• Insulin resistance and type 2 diabetes are diseases of excess fat burning and impaired glucose metabolism

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Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-113-carbohydrates-dont-cause-insulin-resistance-or-diabetes-evidence-for-the-bioenergetic-view

Timestamps:

0:00 – intro

1:28 – what the mainstream view of insulin resistance gets wrong when it comes to what causes insulin resistance and diabetes

3:24 – glycolysis and fat oxidation are favored, and glucose oxidation is inhibited in insulin resistance and diabetes

8:39 – what happens to glucose in diabetic cells

10:32 – why insulin resistance is a symptom rather than the driver of diabetes

12:55 – research showing that insulin resistance is driven by poor glucose metabolism

20:50 – impaired glucose uptake is not caused by excess insulin; fat-burning and impaired glucose metabolism are the culprits 

27:10 – the problems with relying on fat oxidation over carbohydrate oxidation 

30:43 – how increasing blood glucose levels or increasing insulin can restore normal glucose uptake in diabetes

35:28 – how insulin actually lowers blood sugar and the effects of insulin on cortisol and other stress hormones

37:16 - why fatty acid oxidation is NOT the underlying cause of insulin resistance

40:06 – factors that support or block mitochondrial respiration

41:20 – how excess fatty acid oxidation contributes to the pathology of insulin resistance and can impair glucose metabolism over time

42:49 - how insulin actually lowers blood sugar and the effects of insulin on cortisol and other stress hormones (cont.)

47:08 – why we don’t want to blame insulin for insulin resistance and what really causes high fasting blood glucose

49:22 – how low-carb diets increase stress hormones and decrease insulin sensitivity