High Performance Longevity

RNA microbiome testing reveals what DNA gut tests fundamentally miss. Your gut bacteria have 3,000+ genes each — DNA tests see zero of their actual activity. Dr. Momchilo (Momo) Vuyisich, Co-founder & CSO of Viome and former Los Alamos National Laboratory scientist, explains why RNA-based metatranscriptomics is a quantum leap over DNA sequencing for understanding your microbiome and personalizing nutrition.

Dr. Momo Vuyisich spent 12 years at Los Alamos National Laboratory developing RNA-based technology for digitizing human biology. He co-founded Viome in 2016 with Naveen Jain, and the platform has since tested 500,000+ customers across 100+ countries. His personal journey with NEU5GC autoimmune sensitivity drove his mission to replace opinion-based nutrition with data-driven, personalized recommendations.

00:00 Introduction

02:44 Why RNA is the single best molecule to study

06:16 RNA instability — why it took 6 years to develop

08:02 Why 16S sequencing is nearly useless

11:02 Akkermansia's 3,000 genes: help or harm?

17:37 Microbiome as a dynamic self-adjusting ecosystem

23:20 NEU5GC sensitivity & mammalian food reactions

25:50 Food sensitivities (IgG) vs allergies (IgE)

29:55 Viome's 3-part approach: seal gut, reduce inflammation, personalize

41:07 Biological aging clock: keto & paleo age faster

49:13 Dry fasting crashed mitochondrial function score

52:07 Machine learning identifies metabolic bottlenecks

1:00:23 Viome measures 25% of human biology, 10% actionable

Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!

Be an Outliyr,

Nick

Are you busy all day but never finishing the work that actually matters? What if the problem isn't discipline — it's that you've never learned how to enter a flow state on demand?

Steven Puri joins Nick Urban to break down the science and practice of flow states. Steven shares the exact protocol he built after two decades in Hollywood and tech: how music at 60-90 BPM triggers focus, why rain sounds outperformed $100K of custom compositions, and the morning intention habit he calls the single highest-ROI practice for productivity.

Steven Puri is the Founder and CEO of The Sukha Company, a flow state productivity platform helping knowledge workers find their focus and do their best work. Before building Sukha, Steven served as VP at 20th Century Fox running the Die Hard and Wolverine franchises, EVP at DreamWorks Pictures for Kurtzman-Orci Productions (Star Trek, Transformers), and produced CGI for 14 films including Independence Day. He sold his first tech company, Centropolis Effects, at age 28. Steven lives in Austin, TX.

00:54 Steven's background: Hollywood, startups & flow state discovery

02:58 What is a flow state? Csikszentmihalyi's research explained

11:05 How "Sukha" got its name on a honeymoon in Bali

18:35 Music for flow: the 60-90 BPM sweet spot

22:32 Why rain sounds crushed $100K of custom music

29:54 Social media is engineered to steal your focus

35:27 The #1 morning habit for peak productivity

37:13 Default mode network: why great ideas come when you're not trying

42:17 Physical space = mental space (the $5 million villa story)

47:32 Time blocking & Pomodoro customization

52:05 How a dad finished his PhD in 60-minute flow sessions

Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!

Be an Outliyr,

Nick

You don't have a motivation problem. You have a TRUST problem. And the fix is so embarrassingly simple, you'll laugh at it — but it works. Acusio Bivona lost his relationship, his business, his friends, and nearly his mind... all in 5 months.

What he built from the wreckage? A 90-day protocol that's helping founders go from total system failure to operating at a level they didn't know existed

Acusio Bivona is a Human Performance Architect and founder of The Resurrection Protocol. After 10 years as a personal trainer in Los Angeles, he experienced 5 catastrophic life events in 5 months and used the rebuilding process to design a coaching methodology for high-achieving men. His approach fuses spiritual philosophy with physiological interventions to reverse burnout and restore command-level energy.

03:05 Reframing adversity as divine intervention

06:22 Kaizen philosophy: action breeds clarity

08:52 Unbreakable Promises explained

12:03 Hot Fusion vs Cold Resonance

15:02 Why fitness is the non-negotiable first pillar

20:21 Anterior midcingulate cortex: the "do hard muscle"

25:45 Attachment theory: anxious to earned security

28:53 What system failure actually looks like

32:56 You are your own primary care doctor

34:02 Solitude, silence, and meditation twice daily

37:37 Flow state and detaching from outcomes

43:34 Protocol Zero: first 48 hours after crisis

44:47 Digital blackout: 7 days off social media

47:07 Freedom app for enforcing the blackout

Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!

Be an Outliyr,

Nick

Ever wonder why you spend hundreds on antioxidant supplements but still feel run down?

What if the most powerful antioxidant isn't in your supplement cabinet — but already inside your body?

François Vix, CEO of GliSODin with 40+ published clinical studies across 50+ countries, reveals why superoxide dismutase (SOD) neutralizes up to 1 billion free radicals per molecule while vitamin C handles just one. He breaks down the oxygen paradox driving "inflammaging," how mad cow disease nearly erased SOD from modern medicine, and the gliadin coating breakthrough that finally made oral supplementation possible..

François Vix is the President & CEO of GliSODin and a 20+ year leader in health innovation. He held strategic roles at L'Oréal, Lancôme, Biotherm, and Neutrogena International before founding Laboratoires Isocell in 2001 after identifying a stable, bioavailable form of superoxide dismutase. Today, GliSODin is available in 50+ countries with 40+ clinical studies and over 300 million daily doses sold worldwide.

One molecule of SOD neutralizes up to 1 billion free radicals, while one vitamin C molecule neutralizes just one

SOD hasn't changed in 2.5 billion years of evolution — it was dubbed "the enzyme of life" when discovered in 1968

Primary antioxidants (SOD, catalase, glutathione) work 24/7 while secondary antioxidants like vitamins are quickly spent 

Mad cow disease killed injectable SOD in the '90s, and the scientific community assumed oral SOD was impossible 

GliSODin's patented gliadin coating protects SOD through stomach acid and sticks to the small intestine wall for optimal absorption

Just 2 weeks of SOD pre-treatment protected white blood cell DNA from fragmentation during 3-bar hyperbaric oxygen exposure

SOD doesn't just boost the immune system — it regulates it, downregulating hyperactive responses in autoimmune conditions like vitiligo

SOD production naturally declines after age 40, making supplementation more relevant for midlife and beyond

01:18 What is superoxide dismutase and why it's called the enzyme of life 

06:29 The oxygen paradox and how inflammaging accelerates aging

07:59 SOD vs vitamin C — the 1 billion to 1 ratio explained

11:53 Why synthetic vitamins fall short of enzymatic antioxidants

15:41 Mineral cofactors your body needs to produce SOD

18:23 Does supplementing SOD downregulate your natural production?

25:20 SOD and hyperbaric oxygen — the DNA protection study

31:03 How mad cow disease nearly erased SOD from medicine                                                    

34:00 The gliadin coating breakthrough for oral delivery                                                                 

42:15 Is GliSODin safe for people with gluten sensitivity?                                                                

46:27 Lifestyle factors that deplete your SOD levels                                                                      

51:53 How SOD regulates autoimmune conditions like vitiligo

Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!

Be an Outliyr,

Nick

Ever feel exhausted no matter what you try, or notice new symptoms you can't explain since 2020?

Dr. Evan Hirsch reveals the Toxic Five framework, the hidden combination of heavy metals, chemicals, molds, infections, & nervous system dysfunction that are the real root causes of chronic fatigue, long COVID, & autoimmunity.

 Dr. Evan Hirsch is a board-certified MD and the founder of EnergyMD, where he specializes in treating chronic fatigue syndrome and long COVID. He has spent over a decade helping thousands of patients identify and address the root causes of their low energy. Dr. Hirsch resolved his own chronic fatigue syndrome using the same Toxic Five framework he now teaches. His 4-step process uses 100% natural tinctures and supplements, increased one drop at a time, to systematically detoxify at a rate each individual can tolerate. He operates online as a health coach and hosts the EnergyMD Podcast.

About 36% of everyone who has had COVID develops persistent symptoms, making it a trillion-dollar annual problem most people don't even realize they have

The Toxic Five (heavy metals, chemicals, molds, infections, nervous system dysfunction) cause 80% of the deficiencies that functional medicine typically treats as primary problem

Over 90% of chronic fatigue cases can be identified through patient history & symptoms alone, saving thousands in unnecessary lab work Illness operates on 3 levels: lifestyle fixes, replacing deficiencies (adrenals, mitochondria, thyroid), & full Toxic Five removal for stubborn cases

Biofilms shelter infections & toxins in a toxic matrix. COVID disrupts these biofilms, releasing dormant infections like Bartonella & Babesia

A free 4-step mindset practice (gratitude, vision, belief flipping, empowering questions) combined with vagal toning rewires the nervous system

Peptides, stem cells, ozone, & other advanced biohacks work best after 6-12 months of Toxic Five treatment, not before

00:55 Why most people have long COVID and don't even know it

03:10 The Toxic Five that are secretly draining your energy

04:19 How your pet could be making you sick & the symptoms to watch for

07:47 The 3 levels of illness and what to do at each one

13:59 The one-drop method that prevents detox disasters

30:01 A free daily practice that rewires your nervous system

34:06 Why peptides, stem cells, and biohacks keep failing you

Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!

Be an Outliyr,

Nick

Ever feel tired & anxious even when your labs look “normal”?

Dr. Scott Sher explains how mitochondrial dysfunction & metabolomics reveal what’s really happening at the cellular level & why optimizing your mitochondria changes energy, focus, & resilience.

Dr. Scott Sherr is an integrative hyperbaric medicine specialist and co-founder of Troscriptions, the company behind the first commercial pharmaceutical-grade methylene blue product. He provides worldwide hyperbaric consultation, education, and advocacy. With nearly 6 years of clinical experience using methylene blue troches, he has developed protocols bridging mitochondrial dysfunction and nervous system recalibration. Dr. Sherr also co-founded Health Optimization Medicine and Practice (HOMe/HOPe), a nonprofit training clinicians in a 7-module framework for cellular health optimization. He is the founder of OneBase Health, developing next-generation sensor and app technology for health monitoring.

01:01 Holobiont concept: Why Dr. Sherr reframes biohacking as “biont hacking”

06:01 Sympathetic spiral of doom: How chronic fight-or-flight drains mitochondria

14:04 HRV as a nervous system barometer

21:25 Mitochondria beyond the textbook

41:00 Five root causes of mitochondrial dysfunction

48:50 Methylene blue as a mitochondrial bridge

50:58 GABA-glutamate imbalance in brain signaling

53:26 Obligatory pairs for GABA support

01:07:37 The parasympathetic edge for performance & recovery

Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!

Be an Outliyr,

Nick

Ever wake up tired even when you slept enough?

Brett Aldrich shares how Ayurveda and circadian-aligned living, like morning sunlight, seasonal eating, & simple self-massage… restore steady energy, digestion, & long-term resilience

Brett Aldrich is an Ayurvedic Counselor, Breathwork Practitioner & founder of Seed the Spirit in Portland, Maine, blending decades of service with holistic training. Her work spans supporting trauma survivors & children with developmental needs to guiding clients through Ayurveda, breathwork & yoga. A graduate of the Kripalu School of Ayurveda & affiliated with the Global Professional Breathwork Alliance, she helps people cultivate lasting physical, emotional & spiritual balance through simple, sustainable practices.

0:00 Introduction

03:41: Anchor your day with ayurvedic daily rhythms

11:03: Strengthen digestion as the foundation of health

18:31: Personalize practices to your constitution

32:13: Align with circadian & seasonal cycles

37:00: Adapt ayurveda for modern high performers

59:11: Cultivate self-compassion for sustainable change

Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!

Be an Outliyr,

Nick

What if the secret to longevity isn’t more data, but better direction?

Julian breaks down how personalized biomarkers, mindset, & meaningful relationships shape long-term performance far more than chasing every new biohacking trend.

Julian Issa is the host of The Beyond Tomorrow Podcast, exploring longevity, mindset & human potential while helping people navigate change with clarity & agency. An exited tech founder, investor & former Newsweek journalist who conducted over 1,500 interviews worldwide, his perspective spans media, business & global leadership. Today, he is a sought-after moderator & speaker at major longevity events, driven by a mission of human flourishing for all.

01:23 Build longevity on community, purpose & bioharmony

02:45 Master fundamentals before chasing advanced therapies

07:55 Personalize every domain of health

08:35 Use data wisely without outsourcing self-awareness

15:14 Transform suffering into agency & growth

44:14 Redefine performance, success & experimentation

Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!

Be an Outliyr,

Nick

That mattress you’ve had for 8 years?

It might be aging you.

Derek Hales from Nap Lab shares what 500+ mattress tests reveal about support, toxins, cooling, & durability & how the wrong materials quietly wreck sleep, joints, & long-term health.

NapLab began when founder Derek & his wife Samantha searched for an affordable mattress in 2014 & started reviewing their experiences online. What began as a hobby site called Sleepopolis quickly grew into a full testing operation, expanding from a one-bedroom apartment into a dedicated review facility. Derek & his team have now tested over 500 mattresses, helping millions make smarter purchasing decisions.

0:00 Introduction

03:30 Make smarter mattress buying decisions

08:10 Use objective testing to separate hype from performance

12:32 Choose healthier materials & avoid hidden risks

14:03 Match firmness & build to your body

18:27 Extend mattress lifespan with proper care

32:15 Keep sleep simple & focus on consistency

Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!

Be an Outliyr,

Nick

Could nature-based principles outperform modern productivity hacks?

This episode, Dr. Aldrich Chan connects neuroscience, Daoist wisdom, & bioharmonized living to help high achievers move out of survival mode & into a more grounded, adaptive, & high-performing state.

Dr. Chan is a neuropsychologist, psychotherapist & award-winning author of Reassembling Models of Reality & 7 Principles of Nature: How We Strayed & How We Return. He is the founder of the Center for Neuropsychology & Consciousness in Miami, with a background in research on Alzheimer’s disease, trauma & the Default Mode Network, plus experience teaching at Pepperdine University. His work integrates neuroscience, psychotherapy, mindfulness, creativity & long-standing study of Daoism & Zen.

01:17 Identify why modern life creates suffering

05:39 Use nature-based principles to restore function

09:57 Apply creativity & process for adaptive performance

36:14 Strengthen relationship & wholeness

54:27 Maintain equilibrium without rigidity

01:01:06 Activate spontaneity & transformation

Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!

Be an Outliyr,

Nick