The Lab Report

Dr. Datis Kharrazian on Mitochondria, Brain Fatigue, and Autoimmunity


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Mitochondria are the powerhouses of the cell which function to make ATP and energy. Their role in chronic disease is widely studied and often overlooked. Symptoms and root causes of mitochondrial dysfunction can be difficult to pinpoint in your patients. When it comes to relating this to brain fatigue or thyroid dysfunction, Dr. Datis Kharrazian is an expert. He has written several books and lectured extensively on these topics.

In this episode, Dr. Kharrazian outlines his approach to chronic disease using the lost art of the physical exam, laboratory assessments, and a review of current literature. Learn how he uses subtle clues to uncover root causes and what he does to improve patient outcomes.

 “One of your best windows to assess mitochondrial compromise is to look at the brain.” – Dr. Datis Kharrazian

Today on The Lab Report:

  • 2:40 Meet Dr. Datis Kharrazian
  • 10:10 Mitochondrial dysfunction and how it affects the brain
  • 13:00 Symptoms, causes, and treatment of brain fatigue
  • 19:00 The functional neurological exam
  • 21:00 Stimulating neurologic mitochondrial biogenesis
  • 22:50 Working up brain fatigue with functional labs and physical exam
  • 28:05 Functional medicine approach to autoimmune thyroid disease
  • 31:32 Intestinal permeability, gluten, and lectins in autoimmunity
  • 39:00 Using stool testing and food antibody testing to assess immune tolerance
  • 43:40 Kharrazian explains his extensive new patient work up
  • 48:35 The Kharrazian Institute
  • 53:25 The Fireball

Additional Resources:

Kharrazian Resource Center

Kharrazian Institute

Why Isn't My Brain Working?

Why Do I Still Have Thyroid Symptoms When My Lab Tests Are Normal?

Immunological Reactivity Using Monoclonal and Polyclonal Antibodies of Autoimmune Thyroid Target Sites with Dietary Proteins

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Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected].

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