Why glucose and fructose are not the primary drivers of AGE formation

Whether blood sugar spikes cause glycation

How fats and ketones can cause glycation

What’s really responsible for glycation in type 2 diabetes

Whether fructose causes more glycation than glucose

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes:

Timestamps:

0:00 – intro 

0:46 – common beliefs about carbohydrates and glycation 

2:35 – what are glycation and advanced glycation end products? 

6:57 – the process of glycation from glucose 

9:30 – is sugar the only source of AGEs? 

15:00 – primary drivers of glycation: dicarbonyls 

19:30 – how fatty acids, amino acids, and ketones cause AGE formation 

21:23 – how increased gluconeogenesis on low-carb diets increases AGE formation 

22:53 – glucose metabolism produces very few glycation products in the context of a healthy metabolism 

25:33 – omega-6s form AGEs more than 10x faster than glucose 

28:24 – the role of ALEs (advanced lipoxidation end products) in glycation and chronic disease 

30:36 – whether blood sugar spikes cause glycation 

38:52 – whether fructose causes more glycation (or fructation) than glucose 

47:05 – can glycation from fructose (fructation) be measured, and does this matter? 

52:06 – problems with research looking at fructose’s AGE formation in animal models