The Obesity Guide with Matthea Rentea MD

After the Honeymoon Phase: 3 Strategies for Long-Term GLP-1 Success


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The excitement of those first 6–12 months has faded. The scale isn't moving like before, your body feels different, and suddenly year two of GLP-1 treatment doesn't feel straightforward anymore.

This is where many people hit a wall. Progress slows, plateaus arrive, and it's easy to worry you're failing. After months of rapid changes, the slower pace feels frustrating… even defeating. Add in metabolic adaptations and the pressure of maintaining new habits, and year two can feel like uncharted territory.

But this isn't the end of your progress. In fact, it's where sustainable success begins. In this episode, we'll explore what to expect in year two and beyond, including:

  • Three key mindset shifts to help you thrive past year one
  • Why plateaus don't mean your medication stopped working (and what to do instead)
  • How to use non-scale victories to stay motivated when the numbers won't budge
  • Smart strategies to adapt your nutrition, movement, and habits as your body changes

If you've been wondering "what now?" after year one, this episode will give you the framework to tackle year two with confidence!

References

Ep 139: Why "Stopped Working" Is the Wrong Way to Think About GLP-1 Plateaus

Get Your FREE 3-Day Hunger Hormone Reset Mini Video Series

Join the January round of The 30/30 Program

Audio Stamps

00:30 - Introduction to what to expect in year two and beyond on GLP-1s, including the three essential shifts for long-term success.

01:45 - Shift #1: Moving from rapid to steady progress and learning to celebrate non-scale victories when the numbers slow down.

05:34 - Shift #2: Understanding metabolic adaptations and the ongoing adjustments needed for dose, movement, protein, and sleep.

09:24 - Shift #3: Moving into maintenance mode and building the "I do it anyway" identity where healthy habits happen no matter what.

10:50 - Recap of the three key mindset shifts needed for sustainable long-term success on GLP-1.

11:25 - Why maintenance is an active process that requires ongoing adjustments, just like maintaining a hotel or home over time.

13:55 - January 30/30 enrollment is now open with capped group size for optimal support.

All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.

If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.com

Not Sure Where to Start With the Podcast? I’ve Got You.

Get my free Podcast Roadmap—a simple guide to help you find the episodes that matter most to your journey. Whether you're on GLP-1s, navigating plateaus, or just starting out, there's something here for you.


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The Obesity Guide with Matthea Rentea MDBy Matthea Rentea MD

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