October 14, 2025

Ep. 142: The Science of Hangovers: What Alcohol Really Does to Your Body

28 minutes

Sara dives into one of the most unforgettable parts of drinking → hangovers. From her worst-ever hangover in Punta Cana to the subtle shame-filled Sundays that followed too many nights out, Sara breaks down how hangovers evolved throughout her drinking years and how they became one of the biggest motivators for her sobriety.

She doesn’t stop at personal stories. Sara also explores the science of hangovers: what’s actually happening inside your body and brain when you’re feeling miserable the next day. You’ll learn why alcohol leads to dehydration, inflammation, anxiety, and that 3 a.m. wake-up, plus why “hair of the dog” only keeps the cycle going.

If you’ve ever wondered why hangovers hit so hard or need a vivid reminder of what you’re leaving behind, this episode is your reality check and your motivation to keep choosing a hangover-free life.

00:00 Introduction to the Podcast and Today's Topic

02:28 The Worst Hangover Experience

09:00 Evolution of Hangovers Over the Years

15:34 The Science Behind Hangovers

25:06 Conclusion

💡 What You’ll Learn

Sara’s most vivid hangover story and why it keeps her sober today

How her hangovers evolved from college through adulthood

The emotional side of hangovers → anxiety, shame, and isolation

The six science-backed reasons we experience hangovers

Dehydration and electrolyte loss

Acetaldehyde toxicity

Inflammation and immune response

Blood sugar drops

Disrupted sleep and neurotransmitter imbalance

The emotional fallout (“hangxiety”)

Why hangovers are a warning sign, not the price of fun

🎧 Mentioned in this episode:

Path to Power Quiz - CLICK HERE to take the Path to Power Quiz and get your personalized podcast playlist today.

Refresh & Reboot: 30 Day Alcohol Free Challenge - CLICK HERE to start your self guided 30 day alcohol free challenge today.

🧠 Sources & Further Reading

If you want to dig deeper into what’s really happening in your body during a hangover — from dehydration to acetaldehyde toxicity — here are the research-based resources referenced in this episode:

Mayo Clinic: Hangovers: Symptoms and Causes

Explains how dehydration, electrolyte imbalance, and poor sleep contribute to hangover symptoms.

National Institute on Alcohol Abuse and Alcoholism (NIAAA): Hangovers Fact Sheet

Overview of the biochemical and neurological effects of alcohol withdrawal and hangovers.

Harvard Health Publishing (2022): Why hangovers hurt and how to help

Discusses blood sugar drops, dehydration, and sleep disruption caused by alcohol.

Wiese, J.G., Shlipak, M.G., & Browner, W.S. (2000): The Alcohol Hangover. Annals of Internal Medicine

Foundational research describing the physiological mechanisms behind hangover symptoms.

Penning, R., McKinney, A., & Verster, J.C. (2010): The Pathophysiology of Alcohol Hangover. Current Drug Abuse Reviews

Details inflammatory and immune system responses linked to acetaldehyde toxicity.

Stephens, R., Grange, J.A., Jones, K., & Heffernan, T.M. (2014): A Review of the Cognitive and Neurobiological Effects of Alcohol Hangover. Addiction

Explores how alcohol affects neurotransmitters, sleep quality, and cognitive performance.

Quertemont, E. (2004): Acetaldehyde: A Biochemical Marker for Alcohol Addiction? Addiction Biology

Examines how acetaldehyde interacts with dopamine and reward pathways in the brain.

International Agency for Research on Cancer (IARC) (1999): Re-evaluation of Some Organic Chemicals. IARC Monographs, Vol. 71

Classifies acetaldehyde as a Group 1 carcinogen. The same category as tobacco and asbestos.

NIAAA: Alcohol Metabolism: An Update

Explains how ethanol is converted into acetaldehyde and then into acetate in the liver.

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🌟 Want deeper support on your alcohol-free journey?

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👉 Learn more and join us here: https://nomorewasteddays.co/day-makers-community/

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By Sara Kaufman-Bradstreet

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