What if chronic disease isn't a single problem—but a breakdown across multiple biological networks?

In this live Evolution of Medicine Podcast episode from the IFM conference, James Maskell speaks with Dr. Kristine Burke about the rapid transformation of functional medicine and its growing integration into mainstream healthcare systems.

They explore why inflammatory markers like CRP took decades to enter standard practice, and how this reflects a broader challenge in translating research into real-world medicine.

Dr. Burke shares her journey from conventional family medicine into functional medicine after seeing patients experience major cardiovascular events despite guideline-based care. This led her to focus on residual risk, root causes, and systems biology.

The conversation also covers emerging biomarkers such as SII, SIRI, and suPAR, which may help detect systemic chronic inflammation and disease risk earlier than traditional approaches.

A major theme is the shift toward network-based care—where clinicians collaborate through shared systems, multidisciplinary teams, and structured data to improve outcomes in complex chronic disease.

The episode closes with reflections on global growth in functional medicine, the urgency of early intervention in cognitive decline ("time is brain"), and the expanding role of clinical collaboration in shaping the future of healthcare.

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About the Guest:

Dr. Kristine Burke is a physician trained in conventional family medicine who transitioned into functional medicine after recognizing the limitations of guideline-based approaches in managing chronic disease.

She specializes in cardiovascular health, complex chronic illness, and cognitive decline, with a strong focus on systems biology and root-cause medicine.

Dr. Burke has contributed to the development and clinical application of functional medicine frameworks, including lifestyle-based interventions, metabolic and inflammatory risk assessment, and multi-system clinical reasoning.

She is also involved in TrueNeuro, a collaborative initiative focused on reversing and preventing cognitive decline through early intervention and systems-based care models.

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Website: https://www.jamesmaskell.com/

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LinkedIn: https://www.linkedin.com/in/jamesmaskell

YouTube: https://www.youtube.com/FunctionalForum

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Evolution of Medicine™ Mission Partners:

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Fullscript: https://goevomed.com/fullscript

Big Boost Marketing: https://goevomed.com/bigboost

Freedom Practice Training: https://goevomed.com/fpc

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PODCAST

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This podcast is produced by DrTalks.com

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What if chronic disease isn't a single problem—but a breakdown across multiple biological networks?

In this live Evolution of Medicine Podcast episode from the IFM conference, James Maskell speaks with Dr. Kristine Burke about the rapid transformation of functional medicine and its growing integration into mainstream healthcare systems.

They explore why inflammatory markers like CRP took decades to enter standard practice, and how this reflects a broader challenge in translating research into real-world medicine.

Dr. Burke shares her journey from conventional family medicine into functional medicine after seeing patients experience major cardiovascular events despite guideline-based care. This led her to focus on residual risk, root causes, and systems biology.

The conversation also covers emerging biomarkers such as SII, SIRI, and suPAR, which may help detect systemic chronic inflammation and disease risk earlier than traditional approaches.

A major theme is the shift toward network-based care—where clinicians collaborate through shared systems, multidisciplinary teams, and structured data to improve outcomes in complex chronic disease.

The episode closes with reflections on global growth in functional medicine, the urgency of early intervention in cognitive decline ("time is brain"), and the expanding role of clinical collaboration in shaping the future of healthcare.

- - - - -

About the Guest:

Dr. Kristine Burke is a physician trained in conventional family medicine who transitioned into functional medicine after recognizing the limitations of guideline-based approaches in managing chronic disease.

She specializes in cardiovascular health, complex chronic illness, and cognitive decline, with a strong focus on systems biology and root-cause medicine.

Dr. Burke has contributed to the development and clinical application of functional medicine frameworks, including lifestyle-based interventions, metabolic and inflammatory risk assessment, and multi-system clinical reasoning.

She is also involved in TrueNeuro, a collaborative initiative focused on reversing and preventing cognitive decline through early intervention and systems-based care models.

- - - - -

Social Handles:

Website: https://www.jamesmaskell.com/

X: https://x.com/mrjamesmaskell

Instagram: https://www.instagram.com/mrjamesmaskell

Facebook: https://www.facebook.com/jamesedwardmaskell/

Linkedin: https://www.linkedin.com/in/jamesmaskell

Youtube: https://www.youtube.com/FunctionalForum

- - - - -

Evolution of Medicine™ Mission Partners:

TrueNeura: https://truneura.com/trunuera

Fullscript: https://goevomed.com/fullscript

Big Boost Marketing: https://goevomed.com/bigboost

Freedom Practice Training: https://goevomed.com/fpc

- - - - -

PODCAST

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Please subscribe and share.

This podcast is produced by DrTalks.com

https://drtalks.com/podcast-service/

What if chronic disease, cognitive decline, and even trauma were not fixed conditions—but modifiable biological states?

In this Functional Forum episode, James Maskell and Matt Wiggins bring together leading clinicians and researchers to explore the frontiers of precision and functional medicine.

They discuss SUPAR, a powerful biomarker for systemic inflammation that could reshape early disease detection. The conversation then turns to a groundbreaking cognitive decline trial showing major improvements in patients treated with functional medicine protocols compared to standard care.

The episode also explores the biology of loneliness and the "cell danger response," the reversibility of trauma through epigenetic mechanisms and psychedelic-assisted therapy, and emerging ideas about measuring masculinity as a clinical health indicator.

Together, these insights point toward a future where chronic disease may be detected earlier, treated systemically, and in some cases reversed.

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About the Guests:

This episode features multiple leading voices from the Functional Forum community, including clinicians and researchers in functional and precision medicine:

Matt Wiggins – Health innovator focused on bringing advanced biomarker testing, including SUPAR, into clinical practice

Dr. Kat Toups – Clinician involved in cognitive decline research using precision functional medicine approaches

Dr. Molly Maloof – Physician and educator specializing in metabolic health, loneliness biology, and cellular stress responses

Dr. David Rabin – Psychiatrist and neuroscientist studying trauma, epigenetics, and psychedelic-assisted therapy

Dr. Brad Jacobs – Clinician exploring novel frameworks for men's health and masculinity as a clinical metric

Dr. Ryan Adler – Advocate for integrating cognitive health protocols into mainstream clinical practice

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Social Handles:

Website: https://www.jamesmaskell.com/

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Instagram: https://www.instagram.com/mrjamesmaskell

Facebook: https://www.facebook.com/jamesedwardmaskell/

Linkedin: https://www.linkedin.com/in/jamesmaskell

Youtube: https://www.youtube.com/FunctionalForum

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This podcast is produced by DrTalks.com

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What if the fastest way to grow your medical practice isn't advertising—but conversation?

In this episode of The Evolution of Medicine, James Maskell speaks with Bret Gregory, founder of DrTalks, about how podcasting is transforming the way doctors build authority, attract patients, and share medical knowledge.

They explore how DrTalks is creating a creator economy for physicians, making it easy to become a podcast guest or host while removing technical and logistical barriers. Bret breaks down a "crawl, walk, run" strategy where doctors start as guests before launching their own shows.

The conversation highlights practical tools like "signature talks," which use AI to generate compelling podcast pitches, and explains how consistency—not production scale—is what drives long-term success.

A major focus is the power of local podcasting, where doctors interview referral partners and community members to build trust, visibility, and direct patient flow.

Ultimately, this episode reframes podcasting as a foundational tool for modern medicine—one that builds authority, strengthens community ties, and helps doctors thrive in a founder-led media world.

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About the Guest:

Bret Gregory is the founder of DrTalks, a platform designed to connect doctors and patients through trusted medical content and podcasting. He is focused on building a global network that helps physicians share their expertise while also creating sustainable income streams through media and content creation. Through DrTalks, Bret has helped thousands of doctors launch podcasts, appear as guests, and build meaningful digital presence with minimal technical barriers.

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Instagram: https://www.instagram.com/bretgdrtalks/

Linkedin: https://www.linkedin.com/in/bretg/

Website: https://drtalks.com/

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Social Handles:

Website: https://www.jamesmaskell.com/

X: https://x.com/mrjamesmaskell

Instagram: https://www.instagram.com/mrjamesmaskell

Facebook: https://www.facebook.com/jamesedwardmaskell/

Linkedin: https://www.linkedin.com/in/jamesmaskell

Youtube: https://www.youtube.com/FunctionalForum

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Evolution of Medicine™ Mission Partners:

TrueNeura: https://truneura.com/trunuera

Fullscript: https://goevomed.com/fullscript

Big Boost Marketing: https://goevomed.com/bigboost

Freedom Practice Training: https://goevomed.com/fpc

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PODCAST

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This podcast is produced by DrTalks.com

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What if health is shaped less by individual optimization—and more by our relationships?

In this episode of The Evolution of Medicine, James Maskell speaks with Michael Trainer, author of Resonance, about how relationships influence biology, behavior, and long-term health.

They explore "resonance" as a state of nervous system alignment between people, and how loneliness and weak social networks contribute to chronic disease, dementia, and mental health issues. Trainer shares personal experiences from caring for his father, overcoming OCD, and finding healing through cultural immersion in Sri Lanka.

The conversation also examines "network sufficiency," community as medicine, and why AI cannot replace human relational intelligence in healthcare.

Ultimately, this episode reframes health as something co-created through connection, trust, and community.

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About the Guest:

Michael Trainer is an author, speaker, and founder focused on relational intelligence, social health, and the role of human connection in wellbeing. He is the author of Resonance, where he explores how relationships and nervous system co-regulation shape health as much as biology or behavior.

His work is informed by both personal experience—caring for his father through dementia and overcoming OCD following adolescent trauma—and global exploration, including immersive time in collectivist cultures such as Sri Lanka. Through his writing and teaching, he focuses on how individuals and communities can build deeper connections, restore emotional coherence, and strengthen the social foundations of health.

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Discover Resonance — a thought‑provoking book that explores purpose, performance, and the art of thriving. Learn more today at resonance.biz.

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Social Handles:

Website: https://www.jamesmaskell.com/

X: https://x.com/mrjamesmaskell

Instagram: https://www.instagram.com/mrjamesmaskell

Facebook: https://www.facebook.com/jamesedwardmaskell/

Linkedin: https://www.linkedin.com/in/jamesmaskell

Youtube: https://www.youtube.com/FunctionalForum

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Evolution of Medicine™ Mission Partners:

TrueNeura: https://truneura.com/trunuera

Fullscript: https://goevomed.com/fullscript

Big Boost Marketing: https://goevomed.com/bigboost

Freedom Practice Training: https://goevomed.com/fpc

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This podcast is produced by DrTalks.com

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What does it take to bring functional medicine into mainstream insurance systems?

In this episode of The Evolution of Medicine, James Maskell speaks with Dr. Robin Berzin about Parsley Health's landmark achievement: becoming the first functional medicine clinic in-network with insurance coverage for 150 million lives.

They explore how a decade of building standardized protocols, training systems, and outcomes data led to proof of both clinical results and cost savings in chronic disease care.

The conversation also unpacks what this shift means for independent functional medicine practitioners, and how AI, wearables, and direct-to-consumer testing are reshaping patient expectations and expanding the market for personalized medicine.

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About the Guest:

Dr. Robin Berzin is a physician and the founder and CEO of Parsley Health, a functional medicine and longevity clinic focused on treating chronic disease through a systems-based, root-cause approach. She has built Parsley Health into a nationally scaled clinical model that integrates evidence-based protocols, digital health tools, and outcomes tracking to deliver personalized, preventive care.

Website: https://www.parsleyhealth.com/

Facebook: https://www.facebook.com/parsleyhealth/

Instagram: https://www.instagram.com/parsleyhealth/

LinkedIn: https://www.linkedin.com/company/parsley-health/

YouTube: https://www.youtube.com/@parsleyhealth

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Social Handles:

Website: https://www.jamesmaskell.com/

X: https://x.com/mrjamesmaskell

Instagram: https://www.instagram.com/mrjamesmaskell

Facebook: https://www.facebook.com/jamesedwardmaskell/

Linkedin: https://www.linkedin.com/in/jamesmaskell

Youtube: https://www.youtube.com/FunctionalForum

- - - - -

Evolution of Medicine™ Mission Partners:

Big Boost Marketing: https://goevomed.com/bigboost

Freedom Practice Training: https://goevomed.com/fpc

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PODCAST

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This podcast is produced by DrTalks.com

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What if the future of maternal healthcare began before conception?

In this episode of The Evolution of Medicine , James Maskell and Emily Rydbom explore how nutrition, systems biology, and integrated care models are transforming pregnancy outcomes.

You'll learn how a "standard of care plus" approach—combining trimester-specific nutrition, biomarker testing, and virtual care models—has improved outcomes across multiple cohorts, including Medicaid populations.

This conversation explores how early nutritional intervention may reduce preterm birth, gestational diabetes, and other complications, while also reshaping how we think about prevention in medicine.

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About the Guest:

Emily Rydbom is a board-certified holistic nutritionist and clinical researcher working within the Grow Baby initiative, a 13–15 year program focused on improving maternal and infant health through nutrition-first, systems-based care models. She has worked extensively on integrating nutrition into obstetric care across clinical, virtual, and hybrid healthcare systems.

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Social Handles:

Website: https://www.jamesmaskell.com/

X: https://x.com/mrjamesmaskell

Instagram: https://www.instagram.com/mrjamesmaskell

Facebook: https://www.facebook.com/jamesedwardmaskell/

Linkedin: https://www.linkedin.com/in/jamesmaskell

Youtube: https://www.youtube.com/FunctionalForum

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Evolution of Medicine™ Mission Partners:

TrueNeura: https://truneura.com/trunuera

Fullscript: https://goevomed.com/fullscript

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PODCAST

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This podcast is produced by DrTalks.com

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What does the future of psychiatry look like when psychedelics, functional medicine, and trauma therapy converge?

In this episode of The Evolution of Medicine, James Maskell and Will Van Derveer, MD explore how psychedelic-assisted therapy is reshaping mental health care.

You'll learn how MDMA, psilocybin, ketamine, and emerging compounds may be used for different clinical needs, why integration is essential for lasting change, and how functional medicine can support deeper healing of both body and mind.

This conversation goes beyond treatment—it explores meaning, trauma, and the future of human transformation in medicine.

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About the Guest:

Will Van Derveer, MD is a psychiatrist and co-founder of the Integrative Psychiatry Institute. He is a leading educator in integrative and psychedelic-assisted therapy, training thousands of clinicians worldwide in functional medicine and psychedelic treatment approaches.

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Social Handles:

Website: https://www.jamesmaskell.com/

X: https://x.com/mrjamesmaskell

Instagram: https://www.instagram.com/mrjamesmaskell

Facebook: https://www.facebook.com/jamesedwardmaskell/

Linkedin: https://www.linkedin.com/in/jamesmaskell

Youtube: https://www.youtube.com/FunctionalForum

Evolution of Medicine™ Mission Partners:

TrueNeura: https://truneura.com/trunuera

Fullscript: https://goevomed.com/fullscript

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PODCAST

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This podcast is produced by DrTalks.com

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What if cannabis could support brain health and cognitive function?

In this episode of The Evolution of Medicine, James Maskell and Dr. Bonni Goldstein explore how medical cannabis interacts with the endocannabinoid system to reduce neuroinflammation and support neurological health.

You'll learn how compounds like THC, CBD, and CBG may protect the brain, the benefits of full-spectrum cannabis, and how proper dosing and medical guidance can improve outcomes safely.

This conversation offers a new perspective on cannabis as part of a holistic approach to aging, brain health, and dementia care.

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About the Guest:

Dr. Bonni Goldstein is a physician specializing in medical cannabis and its therapeutic applications. Based in California, she has treated thousands of patients using cannabinoid-based therapies and is a leading advocate for integrating cannabis into modern medical practice through education, research, and clinical care.

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Register for the Reversing Alzheimer's 2.0 Summit, running from April 11, 2026 – April 15, 2026.

Join us at https://drtalks.com/summits/alzheimers

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Social Handles:

Website: https://www.jamesmaskell.com/

X: https://x.com/mrjamesmaskell

Instagram: https://www.instagram.com/mrjamesmaskell

Facebook: https://www.facebook.com/jamesedwardmaskell/

Linkedin: https://www.linkedin.com/in/jamesmaskell

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What if cognitive decline and Alzheimer's could be reversed?

In this episode of The Evolution of Medicine , James Maskell and Dr. Kristine Burke discuss the 2026 summit's advances in precision medicine and team-based approaches to brain health.

You'll learn about a first-of-its-kind randomized trial showing measurable cognitive improvement, the importance of addressing multiple root causes, and strategies for making these interventions accessible to clinicians and patients alike.

This is a conversation about science, hope, and creating a new standard of care for cognitive decline.

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About the Guest:

Dr. Kristine Burke is a physician specializing in functional and precision medicine, focused on reversing chronic diseases including Alzheimer's and cognitive decline. She applies a systems-based approach to address root causes, helping patients achieve measurable recovery through coordinated, personalized care.

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Register for the Reversing Alzheimer's 2.0 Summit, running from April 11, 2026 – April 15, 2026.

Join us at https://drtalks.com/summits/alzheimers

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Social Handles:

Website: https://www.jamesmaskell.com/

X: https://x.com/mrjamesmaskell

Instagram: https://www.instagram.com/mrjamesmaskell

Facebook: https://www.facebook.com/jamesedwardmaskell/

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PODCAST Thank you for listening. Please subscribe and share. This podcast is produced by DrTalks.com https://drtalks.com/podcast-service/