What does it really take to lose weight and keep it off for good? Ethan sits down with Dr. Holly Wyatt to unpack the science of metabolism, appetite regulation, and long term weight management. They explore why the body resists weight loss, how biology influences hunger, and what actually works beyond willpower. Dr. Wyatt shares practical insights drawn from decades of clinical research, offering clarity in a space full of confusion.

If you are serious about understanding sustainable fat loss, this conversation delivers real answers.

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SHOW HIGHLIGHTS

00:00:00 Welcome, Dr. Holly Wyatt

00:02:09 Ethan’s Weight Loss History

00:04:32 Appetite and Hormones Explained

00:12:31 The Reality of Weight Loss Maintenance

00:13:57 Extreme Calorie Restriction

00:16:37 Why We Regain Weight

00:18:28 Metabolism Adaptation

00:30:45 Set Point and Biological Defense

00:40:26 Exercise and Long-Term Health

00:50:34 Final Takeaways on Sustainable Fat Loss

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