Ever feel tired & anxious even when your labs look “normal”?

Dr. Scott Sher explains how mitochondrial dysfunction & metabolomics reveal what’s really happening at the cellular level & why optimizing your mitochondria changes energy, focus, & resilience.

Dr. Scott Sherr is an integrative hyperbaric medicine specialist and co-founder of Troscriptions, the company behind the first commercial pharmaceutical-grade methylene blue product. He provides worldwide hyperbaric consultation, education, and advocacy. With nearly 6 years of clinical experience using methylene blue troches, he has developed protocols bridging mitochondrial dysfunction and nervous system recalibration. Dr. Sherr also co-founded Health Optimization Medicine and Practice (HOMe/HOPe), a nonprofit training clinicians in a 7-module framework for cellular health optimization. He is the founder of OneBase Health, developing next-generation sensor and app technology for health monitoring.

01:01 Holobiont concept: Why Dr. Sherr reframes biohacking as “biont hacking”

06:01 Sympathetic spiral of doom: How chronic fight-or-flight drains mitochondria

14:04 HRV as a nervous system barometer

21:25 Mitochondria beyond the textbook

41:00 Five root causes of mitochondrial dysfunction

48:50 Methylene blue as a mitochondrial bridge

50:58 GABA-glutamate imbalance in brain signaling

53:26 Obligatory pairs for GABA support

01:07:37 The parasympathetic edge for performance & recovery

Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!

Be an Outliyr,

Nick

Ever wake up tired even when you slept enough?

Brett Aldrich shares how Ayurveda and circadian-aligned living, like morning sunlight, seasonal eating, & simple self-massage… restore steady energy, digestion, & long-term resilience

Brett Aldrich is an Ayurvedic Counselor, Breathwork Practitioner & founder of Seed the Spirit in Portland, Maine, blending decades of service with holistic training. Her work spans supporting trauma survivors & children with developmental needs to guiding clients through Ayurveda, breathwork & yoga. A graduate of the Kripalu School of Ayurveda & affiliated with the Global Professional Breathwork Alliance, she helps people cultivate lasting physical, emotional & spiritual balance through simple, sustainable practices.

0:00 Introduction

03:41: Anchor your day with ayurvedic daily rhythms

11:03: Strengthen digestion as the foundation of health

18:31: Personalize practices to your constitution

32:13: Align with circadian & seasonal cycles

37:00: Adapt ayurveda for modern high performers

59:11: Cultivate self-compassion for sustainable change

Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!

Be an Outliyr,

Nick

What if the secret to longevity isn’t more data, but better direction?

Julian breaks down how personalized biomarkers, mindset, & meaningful relationships shape long-term performance far more than chasing every new biohacking trend.

Julian Issa is the host of The Beyond Tomorrow Podcast, exploring longevity, mindset & human potential while helping people navigate change with clarity & agency. An exited tech founder, investor & former Newsweek journalist who conducted over 1,500 interviews worldwide, his perspective spans media, business & global leadership. Today, he is a sought-after moderator & speaker at major longevity events, driven by a mission of human flourishing for all.

01:23 Build longevity on community, purpose & bioharmony

02:45 Master fundamentals before chasing advanced therapies

07:55 Personalize every domain of health

08:35 Use data wisely without outsourcing self-awareness

15:14 Transform suffering into agency & growth

44:14 Redefine performance, success & experimentation

Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!

Be an Outliyr,

Nick

That mattress you’ve had for 8 years?

It might be aging you.

Derek Hales from Nap Lab shares what 500+ mattress tests reveal about support, toxins, cooling, & durability & how the wrong materials quietly wreck sleep, joints, & long-term health.

NapLab began when founder Derek & his wife Samantha searched for an affordable mattress in 2014 & started reviewing their experiences online. What began as a hobby site called Sleepopolis quickly grew into a full testing operation, expanding from a one-bedroom apartment into a dedicated review facility. Derek & his team have now tested over 500 mattresses, helping millions make smarter purchasing decisions.

0:00 Introduction

03:30 Make smarter mattress buying decisions

08:10 Use objective testing to separate hype from performance

12:32 Choose healthier materials & avoid hidden risks

14:03 Match firmness & build to your body

18:27 Extend mattress lifespan with proper care

32:15 Keep sleep simple & focus on consistency

Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!

Be an Outliyr,

Nick

Could nature-based principles outperform modern productivity hacks?

This episode, Dr. Aldrich Chan connects neuroscience, Daoist wisdom, & bioharmonized living to help high achievers move out of survival mode & into a more grounded, adaptive, & high-performing state.

Dr. Chan is a neuropsychologist, psychotherapist & award-winning author of Reassembling Models of Reality & 7 Principles of Nature: How We Strayed & How We Return. He is the founder of the Center for Neuropsychology & Consciousness in Miami, with a background in research on Alzheimer’s disease, trauma & the Default Mode Network, plus experience teaching at Pepperdine University. His work integrates neuroscience, psychotherapy, mindfulness, creativity & long-standing study of Daoism & Zen.

01:17 Identify why modern life creates suffering

05:39 Use nature-based principles to restore function

09:57 Apply creativity & process for adaptive performance

36:14 Strengthen relationship & wholeness

54:27 Maintain equilibrium without rigidity

01:01:06 Activate spontaneity & transformation

Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!

Be an Outliyr,

Nick

Ever wonder how repeated hits affect the brain long after the game ends?

William Person shares his firsthand experience with CTE, sub-concussive impacts, & cognitive decline, revealing why high-impact sports carry hidden risks for mental health & long-term performance.

William Person is a former nine-year Team USA bobsled athlete whose career left him battling severe CTE symptoms including cognitive decline, depression & debilitating headaches. After discovering Hyperbaric Oxygen Therapy, he regained mental clarity, vision & purpose, inspiring a new mission focused on brain healing. Today, William is raising awareness around brain injury in sports, the military & beyond while working to open a nonprofit Post Concussion Recovery Center to provide care at no cost.

0:00 Expose Hidden Brain Injury Risks in Elite Sports

6:12 Connect CTE to Mental Health Decline

15:48 Challenge Medical & Organizational Failures

25:36 Understand How CTE Develops Over Time

36:58 Explore Recovery Pathways & Treatment Hope

51:42 Build Advocacy Community & Next Steps

Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!

Be an Outliyr,

Nick

Think recovery tools only work if you use everything at once?

Jake Ross breaks down how combining PEMF, far infrared, red light, & natural gemstones creates consistent gains in energy, nervous system balance, and performance, without complicated routines.

Jake Ross is part of the leadership and growth marketing team at HealthyLine, where he helps translate advanced recovery technologies into real-world routines for athletes and health-focused individuals. He focuses on product education, customer experience, and how PEMF, infrared, red light, and gemstone therapies support recovery and longevity.

00:00 EMFs as an invisible performance stressor in modern environments

04:28 PEMF explained and how controlled frequencies support recovery

10:58 Why recovery habits drive longevity and performance

22:17 Building sustainable recovery routines that actually stick

38:50 Stacking PEMF, infrared, red light, and natural elements

52:42 Long-term recovery mindset and avoiding quick-fix thinking

Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!

Be an Outliyr,

Nick

Ever wonder which health trends are actually worth your time in 2026? Nick Urban breaks down what truly moves the needle… active wearables, multi-sensor monitoring, recovery systems, & environment-first strategies that deliver measurable ROI.

Nick Urban is a BioHarmonizer, athlete, and founder of Outliyr.com, as well as the host of theHigh Performance Longevity podcast. A certified Chek Practitioner, Personal Trainer, and Performance Health Coach, he bridges the gap between ancient medical systems like Ayurveda & Traditional Chinese Medicine and cutting-edge modern science.

Nick is dedicated to distilling the wisdom of the world’s top performers into practical strategies, helping others transition from merely surviving to truly thriving.

0:00 Introduction

01:23Track health trends with systems thinking

02:29 Move from passive wearables to active regulation

05:39 Optimize foundational inputs like water & air

09:17 Personalize health with multi sensor intelligence

12:32 Train mental fitness & nervous system resilience

21:02 Redefine recovery longevity & future health

Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!

Be an Outliyr,

Nick

Could reaction speed be the missing metric for brain health?

Dexter Ang shares how wrist-based neurotechnology quantifies cognition, personalizes interventions, & supports long-term mental performance for executives & elite performers.

Dexter Ang is the co-founder & CEO of Pison Technology, developing wearable neuromuscular sensing & nervous system interfaces. Inspired by caring for his mother after her ALS diagnosis, he returned to MIT to build sensors that translate wrist biopotentials into digital commands. His work bridges human biology & digital systems across assistive technology, robotics, IoT & defense.

00:00 Measure Brain Performance with Real World Signals

01:20 Turn Personal Adversity into Cognitive Innovation

03:05 Use Reaction Time as a Core Brain Health Biomarker

07:54Train Cognition Through Feedback not Guesswork

14:02 Apply Cognitive Data to Performance & Resilience

33:58 Integrate Neural Data into Personalized Experimentation

Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!

Be an Outliyr,

Nick

What makes methylene blue so different from most nootropics is how little it takes to have an effect.

In this clip, Mark Sloan explains why ultra-low doses of methylene blue can support mental clarity, calm energy, and mitochondrial performance without overstimulation.

You’ll hear why:

Tune in to Episode 68, where we go deeper into methylene blue, mitochondria, metabolic health, and why low-dose strategies often outperform aggressive protocols.

Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!

Be an Outliyr,

Nick