Dr. Orville Kolterman explains how the gut microbiome, probiotics, and GLP-1 pathways support blood sugar balance and type 2 diabetes management.

Dr. Orville Kolterman dives into the critical role of the gut microbiome in blood sugar regulation and type 2 diabetes. He explains how butyrate-producing bacteria and Akkermansia protect gut integrity, regulate GLP-1, and reduce cravings while improving insulin sensitivity. He also highlights Pendulum’s probiotic formulations, which combine science-backed strains with prebiotic fibers to restore balance, support metabolic health, and empower people with type 2 diabetes to achieve better glucose control.

Dr. Orville Kolterman is an endocrinologist with decades of experience in diabetes research, drug development, and clinical care. A former faculty member at the University of California, San Diego, he helped pioneer peptide-based therapies, including the first GLP-1 analog for metabolic disease. After transitioning from biotech, he joined Pendulum as Chief Medical Officer, where he has spent the last ten years advancing microbiome-based solutions for type 2 diabetes. His work continues to bridge science and practice, empowering people to manage blood sugar better through innovative approaches.