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Click here to check out the show notes:

Timestamps:

0:00 – intro 

1:12 – overview of endogenous vs. exogenous oxalates 

5:46 – how much oxalate comes from endogenous production vs. diet 

9:14 – when endogenous oxalate production matters more than dietary oxalate 

15:03 – rare genetic disorders that cause excessive oxalate production: primary hyperoxaluria 

22:36 – the pathways in the liver that lead to oxalate production 

32:41 – other biochemical pathways involved in endogenous oxalate production 

41:19 – deranged metabolic function as a primary driver of glyoxal production and lipid peroxidation 

45:14 – the extent to which glycine and vitamin C contribute to endogenous oxalate formation 

48:00 – how much does hydroxyproline contribute to oxalate production? 

52:06 – the primary precursor to oxalate that’s often ignored (glyoxal) 

55:08 – how oxidative stress drives oxalate production and how antioxidants help 

1:01:20 – what causes the high oxalate levels seen in type 2 diabetes, obesity, cardiovascular disease, and non-alcoholic fatty liver disease (NAFLD)? 

1:11:16 – the protective effects of glycine in states of excess oxalate production 

1:15:54 – elevated stress hormones and gluconeogenesis increase oxalate production 

1:22:43 – nutrient deficiencies that contribute to oxalate issues (vitamin B1, vitamin B6, and zinc)