How glucose and insulin decrease glycation

Why ketogenic diets can be worse than high-carb diets when it comes to AGE formation

How autophagy helps to clear AGEs, but increasing autophagy is not the answer

The true primary drivers of AGE accumulation

The best diet and supplements for minimizing glycation

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Click here to check out the show notes:

Timestamps:

0:00 – intro 

0:57 – how glycation products are detoxified and cleared from the body 

4:03 – glycation detoxification is impaired by oxidative stress and inflammation, as seen in type 2 diabetes 

7:56 – the benefits of carbohydrates for the detoxification of glycation products 

10:42 – the benefits of insulin for the detoxification of glycation products 

12:45 – how AGEs are cleared 

14:36 – increasing autophagy via hormesis is not the answer for clearing AGEs 

19:09 – autophagy can drive disease 

20:50 – ATP protects against oxidative stress and allows for proper autophagy when needed 

24:37 – impaired mitochondrial along with fatty acid oxidation impairs autophagy and increases oxidative stress 

26:54 – carbohydrates do NOT inhibit autophagy 

29:18 – adequate thyroid hormone supports proper autophagy 

30:15 – adequate ATP and mitochondrial function is needed for the UPS (ubiquitin proteasome system) 

32:56 – do high-carb diets actually impair metabolism and insulin sensitivity 

35:26 – is fructose really worse for blood sugar regulation and glycation? 

37:16 – are low-carb or ketogenic diets the solution to reduce glycation? 

40:32 – increased glycation and oxidative stress on ketogenic diets 

44:09 –low-carb diets don’t prevent glucose exposure 

47:56 – there are still considerable insulin and glucose excursions on low-carb diets 

50:06 – gluconeogenesis leads to same glycolytic intermediates as glucose metabolism 

51:52 –the main driver of AGE formation and impaired AGE clearance 

53:40 – the role of vitamin B1 (thiamine) and mitochondrial energy production in decreasing AGEs 

56:27 –endotoxin as a driver of glycation and increased AGE production 

58:12 – hypothyroidism as a driver of glycation and AGE accumulation 

59:37 – dietary solutions for reducing glycation and AGEs 

1:03:33 – how to support the glyoxalase pathway to support the detoxification of glycation products 

1:05:56 – avoid calorie restriction, low-carb diets, fasting, resveratrol, cold exposure, excess exercise, and iron overload to decrease glycation and AGEs 

1:07:33 – iron as a double-edged sword for oxidative stress