The Metabolism, Muscles, and Mindset Podcast

264: The Hunger Genes - MC4R, ANKK1, Satiety, and Fasting


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The FIT Collective Genetic Insights Series – Episode 2


Unlock the Secrets of Your Hunger Genetics and Eating Habits


In this fascinating episode, Dr. Ali Novitsky, Obesity Medicine Expert and Fitness Guru, explores the powerful role genetics play in shaping our appetite, eating behaviors, and how we experience fullness (satiety). Drawing from science and personal experience, she breaks down how certain genes influence appetite, body composition, and emotional eating — and how understanding your genetic blueprint can empower you to make personalized, sustainable health choices.


👩‍👧 Personal Touches & Real-Life Insights

Dr. Novitsky opens with a heartwarming update about her daughter’s upcoming birthday and their summer beach plans, before diving into how her own childhood eating patterns reflect her genetic makeup.


🧬 The Genetic Blueprint of Eating


  • The role of somatotypes (ectomorph, mesomorph, endomorph) in body composition and tendencies toward weight gain or leanness

  • Understanding the genetically predetermined “set point” for weight

  • Personal examples comparing her own adolescent stats with her daughter’s



🧠 Satiety and the MC4R Gene


  • Deep dive into the MC4R gene, a key regulator of satiety

  • How MC4R variants can affect appetite control and lead to overeating

  • A personal story from Olive Garden highlights how genetic predispositions show up in real life


🧪 Emotional Eating & the ANKK1 Gene


  • Introduction to the ANKK1 gene, which affects dopamine response and can drive emotional eating

  • The compounding effects of having multiple genetic variants (like MC4R + ANKK1)


🍽️ Practical Strategies to Support Satiety


  • Protein-first approach when dining out

  • High-protein snacks in the evening to prevent overeating

  • Focus on fiber and hydration to improve satiety

  • Smart use of supplements: omega-3s, vitamin D, fiber, and magnesium

  • Tips for volume eating and managing cravings based on texture


⏰ Fasting and Your Genes


  • How some individuals are genetically wired to skip breakfast

  • Dr. Novitsky shares her personal take on fasting and why it works for her


Your genetics can play a major role in how you feel hunger, how your body responds to food, and your susceptibility to emotional eating. The more you understand your unique genetic makeup, the more effectively you can design a lifestyle that supports your optimal health — without frustration or blame.


Dr. Novitsky is now enrolling participants in her Genetics Program – a unique opportunity to:

✅ Get a genetics testing kit

✅ Receive tailored supplement recommendations

✅ Build a comprehensive health plan based on your DNA


🔗 Enroll now at https://www.thefitcollective.com/genetics-series


🕒 Timestamps:

00:00 – Personal Updates & Intro

03:22 – MC4R Gene & Satiety

10:07 – Satiety Strategies

18:08 – Eating Out Tips

22:00 – Supplements That Help

27:01 – Fasting & Genetics

30:13 – Wrapping Up + Program Info


🎧 Tune in to uncover how your genes might be guiding your hunger, food choices, and even your success in creating lasting healthy habits.


🎯 Ready to Personalize Your Health?


Work with Dr. Ali

• Beginner Strength Training Program – 12 months for only $199! ⁠⁠⁠⁠⁠⁠⁠Enroll TODAY⁠⁠⁠⁠⁠⁠⁠

• Total Fitness Program – A 12-month mind-body experience. ⁠⁠⁠⁠⁠⁠⁠Enroll HERE⁠⁠⁠⁠⁠⁠⁠

• The Fit Collective® x InBody USA/Canada – Get 15% off select models. ⁠⁠⁠⁠⁠⁠⁠Click HERE⁠

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The Metabolism, Muscles, and Mindset PodcastBy Ali Novitsky, MD

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