DDT Method Podcast — Peptides, Performance Enhancement and Advanced Protocols with Drew Donaldson

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Ten of the most repeated safety beliefs about TRT and steroids don't hold up, and internal medicine physician Dr. Christopher Bronson explains why. Some of these myths make TRT look riskier than it is. Others make steroid use look safer than it is. Drew and Dr. Bronson go through hematocrit and blood donation, blood pressure, ApoB and cholesterol, statins, echocardiograms and calcium scores, and why the rules for a medical TRT patient and a steroid user aren't the same.

If you're on TRT, you might be donating blood you don't need to and draining your iron in the process. If you use steroids, a normal morning blood pressure reading and a zero calcium score can tell you you're fine when you aren't. The tests that look reassuring are often the ones that miss the problem, and the two things that actually lower your risk are cheap and easy to get. So if your bloodwork looks good, your calcium score is zero and your blood pressure is normal every morning, are you actually safe?

Dr. Christopher Bronson is an internal medicine physician whose telehealth practice focuses on testosterone therapy, including many patients with obesity and diabetes. He founded TRTFacts.com and is writing a book on testosterone therapy.

5 Key Takeaways

1. High hematocrit doesn't thicken your blood. What it actually does changes how much you should worry.
2. Why over-donating may raise the very clot risk you were donating to prevent.
3. Why daytime blood pressure isn’t the whole picture for enhanced athletes.
4. Why controlling blood pressure, ApoB and hematocrit alone doesn't make steroids safe.
5. How a zero calcium score can be the most dangerous result a steroid user gets.

Chapters

00:00 The Biggest Mistake Starting TRT 05:40 Who Is Dr. Bronson 11:11 Is High Hematocrit Actually Dangerous? 20:30 Why Hematocrit Stays High 28:15 How Tightly to Control Hematocrit 35:59 Blood Pressure: Morning Readings vs the 24-Hour Test 44:51 Blood Pressure and ApoB Targets for Enhanced Users 51:56 The Heart Damage You Can't Medicate Away 59:06 Why Calcium Scores Mislead Steroid Users 1:04:37 Cholesterol Targets on Medical TRT 1:07:47 Final Thoughts

Connect with Dr. Christopher Bronson

Website: https://trtfacts.com
Instagram: https://instagram.com/cbronsmd
TikTok: https://tiktok.com/@cbronsonmd
YouTube: https://youtube.com/@cbronsonMD
All links: https://linktr.ee/cbronsonmd

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A month and a half ago my heart started skipping beats, and after an EKG, an ER visit, and a cardiologist, the answer was stress, not PEDs.

Nothing was wrong with my heart.

Everything was wrong with how I was running my life.

So this is the first solo episode of the DDT Method Podcast, and it's the whole plan that came out of it. The training, nutrition and… all the compounds I’m taking and what I’m leaving behind.

About me: I'm Drew Donaldson, founder of DDT Method. I spent fifteen years as a pro wrestler including time in WWE developmental, I ran MI40 Gym as head trainer and general manager under Ben Pakulski, and have been using peptides since 2010. I coach, I run the DDT Method School Group, and I'm in a lifelong argument with absolutist fitness advice.

5 Key Takeaways

• The three things that were wrong when my heart started skipping beats, and none of them was my heart.
• Why a calcium score of zero at 38 didn't let me off the hook, and the test that finds what it can't.
• The two blood markers most guys on gear have never heard of, and the one that should keep you off steroids entirely if it's high.
• The announcement: my testosterone dose for the rest of my life, and why I'm done with everything above it.
• How to use fat loss tools by the day instead of by the cycle: which days get BAM15, which get ATX-304, and why they never overlap.

Chapters

0:05 First solo episode: what this is
2:22 A thousand right ways, a million wrong ways
4:41 Comic books, WWE developmental, 250 pounds, and MI40
9:08 Why I learn the mechanism: ATP, ROS, AMPK, mTOR
15:29 The goal: the biggest 200 pounds humanly possible
18:30 The heart scare: skipped beats, stress, a gallon of sweat a day
24:16 Thick blood, and the EKG with the leads on backwards
27:30 Calcium score zero at 38, and why that's not enough
31:05 ApoB and Lp(a): the numbers guys on gear don't know
35:29 Soft plaque, the contrast scan, the echo, and the Holter
38:40 Phase one: macros, water, four hypertrophy sessions
42:14 Steps, four cardio sessions, weighted vests, two HIIT sessions
46:33 Norwegian 4x4s and the four functional sessions
51:00 Hematocrit management and daily injections
53:14 The announcement: replacement dose for life, nothing anabolic on top
56:40 Taurine, TUDCA, senolytics, and the mitochondrial stack
1:03:30 Tirzepatide over retatrutide
1:04:11 SS-31: an Iron Man suit for the cell
1:09:00 Plasmalogens, omegas, carbon 60, glutathione, BPC and TB-500
1:13:01 Bioregulators: Thyrogen, Chelohart, Livagen, Vesugen
1:14:30 The problem with 23-year-old educators
1:18:30 Tesamorelin and the start of the fat loss phase
1:20:40 MBD1 and the futile creatine cycle
1:24:21 BAM15, DNP, and ATX-304: tools by the day, not by the cycle
1:30:58 Epitalon, and FLGR-242 as the January finisher
1:34:30 The tech: multi-wave oscillator, PEMF, CO2, red light, face plunge
1:39:53 You can do cool shit without the hardcore levers
1:42:20 Coaching, consult calls, and the School Group

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If it hurts, stop doing it. That's Joe DeFranco's advice for every man over 40 who's still training like he's 25, and he says he could end the podcast right there. We're glad he didn't, because the next hour is the system behind the most famous rebuild in strength and conditioning: Triple H at 40, body breaking down, one injury after another, willing to trade his physique for function. Joe told him he'd look the same or better. Three months without a heavy back lift, face pulls and band pull-aparts instead of 150-pound dumbbell rows, and his tailor measured his upper back bigger. Sixteen years later they still train together. On this episode of the DDT Method Podcast Drew gets the whole method: no mandatory exercises, upper/lower over the bro split, unilateral lower body, and relative-strength goals like a weighted push-up 10RM that you can't improve while carrying extra body fat.

5 Key Takeaways

• The one piece of advice Joe says could end the podcast, and why most men over 40 ignore it every time they lift.
• Why Joe would make every online coach train people in person for five years first, and the one-in-fifty problem research can't solve.
• The exact changes that rebuilt Triple H, including the three months his tailor noticed before he did.
• The bodyweight above which every one of Joe's health markers goes bad, and the mindset shift that got him under it at 51.
• The weekly template for being good at everything: how many lifts, how many steps, how much zone 2, and the only HIIT session you need.

Chapters

0:00 Where men over 40 are dropping the ball
0:47 If it hurts, stop: listen to your body, not the internet
4:03 From a 500-square-foot storage closet to the New York Giants
9:44 Train people in person for five years before you coach online
18:38 Joe's transformation at 40: satisfied not full, 7.5/10 workouts, move more
23:18 What goes wrong in your 40s even when you do everything right
26:16 Bigger is not better after 40: leaner and stronger
30:18 Good at everything: the pro wrestler problem
33:48 No mandatory exercises: concurrent programming and relative-strength goals
43:32 How Joe rebuilt Triple H: three months without a heavy weight
53:07 The upper/lower split, two-minute mobility, and the unused home gym
1:00:35 Cardio: don't start with Norwegian 4x4
1:04:48 The weekly template: lifts, steps, zone 2, and one HIIT session
1:07:01 Where to find Joe

Connect with Joe DeFranco

Instagram – https://www.instagram.com/defrancosgym/

Website – https://www.defrancostraining.com

YouTube – https://www.youtube.com/joedefranco

Podcast – The Industrial Strength Show

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You have peptide fatigue. We love PEDs, peptides, and small molecules as much as anyone, and we've watched the space go from hunting for Masteron to every person with a phone taking 87 things for every condition they think they have. So on this episode of the DDT Method Podcast Drew brings in Braydon Barrett, a strength coach of 13 years who studied pharmacodynamics and biochemistry on top of exercise physiology, and asks him which peptides are the real needle movers. Braydon answers with a question: what's your biological bottleneck? Because for most people it isn't a peptide. It's the mitochondria, and the things that build mitochondria are the things you're skipping. Two hard cardio sessions a week on top of heavy lifting. Heat. Sleep, which he calls the biggest mitochondrial uncoupler we have, and it's free. MOTS-c and 5-Amino-1MQ sit at the very bottom of his list. Peptides are the essential amino acids. Training is the steak.

5 Key Takeaways

• The one question Braydon asks before he'll name a single peptide, and why most people's honest answer isn't a peptide at all.
• His ranked list for building mitochondria, from the thing no supplement can touch down to where MOTS-c and 5-Amino-1MQ actually land.
• The engine analogy that finally separates biogenesis, mitophagy, and efficiency, and which one you need right now.
• The four-block training system behind Look Like You Lift, and the one macro that moves with every block.
• The number Braydon checks before your body weight in a fat loss phase, and what he does the morning it drops.

Chapters

0:00 Peptide fatigue: when everyone with a phone can buy anything
1:21 Why peptides are the future of medicine, and the counterfeit problem
4:31 A 13-year overnight success: strongman, powerlifting, Look Like You Lift
9:33 Rigidity in training creates rigidity in thinking
13:07 Start with the biological bottleneck, not the peptide
17:08 The best-case peptide candidate: lean, optimized, and still wants more
17:50 Mitochondria are not just the powerhouse of the cell
19:25 What actually builds mitochondria (and where MOTS-c lands)
23:56 Peptides are the amino acids, training is the steak
24:51 The V8 engine: more cylinders, cleaner fuel, better firing
30:29 Reactive oxygen species: redlining the electron transport chain
34:13 The Look Like You Lift system: four training blocks
40:45 Why dedicated blocks beat doing everything at once
42:16 Carbs are the lever that moves with each block
48:06 Your body is a thermostat, not a calculator
51:20 Waking body temp: the number that gives you permission to push
57:29 Cardio: two hard sessions a week, zone 2, and the HIIT you're not doing
1:05:36 Where to find Braydon

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You're collecting peptides like Pokémon. That's Dr. Gabriel Alizaidy's diagnosis in the first ninety seconds of this episode of the DDT Method Podcast, and the next hour is the cure: pick the right tool for the right job, run one or two things at a time, dose low and slow, and let someone who isn't you make the call. Drew's intake forms went from three entries to forty-seven. Both of them have been guilty. Nobody gets to feel superior here.

The section people will replay is mitochondria. SS-31 is physical therapy for your mitochondria. MOTS-c is exercise. Run them in the wrong order and you get the pattern Gabe sees constantly: two great injections, then tired all the time. He explains mitochondria the way he'd explain them to his mom (miles per gallon, exhaust, scrap the broken car), why diet, sleep, and training come before anything goes in a syringe, why MOTS-c works better with exercise instead of replacing it, and the MOTS-c doses he won't touch. Then the wide-angle stuff: red light therapy and nitric oxide, oxytocin as the peptide he uses before public speaking, myostatin inhibitors and FLGR from a safe distance, how Drew finds new compounds before they hit Instagram, why phase 3 trials for BPC-157 and TB-500 aren't coming, and the decision-fatigue conversation that lands where wealthy people already live: get an advisor for this part of your life. First peptide or fifteenth, this is the episode about how to choose.

About the guest: Dr. Gabriel Alizaidy (MD; MS in Precision Health, University of Chicago) came up through CAR-T cancer research at UChicago, runs clinical R&D for a performance-medicine telehealth company, and sat on the FDA's Pharmacy Compounding Advisory Committee that voted this summer to move BPC-157, TB-500, KPV, and MOTS-c toward compounding pharmacies.

5 Key Takeaways

• The one-line diagnosis an FDA panel doctor gives for how most people use peptides.
• Why SS-31 is physical therapy and MOTS-c is exercise for your mitochondria.
• The number of compounds Drew is actually running right now, even though he has vials of everything.
• Why phase three trials for BPC-157 and TB-500 aren't coming, and what a clinical researcher says should stand in for them.
• The reason Gabe says even a knowledgeable person shouldn't build their own stack, and the kind of advisor he thinks belongs in your corner.

Chapters

0:00 Welcome, and how to work with DDT Method
1:24 The #1 peptide mistake: collecting like Pokémon
3:13 Who Gabe is: CAR-T research, telehealth R&D, and the FDA peptide panel
8:17 The new fat-loss compounds, and why he won't rush them
12:53 Mitochondria explained: miles per gallon and exhaust
16:59 The non-negotiables before you inject anything
20:24 SS-31 is physical therapy, MOTS-c is exercise: which comes first
22:58 A word from Amplify Wellness and Janus Optimize
25:33 Low and slow: the doses he won't touch
28:30 Folate, AMPK, and cardiolipin: what the two peptides actually do
33:04 Red light therapy and nitric oxide
38:08 Oxytocin: the peptide for public speaking and connection
42:52 Myostatin inhibitors and FLGR: watching, not touching
47:55 A word from Amplify Wellness, Janus Optimize, and the Skool group
50:09 How Drew finds new compounds, and why RCTs aren't coming
55:56 Less is more: Drew's medicine cabinet confession
1:00:32 Decision fatigue: put the call in an expert's hands
1:06:42 Where to find Gabe

Connect with Dr. Gabriel Alizaidy

Instagram – @gabrielalizaidy

LinkedIn – https://www.linkedin.com/in/galizaidy/

YouTube – https://www.youtube.com/channel/UCiOE4LyFDVoSuQLSLX7SM8A

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Jake Benson is back on the DDT Method Podcast for round three, and it opens on a question a lot of you have sent in: why does kratom (or THC, or the third energy drink) stop working, and why is it so hard to stop?

Jake breaks down what's actually going on under the hood: dopamine as a value scale that tags what's worth remembering, why a substance you rely on is really "paying the withdrawal cost" for you, the kappa-opioid and dynorphin drag that makes the benefit slide under the cost, and why two people on the exact same dose need completely different protocols.

5 Key Takeaways

• Why a substance you rely on is "paying the withdrawal cost" for you, and the signal Drew uses to know when kratom has stopped being worth it.
• The first question Jake asks anyone who wants to quit THC, and why skipping it is the reason most attempts fail in the first uncomfortable week.
• Why the supplement that changed your life will give someone else diarrhea, and what that says about every generic dopamine protocol.
• The six different reasons people procrastinate, and why "low dopamine" is almost never the right label for any of them.
• The single cost Jake removes from a stimulant-dependent entrepreneur's day, and how his own schedule does it without cutting the caffeine first.

Chapters

0:00 Cold open: the substance pays the withdrawal cost
1:59 Drew's kratom case study: why it stops working
9:29 THC, "not addictive," and why there's no THC protocol
14:13 How to actually quit: intent, gatekeepers, and the replacement routine
18:54 No magic supplement: the magnesium story, 9-MeBC, bromantane
22:07 Transcendence: the app Jake is building
24:48 A word from Amplify Wellness, Janus Optimize, and DDT coaching
26:25 Dopamine, undressed: what it actually does
31:23 The dopamine tax: news, social media, and why you were supposed to be bored
35:58 Decide what's yours to care about, and the Brick
39:18 Weaponizing dopamine: intent, procrastination, quiet moments
44:39 The six causes of procrastination
49:33 The entrepreneur avatar: stimulants, the transition tax, and Jake's 2:30 AM schedule
58:20 A word from Amplify Wellness, Janus Optimize, and the Skool group
1:01:42 Euphoria: the four layers of a pre-workout
1:13:04 Wrap-up and where to find Jake

Connect with Jake Benson

Instagram – https://www.instagram.com/jakeyb_43/

Better Through Biology – https://www.betterthroughbiology.com

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Need reliable, third-party tested research compounds: Janus Optimize Code DDTSkool

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Big Pharma just came for retatrutide. Eli Lilly filed six lawsuits against research peptide sellers, a med spa chain, and a compounding pharmacy, compounders got cut off from tirzepatide and semaglutide, and a biologics classification is coming that would make Lilly the only place to get reta. Jay Campbell is back on the DDT Method Podcast to break down who Lilly is targeting and why, what a biologic classification does to generics and compounders, why renaming your GLP-3 isn't a workaround, how Lilly let the research market do its marketing for free for three years, and why the play now is four- and five-pathway agonists and oral delivery, starting with BioLean 4XR, the oral strip BioLongevity Labs is building to replace what Lilly took off the table.

5 Key Takeaways

• The one question Jay asked a stranger who had lost 60 pounds on retatrutide

• What a year of DEXAs and full-body scans on FLGR-242 users showed about the organ-growth
• Why Eli Lilly waited three years to act on retatrutide, and what a biologic classification means for RUO
• Jay’s six-day experiment on SLU-PP-915 vs high-dose SLU-PP-332
• The line between sharing your protocol and making a claim for influencers

Chapters

0:00 Foundation before enhancement: Jay's new book and the 54-year-old on reta
9:47 FLGR-242 one year in: what it is, what it fixed, and what users are seeing
18:35 Non-responders, why DEXA misleads, and how to dose FLGR-242
24:29 How albumin binding made FLGR-242 possible, and Drew's upcoming log
33:08 Bio-IGF: the once-a-week IGF product coming next
38:00 Clotho for the already-optimized: senses, sexual performance, and the kidney trial
44:54 Grounding, sunlight, melanotan, and Drew's foundation reset
50:31 Big Pharma just killed retatrutide: Eli Lilly, biologic classification, and BioLean 4XR
58:59 The six lawsuits, 14,000 websites, and compounders cut off
1:06:22 The influencer legal line: what you can and can't say
1:11:46 SLU-PP-915 vs high-dose SLU-PP-332: the verdict
1:18:23 ATX at high dose, high-dose SS31, and the BioRecharge stack
1:24:28 MOTS-c protocols and phasing AMPK against mTOR
1:29:16 The future of delivery: patches, sprays, and the black market risk
1:36:00 Living Leaner, Longer, Stronger and where to find Jay

Connect with Jay Campbell

Website: https://jaycampbell.com

Living Leaner, Longer, Stronger on Amazon: https://www.amazon.com/dp/B0HDJ41BWS

Fully Optimized Health (private membership): https://jaycampbell.com/foh/

Instagram: https://www.instagram.com/jaycampbell1971/ (

X: https://x.com/JayCampbell333

Substack: https://substack.com/@jaycampbell333

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Chris Gross stepped on stage at the Tampa Pro the leanest he's been since 2018 and the best he's ever looked, and he did it eating 6,000 to 7,000-calorie refeeds up to twice a week. In this episode of the DDT Method Podcast, Drew sits down with Chris and his coach Mike Nassif to break down the contest prep that made it work: why your peak offseason intake should be your refeed day from week one, how high days keep T4 to T3 conversion and free T3 from tanking in a calorie deficit, and why the frequency of those days should go up, not down, as you get leaner. If you've ever stalled in a fat loss phase and blamed metabolic adaptation, this is the mechanism explained by people who manage it for a living.

This isn't just for bodybuilders. Anyone chasing extreme fat loss, whether that's a contest prep, a photoshoot, or just getting truly shredded, will get a repeatable framework here: how to structure refeed days when cutting, why hunger is the signal your diet is working, when a coach introduces a GLP in prep and why not at the start, how to manage fatigue without seven days of cardio, and what the blood work looked like three weeks out and one week post-show. The back half covers the health side of enhancement: the diagnostics Mike requires for his athletes, how to get an echocardiogram and calcium score without a fight, and the blood pressure protocol Drew wishes every client followed.

5 Key Takeaways

1. The refeed rule a pro coach uses to keep the metabolism from downregulating in prep.
2. What "metabolic downregulation" actually looks like on a blood panel.
3. Why zero stress mattered as much as the diet, and what Mike tells athletes who can't just switch it off.
4. When to bring a GLP into a prep
5. The diagnostics Mike requires for enhanced athletes.

Chapters

00:00 Contest prep from a different angle

02:41 The order: 6 to 7,000 calories after six high-carb meals

05:27 Why it didn't break thermodynamics

06:22 Mike's high-day rule: your offseason intake is your refeed

09:22 What metabolic downregulation actually means

10:56 T4 to T3, free T3, and allostatic load

12:52 Zero stress: the other half of the result

14:18 How Chris actually de-stressed

16:30 Coaching athletes who can't just "have fun"

18:25 What changed this prep vs. every prep before

19:54 Stair stepper over treadmill, and the 8-to-5-weeks-out protocol

22:51 Managing fatigue and the timeline Chris kept breaking

26:14 Coach-client communication as a performance variable

28:14 Drew's guardrail: this only works between two professionals

33:37 Peptides in contest prep: what Mike actually uses and when

37:05 Dosing, recovery, and a sponsorship handshake

38:42 Drew's 20-day experiment and inflammatory markers

40:10 Why Chris's hunger came back at higher doses

42:18 Why Mike keeps hunger present on a GLP

44:28 Post-show: back to baseline weight before the reverse

45:29 The blood work: best of Chris's career, three weeks out and one week after

48:48 The peak cycle, on the record

49:36 Clearance time, health supplementation, and doing the little things

53:12 Drew gives Chris his flowers: continued education

55:08 Bioregulators: Chris's two-compound self-experiment

57:47 Calcium scores, echocardiograms, and where to get them cheap

59:52 Mike's required diagnostics for enhanced athletes

01:02:24 Blood pressure: how, how often, and which cuff

01:05:05 Tracking BP with a wearable

01:06:18 Educate yourself, monitor your health

01:08:04 Where to find Chris and Mike

Connect with the Guests

Chris Gross

Instagram: https://www.instagram.com/chrisjohn___/

NeoGen Labs

Mike Nassif

Instagram: https://www.instagram.com/mike_nassif/

Email: [email protected]

Comprehensive bloodwork panels, no doctor visit required: https://ddtmtd.co/Amplify

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Description

Half the WWE roster is in the best shape of their lives and the internet has one question: what are they doing? Jay Ferruggia is the common denominator. He coaches CM Punk, Rey Mysterio, Chad Gable and a who's who of WWE, MLB, NFL and UFC athletes, wrote the Men's Fitness Hardgainer column for a decade, and has spent 30 years fixing the same problems on himself that his clients bring him.

His answer is the opposite of what most lifters are doing. Less volume, harder sets, shorter warm-ups, wider rep brackets, and a logbook that is loosely held. More carbs, less fat, more meals, no fasting. Morning sun, sleep, a walk after dinner. And a scoreboard most people have never checked: their morning body temperature.

Drew and Jay walk through the CM Punk transformation in detail, the recovery tools that actually move the needle versus the ones that just look good on Instagram, why "eat less, move more" is backwards for the people who are already stuck, how Jay programs cardio for busy people in five to ten minutes, and how to balance looking the part with moving like an athlete.

5 Takeaways

• CM Punk was training at 5 reps in reserve with far too much volume. Jay cut the volume and the physique showed up in 6 weeks.
• Jay ate 200 grams of fat a day for years without knowing it. He cut it to 50 and got the leanest he's ever been at 52.
• A 95.6° morning temperature means you don't burn fat, build muscle or fight off a cold. The fix starts with orange juice before coffee.
• Take your temperature before and after a brutal workout. It drops. That's why most of his clients get leaner training less and eating more.
• His warm-up before the 80-pound dumbbells is three sets totaling 12 reps. Most guys do 40 and wonder why the work sets feel heavy.

Chapters

0:00 Intro: Why Half the WWE Roster Got Jacked

2:05 Minimum Effective Dose & Recovery for Banged-Up Athletes

8:16 From 147 Pounds to Coaching Pros: Jay's Background

18:44 The CM Punk Case Study: Volume, Carbs & Sleep

26:09 The Recovery Tools That Actually Move the Needle

30:42 Body Temperature: The Metabolic Scoreboard

37:00 How to Program Cardio & HIIT for Busy People

43:32 Warm-Ups, Rep Brackets & the Logbook Trap

54:55 Balancing Aesthetics & Athleticism in a Program

60:49 What Dogs Taught Jay About Presence

63:59 Building the Perfect Meal Plan

Connect with Jay:

Jay's site & coaching: https://jay.fit

Instagram: https://www.instagram.com/jayferruggia

YouTube: https://www.youtube.com/channel/UCUuDiUu00raDqT_MaNhx_Hw

Renegade Radio podcast (Apple): https://podcasts.apple.com/us/podcast/renegade-radio-with-jay-ferruggia/id853941025

Renegade Radio podcast (Spotify): https://open.spotify.com/show/0Hw50ZFA1gOfC1vQEZDI3u

Bloodwork without the doctor's visit → https://ddtmtd.co/Amplify

Third-party tested research compounds from Janus Optimize → Use code DDTSkool

Join the DDT Method Skool community → https://ddtmtd.co/skool

Work with a DDT Method Coach → https://ddtmtd.co/apply

Max Bertolino runs compounds himself at the doses the studies actually used, then pulls blood. In this episode he and Drew go head to head on SLU-PP-332 vs SLU-PP-915 — why the reported dosing range on 332 spans a thousandfold, what actually happens at the top of that range, and why 915 appears to do the same job at a fraction of the dose with cleaner blood work and none of the hydrazide risk.

From there it opens into the rest of the new metabolic drugs. Max breaks down the estrogen-related receptor mechanism behind the exercise mimetics — why they shift fuel selection toward fat, why they drive GLUT4 and mitochondrial density independent of training, and why the gyno panic around 332 was never pharmacologically possible. He explains ATX-304 (O-304) as a pan-AMPK activator that keeps AMPK switched on by blocking the phosphatase that turns it off, and why twelve weeks at the clinical dose did nothing measurable to his hypertrophy despite everything the AMPK-versus-mTOR crowd predicted. He covers SANA (MVD1) and the futile creatine cycle — a compound whose entire mechanism is making your body waste its own energy accomplishing nothing — along with the phase one tolerability ceiling and the creatine-loading trick one user stacked on top of it.

The back half turns to what the community already runs and gets wrong. Why the SS-31 dose everyone uses was essentially picked out of the air, an order of magnitude below the studies. Why ACE-083 grows muscle volume without a matching increase in force output. Why Masteron's reputation has no pharmacological pedigree behind it. Why Boldenone is a better Primobolan than most people will admit, and why mirabegron and albuterol are the two most overlooked compounds in fat loss.

The through-line: almost every dose and every fear this community operates on was inherited rather than measured. And the single most practical warning in the hour — stack an exercise mimetic with ATX-304 while running a deep deficit on low carbs and fasted cardio, and the compounds are not what puts you on the floor. Your diet is.

TAKEAWAYS

• The dosing range on SLU-PP-332 spans a thousandfold. Only one end of it does anything.
• SLU-PP-915 does the same job at roughly a seventh of the dose — and the blood work comes back cleaner.
• Stack an exercise mimetic with ATX-304 and it won't be the compounds that put you on the floor. It'll be your diet.
• The SS-31 dose everyone runs is 2mg. The studies showing kidney benefit start at 40.
• Mirabegron is a bladder drug for old people. It burns 250 calories a day while you do nothing.

CHAPTERS

00:00 SLU-PP-332 vs SLU-PP-915: The Thousandfold Dosing Range

08:00 Why the Old Bodybuilding Compounds Are a Dead End

15:50 How Exercise Mimetics Work: ERR Activation, GLUT4 & Going Hypo

26:13 ATX-304: Pan-AMPK Activation & the Muscle-Loss Fear

33:31 Stacking ATX With SLU, MOTS-c Redundancy & the SS-31 Dose

41:16 SANA & the Futile Creatine Cycle

48:04 Myostatin Inhibition: ACE-083, Follistatin-344 & Cosmetic Muscle

56:05 Masteron, Anavar & Anadrol: What Still Earns Its Place

1:04:58 Boldenone, Beta-3 Agonism & Albuterol Over Clen

1:12:40 Where to Find Max Bertolino

FIND MAX BERTOLINO — all links verified against his own site, not taken from the transcript

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