that echo our ancestral past can be a key to unlocking better health. You'll learn why pushing your comfort zone benefits not just your mind, but your body at the cellular level. The conversation explores simple, ancestrally-inspired habits that can transform your overall wellness, and how facing challenges head-on contributes to ageless vitality. Jeff offers valuable insights on how small, consistent changes in your routine can lead to significant improvements in your health journey. This discussion is particularly relevant for women looking to enhance their wellbeing after 40, providing practical strategies for reclaiming vitality and resilience.

Jeff's dedication to his health journey is inspiring, and his practical advice on integrating these protocols into daily life is invaluable. He encourages us to start with small, manageable steps—whether it's getting outside for morning light to set our circadian rhythms or beginning with gentle squats and gradually increasing intensity. His approach is about creating sustainable habits that support overall well-being.

Don't miss this episode if you're looking for actionable strategies to enhance your health and vitality. Jeff's insights are not only informative but also deeply motivating, offering a roadmap for anyone looking to reclaim their health and live a more vibrant life. Tune in to hear more about Jeff's journey and discover the tools and techniques that can help you thrive well beyond 40.

FULL show notes: https://www.jjvirgin.com/onecommune

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Ozempic might be the latest buzzword in weight loss, but it’s not the only option out there. If you're looking to manage cravings and hunger naturally, this episode is for you. I'm revealing nine natural appetite suppressants that are not only effective but also easy to incorporate into your daily routine. Say goodbye to expensive injections and hello to Mother Nature's best-kept secrets for effortless weight management.

You’ll learn what to prioritize in your meals to feel fuller for longer and keep those pesky cravings at bay. I’ll share a free 7-Day Challenge along with some of my favorite foods and practical tips to help you boost your intake of natural appetite suppressants to help you feel full, stabilize your blood sugar, and support your overall gut health without feeling overwhelmed. Trust me, your body will thank you!

And don't underestimate the power of hydration—drinking water before meals can significantly reduce your calorie intake and keep hunger at bay.

FULL show notes: https://www.jjvirgin.com/ozempicalternatives

7-Day Eat Protein First Challenge: http://jjvirgin.com/proteinfirst Track your protein & macros with Cronometer App: jjvirgin.com/cronometer

Try Calocurb: jjvirgin.com/calocurb use code JJVIRGIN10 for 10% off your order

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Get 60 FREE delicious, protein-packed shake recipes in my Eat Protein First Smoothie Guide: https://jjvirgin.com/smoothie

Study: Effect of short- and long-term protein consumption on appetite and appetite-regulating gastrointestinal hormones, a systematic review and meta-analysis of randomized controlled trials: https://pubmed.ncbi.nlm.nih.gov/32768415/

Study: The role of dietary fibers in regulating appetite, an overview of mechanisms and weight consequences: https://pubmed.ncbi.nlm.nih.gov/36193993/

Study: d-Allulose Inhibits Ghrelin-Responsive, Glucose-Sensitive and Neuropeptide Y Neurons in the Arcuate Nucleus and Central Injection Suppresses Appetite-Associated Food Intake in Mice: https://www.mdpi.com/2072-6643/14/15/3117

Study: Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study: https://pubmed.ncbi.nlm.nih.gov/31263284/

Study: New Zealand Bitter Hops Extract Reduces Hunger During a 24 h Water Only Fast: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893682/

Study: An exercise-inducible metabolite that suppresses feeding and obesity: https://www.nature.com/articles/s41586-022-04828-5

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"Your brain is like a muscle—it's use it or lose it. And the best part is, you can start strengthening it at any age." - Jim Kwik

In this captivating episode, I chat with Jim Kwik, a renowned brain performance coach and New York Times bestselling author of "Limitless." Jim's journey from struggling with a traumatic brain injury in childhood to becoming a leading expert in brain health and learning is nothing short of inspiring. He turned his "broken brain" into a catalyst for discovering how to optimize brain function, proving that no matter our age, we can continually learn and grow.

For many women in their 40s and beyond, Jim's story is particularly resonant. It underscores that it's never too late to improve cognitive abilities and debunks the myth that aging inevitably means a decline in mental sharpness.

Tune in to hear Jim walk us through his top 10 keys to unlock brain health. Jim emphasizes that our brains need novelty and nutrition to thrive. He also provides practical advice on which foods boost brain function, and how to integrate them into our diets. His innovative mnemonic techniques make it easy to remember these foods, ensuring that we can all support our brain health effortlessly.

Jim’s insights extend to practical strategies for protecting our brain health through proper sleep, stress management, and positive peer interactions. He also introduces us to his unique brain type assessment, which helps tailor learning strategies to individual strengths. Whether you're a cheetah, owl, dolphin, or elephant, understanding your brain type can revolutionize how you approach learning and personal development.

Join us in this episode to uncover actionable steps to enhance your brain health, optimize learning, and maintain cognitive vitality. Jim Kwik’s transformative advice is perfect for anyone looking to upgrade their brain and unlock their exceptional life at any age.

FULL show notes: https://www.jjvirgin.com/kwik

Learn more about Jim Kwik: https://www.jimkwik.com/

Free Jim Kwik Brain Nutrition Guide: https://brainnutrition.com/free

Reignite:Wellness Clean Creatine Powder: https://reignitewellness.com/products/clean-creatine-powder

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In today's episode, we explore common mistakes that can hinder your intermittent fasting success. Tune in to hear the common pitfalls I see all the time that can sabotage your fat loss and make you gain weight instead. Learn about simple but crucial changes to boost your metabolism and address insulin sensitivity issues. We'll discuss research on meal timing and its impact on your body's natural rhythms, and I'll share insights on optimizing eating schedules for better health outcomes.

One major pitfall we'll address is how you approach your feeding windows. We'll delve into the importance of balanced eating and avoiding extreme behaviors that can sabotage your efforts. Discover strategies for maximizing the benefits of intermittent fasting, including its effects on cellular processes and hormone regulation. I'll also reveal my personal approach to managing hunger and maintaining muscle mass during fasting periods.

Another crucial aspect we cover is the role of nutrition and hydration in your fasting routine. Learn why the quality of your food choices matters and how proper hydration can impact your results. I'll offer practical tips for staying on track and explain why consistency in your fasting schedule is essential for long-term success. Finally, we’ll discuss the importance of micronutrients and how to ensure you meet your body’s needs. 

Join me as we uncover these essential insights and actionable tips to make your intermittent fasting journey successful and sustainable!

FULL show notes: https://www.jjvirgin.com/fastingmistakes

7-Day Eat Protein First Challenge: http://jjvirgin.com/proteinfirst

Reignite Wellness™ Magnesium Body Calm: https://reignitewellness.com/products/magnesium-body-calm

Download my free Resistance Training Cheat Sheet: https://jjvirgin.com/resistance

Sugar Impact Diet: https://reignitewellness.com/products/sugar-impact-diet-paperback-book

Study: Beneficial Effects of Early Time-Restricted Feeding on Metabolic Diseases: Importance of Aligning Food Habits with the Circadian Clock: https://www.mdpi.com/2072-6643/13/5/1405

Study: Health Benefits of Fasting and Caloric Restriction: https://link.springer.com/article/10.1007/s11892-017-0951-7

Study: Synergistic effects of caloric restriction with maintained protein intake on skeletal muscle performance in 21-month-old rats: a mitochondria-mediated pathway: https://pubmed.ncbi.nlm.nih.gov/17142793/

Study: Brain–Gut–Microbiome Interactions and Intermittent Fasting in Obesity: https://ncbi.nlm.nih.gov/pmc/articles/PMC7916460/

Study: 10-Hour Eating Window Boosts Mood and Energy: https://neurosciencenews.com/intermittent-fasting-mood-25207/

Study: Assessment of water consumption during Ramadan intermittent fasting: Result from Indonesian cross-sectional study: https://pubmed.ncbi.nlm.nih.gov/35958263/

Study: Intermittent fasting 5:2 diet: What is the macronutrient and micronutrient intake and composition?: https://pubmed.ncbi.nlm.nih.gov/32199696/

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