October 23, 2025

#232 NAD+, Energy & Longevity: How to Restore Cellular Power Naturally | Dr. Dan Pardi @Qualia

1 hour 26 minutes

Ever wonder why your energy fades faster as you age?

Dr. Dan Pardi of Qualia Life Sciences explains how NAD+ supports metabolism, DNA repair, & brain health, & how simple bioharmonizing habits can restore your cellular power naturally.

Meet our guest

Dr. Dan Pardi is the Chief Health Officer at Qualia Life Sciences, where he designs health-improvement journeys, guided protocols & education systems that simplify complex science for lasting results.

Formerly the founder & CEO of humanOS.me & Chief Health Architect at Restore Hyper Wellness, he’s led collaborations with top researchers, military units & wellness organizations.

With a PhD in Cognitive Neuroscience & a background in Exercise Physiology, Dr. Pardi empowers people & institutions to master healthspan, performance & resilience through science-backed systems.

Thank you to our partners

Outliyr Biohacker’s Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear

Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more

Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world

FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus

Key takeaways

NAD existed before life & kickstarted living processes

NAD+ is a universal coenzyme that transfers energy across all cells, keeping you alive & well

Enzymes act like machines while coenzymes (NAD+) serve as the tools they need to work

NAD+ sits at the center of all metabolic processes, regulating glucose, building, & breaking down substances

Mainstream interest in NAD+ surged after Dr. David Sinclair’s book Lifespan hit shelves around 2017

NAD+ levels drop every decade, leading to less energy & slower cellular repair with age

Sun exposure both helps & harms Too much damages DNA & drains NAD+ through increased repair demands

Chronic inflammation & DNA damage reduce NAD+ levels faster, causing energy loss & fatigue

Oral NAD+ precursors boost cellular energy more efficiently than IV NAD+ for daily health with fewer side effects

Good sleep, regular exercise, & healthy habits maintain NAD+ levels, slowing aging & improving performance

Episode highlights

0:00 Why NAD+ is the spark of life

01:44 How NAD+ fuels energy & longevity

11:15 Why NAD+ declines & how to preserve it

25:22 Choosing the right NAD+ strategy

48:31 Lifestyle habits that protect NAD+

51:31 Signs your NAD+ is running low

Links

Watch it on YouTube: https://youtu.be/QKtf71Othu0

Full episode show notes: outliyr.com/232

Connect with Nick on social media

Instagram

Twitter (X)

YouTube

Easy ways to support

Leave an Apple Podcast review

Suggest a guest

Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!

Be an Outliyr,

Nick

...more

View all episodes

By Nick Urban | Longevity, Biohacking, & Performance

1717 ratings