A recent analysis of 22 St. John’s Wort supplements purchased online found that only one actually matched its label for the key compound hypericin. Several products contained little to none of the active ingredient, and some appeared to use synthetic dyes to mimic the color of hypericin, potentially misleading simple testing methods (Now, 2025).

Why does this matter? Because when a supplement doesn’t contain the ingredient it claims, patients may not receive the support they expect. That can lead to wasted money, confusing clinical outcomes, and lost trust in integrative care. In this episode of the Root Cause Medicine Podcast, we’re joined by Dr. Eric Viegas, Medical Product Manager at Fullscript, to unpack what this report means for clinicians and patients. We discuss how ingredient discrepancies can happen—from plant sourcing and manufacturing to risks in online marketplaces—and how practitioners can help protect patients from misleading products. We also explore what clinicians should look for when choosing supplements, including validated testing methods, Certificates of Analysis, and quality standards that help ensure products contain what the label promises.