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Episode Outline: Why Retatrutide Isn’t for Everyone

1. Overview

• What retatrutide is and why it’s generating hype
• Quick reminder it’s still investigational

2. Nervous System & Cardiovascular Effects

• Increased resting heart rate
• Lower HRV and sympathetic activation
• Why certain people feel “revved up”

3. Sleep Disruption

• Trouble falling asleep
• Light, fragmented sleep
• “Wired but tired” pattern linked to HRV + stress hormones

4. Increased Hunger on Retatrutide

• Why some experience more hunger vs. tirzepatide
• Inconsistent appetite suppression
• Glucagon receptor activation + stress = stronger hunger signals

5. Difficulty Switching From Tirzepatide

• Rebound hunger during the transition
• Loss of steady appetite control
• Early retatrutide dosing not matching tirzepatide stability

6. Individual Variability

• Stress levels, hormones, genetics, and titration pace all change response

7. Key Takeaway

• Retatrutide is powerful but not universally tolerated
• HRV, hunger, sleep—your body’s feedback matters