You push through exhaustion, telling yourself it's just stress. Your body sends signals you can't ignore: chronic fatigue, unexplained pain, digestive issues, mood swings. What if these are messages about the emotional wounds that remain unresolved from your past?

In this episode, I sit down with Dr. Partha Nandi for a conversation on chronic health issues, share five key insights that transform how we understand trauma's biological impact. This episode gives you the core concepts from the new book, The Biology of Trauma, about how trauma impacts your body, your own biology maintains the survival state and the repair tools needed for healing.

 

Key Topics & Timestamps:

• [00:50] Why I Wrote This Book: For the high-performing person who doesn't realize their body is accumulating trauma until a health crisis forces recognition
• [01:18] The 2014 Wake-Up Call: From marathon runner to unable to get out of bed during surgery residency - the moment everything changed
• [03:01] Trauma as Biology, Not Psychology: How adverse childhood experiences become measurable disease patterns decades later
• [04:29] The Biology of Being Stuck: Understanding functional freeze and why growth becomes impossible in trauma states
• [06:14] Science-Based Healing Pathways: Creating biology of safety through mitochondrial support, antioxidants, and repair tools
• [08:26] What Makes This Book Different: Bridging Western medicine with trauma healing using specific biomarkers and measurable changes
• [10:30] Beyond Trauma-Informed Awareness: Why awareness without actionable tools still fails patients and what to do instead
• [17:00] Insight #1 - Internal Response Matters: Trauma isn't the event - it's your body's five-step sequence during overwhelm
• [19:01] Insight #2 - The Critical Line: Your invisible boundary between experiences that grow you versus break you
• [21:23] Insight #3 - Cellular Trauma Reality: How mitochondria literally change shape and function during overwhelm
• [23:51] Insight #4 - Essential Sequence: Safety, support, then expansion - why most people skip the crucial first step
• [26:54] Insight #5 - Biology as Healing Ally: How the same systems holding trauma become your greatest recovery resource

 

Main Takeaways:

• Trauma Becomes Biology: Adverse experiences create measurable changes in cellular function, mitochondrial energy production, and nervous system regulation that can manifest decades later

• Cell Danger Response: When overwhelm crosses a critical threshold, mitochondria physically change shape and switch to survival energy systems, creating chronic symptoms

• Universal Trauma Response Pattern: All overwhelming experiences follow the same five-step sequence - startle, stress, powerlessness, freeze, shutdown - regardless of the trigger

• Biological Markers Matter: Heart rate variability, mitochondrial function, and inflammatory markers provide objective evidence of trauma's cellular impact

• Critical Line of Overwhelm: Everyone has an invisible threshold between experiences that grow us versus break us, which shifts daily based on current capacity

• Essential Sequence for Healing: Recovery requires three phases - safety, support, then expansion - with most approaches failing by skipping biological safety first

• Integration is Required: Trauma affects mind, body, and biology simultaneously, requiring coordinated intervention across all levels for lasting change

• Personalized Repair Approach: Effective healing identifies individual biological blocks rather than applying generic protocols to complex trauma presentations

• Cellular Recovery is Possible: The same mitochondria that hold trauma patterns can restore optimal function when given proper conditions and support

 

Notable Quotes

"I wrote it really for the person who I used to be. I used to be the person who, despite all of my education, despite even being a very, I would say, high performing person, I didn't realize how much trauma my body was holding and I didn't realize it until I got very sick."

"Your cells experience trauma too. You can't therapy or supplement your way out when your cells and body systems are stuck in survival mode."

"Your mitochondria literally change shape, becoming round and rigid instead of long and flexible, and they switch to a backup energy system that produces less energy but can function under threat."

"When you cross that critical line of overwhelm, your cells engage their own emergency break called the cell danger response. Just like your nervous system shuts down for protection, your cellular powerhouses, your mitochondria shift from efficient energy production to barely surviving."

"Most people skip the safety phase though and jump straight into deep processing, and this often retraumatizes them."

"Your symptoms are messengers, your reactions are information, and your healing journey becomes a collaboration with the incredible wisdom your body has been holding all along."

"It gives me a language to explain myself, my trauma, and my experience to others." - Early Reader

 

Episode Takeaway

The Biology of Trauma book reveals how adverse experiences rewire cellular function through the cell danger response, causing mitochondria to shift into survival mode and creating chronic health problems years later. Understanding trauma's biological reality at the cellular level provides both validation for mysterious symptoms and specific repair tools. When mitochondria are stuck in survival mode, psychological interventions alone cannot restore optimal cellular function - healing requires addressing biological dysfunction through targeted mitochondrial support, reducing cellular inflammation, and following the essential sequence of safety, support, and expansion at the cellular level. This integrated approach bridges the gap between understanding trauma's impact and having actionable tools to address it, offering hope for those whose symptoms have resisted conventional treatment by targeting the root biological mechanisms where trauma actually lives.

 

Resources Related To This Episode

Resources/Guides:

• The Biology of Trauma book - Available now everywhere books are sold. Get your copy

Related Episodes:

• Episode 122: Shutdown Before Stress: The Misstep in Trauma Healing That Often Gets Missed

• Episode 129: Why You're Still in Survival Mode (Even After Years of Therapy and Healing Work)

Related YouTube videos:

• Why Your Body Is Wired for Danger: Understanding Trauma's Impact on Your Nervous System

• Mitochondria’s Role in Trauma Work with Gabor Maté 

Your host: Dr. Aimie Apigian, double board-certified physician (Preventive/Addiction Medicine) with master's degrees in biochemistry and public health, revolutionizes trauma healing by revealing how our cells—not just our minds—store trauma. Her book "The Biology of Trauma" (foreword by Gabor Maté) transforms our understanding of how the body experiences and holds trauma. After adopting a child during medical school sparked her journey, she developed an integrative science-based sequence for the healing journey. Through her practitioner training, podcast, YouTube channel, and international speaking, she bridges functional medicine, attachment and trauma therapy, proving that repairing trauma's impact on the mind, body and biology is possible.

 

Disclaimer: By listening to this podcast, you agree not to use this podcast as medical, psychological, or mental health advice to treat any medical or psychological condition in yourself or others. This podcast is for informational and educational purposes only and does not constitute professional advice, diagnosis, or treatment. Always consult your own physician, therapist, psychiatrist, or other qualified health provider regarding any physical or mental health issues you may be experiencing.

Comment Etiquette: I would love to hear your thoughts on this episode! Please share your constructive feedback by using personal name or initials so that we can keep this space spam-free, and let's keep the discussion positive!