Do Androgen Receptors Downregulate?

There is a very common misconception in the bodybuilding community that androgen receptors downregulate during a steroid cycle, or during long-term steroid use.

A plateau in muscle gain is commonly attributed to this “androgen receptor downregulation”.

If you've ever cycled anabolics, you can also attest to the fact that during a new cycle the gains always seem to come within the first 8 weeks or so, and then the weeks following that it is typical to notice a blatant diminishing returns effect.…

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