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By Dr. Aimie Apigian
4.8
215215 ratings
The podcast currently has 242 episodes available.
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Your labs confirmed the autoimmune diagnosis. The hardest symptom turned out to be the one nobody prepared you for. Dr. Aimie goes solo on depression and autoimmunity, and which one actually comes first. The answer is less orderly than the one most people are given, and it changes what to do about it. ➡️ Full show notes and research: CLICK HERE Most people are told depression is a reasonable response to being ill. Dr. Aimie interrupts that conclusion with what the research shows: each condition carries close to double the risk of the other, depression turns up in the two years before a diagnosis is made, and roughly a quarter of the link between early adversity and autoimmune disease appears to travel through mental health on the way. She also walks through why this depression rarely feels like sadness, and why the medication may have underperformed. She was on two of them herself, and the hardest part was not the depression. WHAT YOU'LL LEARN: 0:00 The hardest symptom of an autoimmune diagnosis 02:41 — Why is depression treated as the reasonable response to a diagnosis? 04:49 — What does double the risk actually mean for you? 07:58 — What is a dose-response pattern and why does it matter? 09:45 — Where does the childhood adversity evidence stop? 12:19 — What does it mean that depression mediates part of the link? 13:54 — What happens when your cells stop responding to cortisol? 15:55 — Why does this feel like the flu rather than sadness? 20:48 — Why has working on your thoughts not moved it? 22:55 — Why do antidepressants underperform here? 24:54 — What does the infliximab trial actually prove? 28:48 — Where do you start when both are running? "Depression is part of the road from I was healthy to I now have an autoimmune diagnosis." — Dr. Aimie Apigian If the antidepressant did not do much and you quietly concluded something was wrong with you, this episode is for you. RESOURCES: Take the FREE 2-Minute Assessment for Discovering Your Pattern of Stored Trauma: You cannot change a pattern you cannot see. Find your primary pattern of responding when life becomes too much, then see how the other four show up. Get The Biology of Trauma: Disease is one of the five patterns of stored trauma. Nothing in this episode is a recommendation to change or stop a medication. Talk to the prescriber who knows your history. This episode is educational and is not medical advice. Please work with your own qualified healthcare provider for decisions about your care. Grab your copy of The Biology of Trauma

You have been doing the work. The therapy, the somatic practices, the self-care. And your body still will not come online. You have also been doing the gut protocol. Months of it. And the exhaustion has not lifted. Here is what almost nobody tells you. The thyroid governs gut motility. When it runs low and slow, the bloating and the constipation you have been treating from the gut end may have been downstream of the thyroid the whole time. So you can do everything right, in the right order, and still be working the wrong end of the problem. This is Part 2 with Dr. Amie Hornaman, known as the Thyroid Fixer. She was misdiagnosed six different times in her twenties before anyone found it. In this episode she gets practical about selenium, about which system to start with, and about why she thinks adrenal fatigue is overdiagnosed. She also gives a number for how long before your energy and stress resilience actually shift, with the caveat that belongs beside it. WHAT YOU'LL LEARN: Which to treat first when your gut and thyroid are both struggling How a slow thyroid produces constipation, bloating and SIBO The foundational nutrients she starts everyone on, and why selenium leads Why one morning cortisol reading cannot tell you what you think it does How long before energy, mood and stress resilience begin to move The full show notes have the research behind the SIBO connection, every quote from the episode, the chapter list, and the optimal lab ranges to ask about. Read the full show notes: https://www.biologyoftrauma.com/post/gut-or-thyroid-first-when-you-are-in-chronic-freeze RESOURCES: Get the Stress or Trauma Guide Part 1 of this conversation By listening to this podcast, you agree not to use it as medical, psychological, or mental health advice to treat any condition in yourself or others. This podcast is for informational and educational purposes only. Always consult your own qualified health provider. Grab your copy of The Biology of Trauma

You have been doing the work. You understand your patterns. And you are still waking up unable to face the day. When the body decides survival is the priority, it stops converting thyroid hormone into the form your cells can use. It produces an inactive version instead, called reverse T3, and that version blocks the active hormone at the cell door. The result is a body running low and slow. It is the same physiology I call chronic functional freeze. Dr. Amie Hornaman ranks reverse T3 as the single most important thyroid marker, ahead of free T3, and it is a marker almost nobody orders. She also holds that stress and trauma on their own can raise it. This is Part 1 of a two part conversation. ➡️ Full show notes, research and timestamps: https://www.biologyoftrauma.com/post/can-a-thyroid-problem-keep-me-in-chronic-freeze WHAT YOU'LL LEARN: Why a normal TSH does not settle the question of whether your thyroid is involved What reverse T3 is, and why Dr. Hornaman ranks it above free T3 How stress and trauma can shift thyroid function directly Why the hibernation state and chronic functional freeze are the same physiology What happens to the thyroid in the year after an injury or accident Why you cannot think your way out of a decision the body made below thought RESOURCES: Take the free 2-Minute Assessment for Stored Trauma: https://biologyoftrauma.com/quiz Stress or Trauma Guide The Biology of Trauma: https://www.biologyoftrauma.com/book The Thyroid Fix by Dr. Amie Hornaman Part 2 releases August 20, 2026. Grab your copy of The Biology of Trauma

➡️ Get the full episode breakdown at Biology of Trauma® Podcast – Episode 164: Could Your Trauma Be Disrupting Your Metabolism? The Weight Health Conversation What if the reason your body is holding onto weight has nothing to do with what you're eating — and everything to do with hormones you may not have heard about? In this episode, Dr. Aimie talks with registered dietitian and author Ashley Koff to unpack the hidden world of weight health hormones: GLP-1, leptin, ghrelin, and more — and why optimizing them matters for everybody, not just people trying to lose weight. What you'll hear will change how you see your body — not as something failing you, but as a sophisticated ecosystem sending you signals worth decoding. Ashley reveals why 93% of Americans are metabolically dysregulated, how trauma and chronic stress directly suppress the hormones that regulate metabolism and body composition, and why "weight loss" as a goal is actually working against your biology. Whether you're curious about GLP-1 medications, perimenopause weight changes, or just why the scale never seems to match your effort — this conversation will shift everything. In This Episode You'll Learn: (00:00): Introducing the connection - weight, metabolism and GLP-1 (02:04): The weight-trauma connection: Why the body holds on despite every effort (03:00): What “weight health” means biologically — and why weight loss as a goal misses the point (05:59) The incretin discovery: How GLP-1, leptin, ghrelin, and seven other weight health hormones regulate your biology (09:50).Why 93% of Americans show signs of suboptimal metabolic health — and what that actually means for you (10:33) Ashley’s pizza framework: The right sequence for assessing your metabolic ecosystem (14:54) How to assess your weight health hormones — and why a blood test alone won’t tell you what you need to know (22:56) Perimenopause and menopause: Why digestion fails first — and how that drives belly fat and brain fog (30:14) Learned behaviors vs. hormone imbalance: How to tell what is biology and what is a survival strategy from childhood (37:29) Where to start: Ashley’s first step for anyone wanting to optimize weight health (40:41) The deliciousness signal: Why a “seven or above” is a physiologic mechanism, not a preference (44:05) Ashley’s final message — where to find (her book) Your Best Shot and her clinical resources Resources/Guides: Your Best Shot by Ashley Koff, RD: The Personalized System for Optimal Weight Health — GLP-1 Shot or Not Ashley Koff’s website — For more on digestive, metabolic, and hormone health optimization The Biology of Trauma® Book by Dr. Aimie Apigian — Where you can find the framework for finding your block in Chapter 12 Free Guide: Steps to Identify and Heal Trauma by Dr. Aimie Apigian Related Podcast Episodes: Episode 56 — Hormones: A Portal Into Our Stored Trauma with Dr. Aimie Apigian Episode 75 — Fear Stored in the Gut: Attachment, Relational Trauma & Solutions for the Hyper-Sensitive Gut Episode 82 — Using Biological Rhythms to Recover From Trauma with Dr. Leslie Korn Episode 138 — Why Your Body Holds On When Your Mind Has Healed Episode 151 — Why Healed Trauma Returns in Perimenopause: Chinese Medicine Lens with Dr. Lorne Brown Grab your copy of The Biology of Trauma

Why do so many people suddenly start losing weight when they finally escape a toxic relationship or environment? What if your body's stubborn weight isn't about willpower, metabolism, or even food - but about stored trauma keeping you in survival mode? When you're trapped in toxic relationships or environments, your body operates from what I call chronic functional freeze. This isn't just emotional - it's a complete biological shutdown that affects everything from your thyroid function to your detoxification pathways. Your metabolism hibernates, toxins accumulate, and your body holds onto weight as a survival strategy. In this Biology Behind It mini episode, I answer practitioner Zay's excellent question about why clients lose weight effortlessly after leaving toxic situations, even without doing deep healing work yet. I break down the hidden biology keeping you stuck and why your nervous system won't let go of excess weight until it feels truly safe. You'll hear more on: Why avoiding feelings creates a biology of energy conservation and metabolic shutdown How chronic functional freeze affects your thyroid hormones - including reverse T3 that doctors rarely test The connection between stored trauma and toxin accumulation that makes weight loss impossible Why detoxification pathways shut down when your nervous system is in survival mode How toxic relationships create the same biological effects as physical toxins Why your inner operating state drives all your body systems - not individual organ problems How creating inner safety naturally eliminates coping mechanisms like emotional eating The integrated approach to clearing both emotional and physical toxins safely Whether you've struggled with stubborn weight that won't budge despite your efforts, or you're supporting someone who's finally ready to leave a toxic situation, this episode reveals why your body refuses to let go until your nervous system feels safe. I give you hope that when you address the real root - stored trauma - your body naturally returns to health. 🎧 Want the full story? Listen to Episode 137: "Does Somatic Healing Work: How Mind-Body Healing Can Change 30 Years of Chronic Illness In 6 Weeks" for Keisha's complete transformation story and the science behind rapid healing. Grab your copy of The Biology of Trauma
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