What does it really take to lose weight and keep it off for good? Ethan sits down with Dr. Holly Wyatt to unpack the science of metabolism, appetite regulation, and long term weight management. They explore why the body resists weight loss, how biology influences hunger, and what actually works beyond willpower. Dr. Wyatt shares practical insights drawn from decades of clinical research, offering clarity in a space full of confusion.

If you are serious about understanding sustainable fat loss, this conversation delivers real answers.

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SHOW HIGHLIGHTS

00:00:00 Welcome, Dr. Holly Wyatt

00:02:09 Ethan’s Weight Loss History

00:04:32 Appetite and Hormones Explained

00:12:31 The Reality of Weight Loss Maintenance

00:13:57 Extreme Calorie Restriction

00:16:37 Why We Regain Weight

00:18:28 Metabolism Adaptation

00:30:45 Set Point and Biological Defense

00:40:26 Exercise and Long-Term Health

00:50:34 Final Takeaways on Sustainable Fat Loss

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Is your favorite superfood actually a marketing success story? Ethan sits down with Natalie Alibrandi, a nutrition and food science expert who helps take products from concept to commercialization, to unpack how food trends are born. They explore the rise of kale, goji berries, cottage cheese hacks, and the powerful role marketing plays in shaping what we believe is healthy.

Natalie breaks down formulation, regulation, and the realities of the food industry, while Ethan digs into how consumer psychology drives demand.

00:00 Introduction and Natalie’s Background

05:42 How Food Trends Are Born

12:18 The Rise of Superfoods

18:47 Marketing vs Nutritional Reality

26:15 Product Formulation and Food Science

34:02 Consumer Psychology and Health Claims

42:30 The Business of Health Foods

50:11 Regulation, Labels, and Transparency

58:27 Social Media and Trend Acceleration

01:05:44 Final Thoughts and Takeaways

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How do you navigate the mental and physical hurdles of long term weight maintenance? In this episode of American Glutton, Ethan Suplee sits down with host Paige to answer listener questions on everything from breaking through stubborn plateaus to the realities of life after GLP 1 medications.

Ethan shares his personal strategies for managing intense food cravings with healthy hacks and explains why he prioritizes sleep as the essential foundation for any successful health journey. He also offers advice on using a diet break to reset your metabolism when progress stalls.

• Swapping to Egg Whites
• Calculating Caloric Maintenance
• The Work of Weight Maintenance
• GLP 1s and Regaining Weight
• Navigating Cravings and Food Hacks
• Prioritizing Sleep Over the Gym
• Using Diet Breaks to Reset

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What happens when you come face to face with death and are forced to make a choice?

Ethan sits down with Jaimie Alexander to unpack a raw, deeply personal story about sobriety, self-worth, and survival. Jaimie opens up about being a highly functioning alcoholic, the quiet rationalizations that kept her drinking, and the medical crisis that nearly took her life. What followed was a moment of clarity that changed everything and led to a commitment she could not ignore. This conversation is honest, emotional, and unfiltered, exploring pain, meaning, and the power of choosing to stay.

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SHOW HIGHLIGHTS

00:00 Wired Headphones and Small Talk

00:26 Jaimie’s Journey to Sobriety

01:31 High-Functioning Alcoholism Explained

03:13 The Illusion of Control

05:54 Drinking as Medication

06:07 The Question of Rock Bottom

09:03 Dating, Anxiety, and Drinking Before the Date

10:38 Accidentally Sober in a Snowstorm

15:10 Withdrawal, Denial, and Pushing Through

18:03 Severe Appendicitis and Ignored Pain

21:44 Facing Death in the Operating Room

25:54 “Do You Want to Stay or Go?”

29:43 Surviving Against the Odds

31:18 Choosing to Stay Alive

36:26 Power, Perspective, and Agency

41:30 Self-Kindness as a Practice

47:24 Meaning, Suffering, and Choice

53:57 Toxic Positivity vs Real Empathy

58:04 Sobriety, Growth, and Closing Reflections

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What if improving your physical health was never the real starting point?

In this episode, Ethan sits down with Dr. Tara Narula, cardiologist, journalist, and author, to explore the often ignored mental and emotional foundations of health. Together, they unpack the science of stress, the reality of mind body connection, and why resilience is not about toughness but about acceptance, flexibility, and daily practice.

Dr. Narula shares deeply personal stories from her medical training and clinical work, revealing how trauma, mindset, and social connection directly impact heart health and longevity. This conversation challenges quick fixes and offers a more honest blueprint for lasting change.

Want more thoughtful conversations like this?

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What if weight gain, depression, and chronic illness are symptoms rather than the real problem?

Ethan sits down with Dr.Josh Redd, a functional medicine doctor, to explore why treating symptoms alone often fails. On this episode of American Glutton, Ethan Suplee and Dr. Redd dig into inflammation, metabolic dysfunction, mental health, and why personalized care matters more than one-size-fits-all diets or pills. They discuss real patient stories, overlooked root causes, and what true healing can look like.

Want more insights like this? Subscribe to Ethan’s newsletter here: https://ethansuplee.substack.com/subscribe

SHOW HIGHLIGHTS

00:00 - What Functional Medicine Really Means

04:10 - Treating Root Causes Instead of Symptoms

09:05 - Why One Size Fits All Diets Fail

14:40 - When Weight Is a Symptom, Not the Problem

20:30 - Brain Inflammation and Mental Health

27:15 - The Emotional Cost of Chronic Illness

32:40 - A Child’s Drawing That Changed Everything

38:20 - Why Patients Feel “Crazy” When Labs Are “Normal”

45:10 - Food, Inflammation, and Modern Lifestyles

52:35 - Why Healing Requires Education, Not Just Treatment

59:40 - What Real Health Transformation Looks Like

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What does it really mean to start over without punishing yourself? Ethan Suplee sits down with Paige Dorian to unpack the emotional and psychological weight of restarting, whether it is after the holidays, a setback, or yet another failed plan. Ethan speaks candidly about crash diets, the illusion of quick fixes, and why weight loss is something to manage, not cure.

Together, they explore sustainable habits, realistic readiness, and the importance of support and accountability. This conversation is a grounded reminder that real change comes from compassion, not extremes.

SHOW HIGHLIGHTS

00:00 Starting Over and January Resets

02:05 The Gloom of Restarting

06:38 Why Crash Diets Fail

09:31 Sustainable Change vs Quick Fixes

12:17 Mindless Eating and Awareness

14:57 Exercise and Unrealistic Expectations

19:36 The Readiness Formula

24:03 Weight Loss vs Life Improvement

26:01 Accountability and Support Systems

30:55 Managing Weight for Life

36:44 Broadening the Goal Beyond Weight

42:19 Compassion, Guardrails, and Self Control

48:00 New Year Perspective

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"What diet should I do?" It is one of the most common questions Ethan receives. In this solo episode, Ethan sits down to address the complexities of starting a weight loss journey. He shares his personal history with extreme diets, explaining how reducing responsibility with food initially helped him gain control.

Ethan discusses the psychological benefits of diet breaks, the reality of loose skin, and the dangers of scale obsession. He emphasizes that whether you choose keto, veganism, or calorie reduction, the key is finding a sustainable long term plan.

For more insights, sign up for Ethan's newsletter here: https://ethansuplee.substack.com/subscribe

SHOW HIGHLIGHTS

0:00 The "What Diet Should I Do?" Question

1:17 Extreme Diets and Initial Goals

2:43 Reducing Responsibility with Liquid Diets

4:47 The Trap of Yo-Yo Dieting

5:50 Reintroducing Carbs and Food Intolerance

7:37 Diet Plateaus and Metabolic Adaptation

9:45 The Importance of Maintenance Periods

11:28 Maintenance is Still a Diet

13:17 Handing Power Over to Someone Else

14:38 Finding the Right Approach for You

15:45 Using Extreme Diets as a Mental Reset

17:34 The Reality of Loose Skin

18:48 Overcoming Scale Obsession

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What really drives sustainable weight loss, and why do so many popular diets fail people long term?

Ethan sits down with Tony Bloom to unpack the confusion, frustration, and misinformation surrounding modern diet culture. Drawing from personal experience and years in the fitness industry, Tony explains why no single diet is magic, how social media amplifies bad nutrition advice, and why communication and individualization matter more than dogma.

Ethan reflects on his own history with keto, calorie fear, and chasing the “right” answer, revealing how mindset and adherence shape real results. This episode cuts through noise and ideology to focus on what actually works for humans in the real world.

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SHOW HIGHLIGHTS

• Meeting Tony Bloom
• Escaping Diet Fads
• Ethan’s Keto Experience
• Why Diets Become Dogma
• Individualization Matters
• The Map Is Not Reality
• When Simple Answers Fail
• Wanting to Hear the “Right” Answer
• Changing Your Mind Is Hard
• Weight Loss vs Health Debates
• Language and Definitions
• What a Calorie Really Is
• Why Calories Trigger People
• The Mental Game of the Scale
• Preference vs Truth
• The White Coat Problem
• Trust, Credentials, and Reality
• Adherence Over Ideology
• Final Takeaways

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Is it ever too late to rewrite your habits and reclaim your health? In this episode, Ethan sits down with returning guest Lisa De Pasquale to discuss her latest book, *The Gen X Handbook to Middle Age*. Together, they dive deep into the unique experience of their generation, exploring how "latchkey kids" are now navigating the challenges of aging and health.

Ethan and Lisa bond over their shared history, discussing how the explosion of processed food in the 1980s shaped their early habits and left them to figure out wellness later in life. Lisa opens up about her own transformation, detailing her 170-pound weight loss and the reality of maintaining it while dealing with loose skin and the physical limitations that come with getting older. They discuss the importance of making fitness fun, using movie montage playlists to stay motivated, and why perfection is not the goal.

The conversation touches on the nostalgia of fast food culture, the judgment surrounding diet choices, and why it is crucial to reject the idea that you have missed the boat on getting healthy.

For more insights and updates on health, wellness, and Ethan’s personal journey,

be sure to sign up for his newsletter here: https://ethansuplee.substack.com/subscribe

SHOW HIGHLIGHTS

00:00 Intro and Welcome

00:39 The Gen X Identity Crisis

02:07 The Wealth Transfer Myth

03:22 The First Generation of Processed Food

05:37 Starting Health Journeys Later in Life

07:19 The Power of the Perfect Workout Playlist

10:31 Training Montages and Movie Nostalgia

13:17 Adapting Workouts to Busy Schedules

15:17 The Realities of Aging and Mobility

17:51 Fast Food Nostalgia and Marketing Collabs

20:25 The Judgment of Food Choices

25:18 How Independence Fueled Bad Habits

29:51 There Is No Finish Line

32:05 Dealing with Loose Skin and Surgery

37:06 Swimwear Anxiety and Body Image

38:29 Generational Food Pyramids

41:18 The Politics of Health and Food

44:23 Dealing with Public Disappointment After Weight Loss

47:43 Navigating Career Identity Post-Weight Loss

49:03 The Gen X Approach to Plastic Surgery

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