Dr. James Downing is the CEO of St. Jude Children's Research Hospital, one of the best-known and most impactful hospitals in America. St. Jude has an annual operating budget of roughly $1.4 billion, and among other achievements, has helped raise the overall childhood cancer survival rate from 20% to more than 80%. James joins Adam to share his journey and his best lessons and advice. James and Adam discuss a wide range of topics: leadership, career development, innovation, decision-making, and more.