In this episode of The Evolution of Medicine, host James Maskell interviews registered dietitian Ashley Koff about her new book Your Best Shot. The conversation explores the seismic impact of GLP-1 agonists like Ozempic and Wegovy—and how functional medicine can pivot from a "weight loss" mindset to a "weight health" approach.

Koff reframes these medications not as magic bullets, but as biosimilar hormone replacement tools that "switch on" receptor sites—without repairing the underlying ecosystem. She outlines a five-part Weight Health Hormone assessment and introduces a Physician–Dietitian–Health Coach triad to ensure sustainable outcomes.

The episode challenges practitioners to stay "agnostic about the agonist" and instead focus on metabolic repair, patient education, and structured team-based care.

About the Guest:Ashley Koff, RD is a registered dietitian and functional nutrition expert focused on metabolic health, personalized nutrition, and hormone signaling. She is the author of Your Best Shot and advocates for a "Weight Health" approach that integrates assessment, repair, and team-based implementation.

Ashley Koff, RDWebsite: https://thebetternutritionprogram.com/your-best-shot/#Order?utm_source=ig&utm_medium=social&utm_content=link_in_bio&fbclid=PAZXh0bgNhZW0CMTEAc3J0YwZhcHBfaWQMMjU2MjgxMDQwNTU4AAGn0Q9_BL_AVS4TE9ropSLtTkwP2y5sIOqKsbxZaaKPv3nNMm0Tq8QuWidcGUk_aem_U9Z5knW9eqsiMjw19fzflA

Instagram: https://www.instagram.com/ashleykoffapproved/?hl=en Facebook: https://www.facebook.com/ashleykoffapproved/ Linkedin: https://www.linkedin.com/in/ashley-koff/

James MaskellWebsite: https://www.jamesmaskell.com/ Instagram: https://www.instagram.com/mrjamesmaskell Facebook: https://www.facebook.com/jamesedwardmaskell/ LinkedIn: https://www.linkedin.com/in/jamesmaskell Thank you for listening. Please subscribe and share. This podcast is produced by DrTalks.com ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://drtalks.com/podcast-service/

In this episode of The Evolution of Medicine, host James Maskell outlines a pivotal shift for functional medicine practitioners. He argues that the era of the "artisan" solo practitioner is ending—and that survival in 2026 and beyond requires building scalable clinical infrastructure.

Maskell explains how AI-powered platforms, venture-backed telehealth companies, and direct-to-consumer lab brands are redefining patient expectations around speed, convenience, and affordability. To compete, functional medicine clinics must evolve into "full stack" models—combining objective data, team-based care, defined outcomes, and recurring membership structures.

This episode also launches a new initiative designed to help clinics operationalize that shift.

James Maskell is a healthcare entrepreneur and founder of The Evolution of Medicine. For over 20 years, he has worked to scale functional medicine through community-driven models, group visits, and practitioner infrastructure. His work focuses on moving medicine upstream—toward prevention, lifestyle intervention, and systems-based care.

Website: https://www.jamesmaskell.com/ Instagram: https://www.instagram.com/mrjamesmaskell Facebook: https://www.facebook.com/jamesedwardmaskell/ LinkedIn: https://www.linkedin.com/in/jamesmaskell Thank you for listening. Please subscribe and share. This podcast is produced by DrTalks.com ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://drtalks.com/podcast-service/

In this episode of The Evolution of Medicine podcast, host James Maskell speaks with health educator and researcher Ari Whitten about why modern medicine has failed to meaningfully prevent or reverse Alzheimer's disease—and how an evolutionary and lifestyle-based framework offers a far more effective path forward.

The conversation reframes Alzheimer's not as an inevitable consequence of aging, but as a disease of evolutionary mismatch—the result of modern lifestyles that conflict with our ancient biological design. Drawing on anthropological data, long-term population studies, and emerging research on physiological resilience, Whitten explains why building "reserve capacity" may be the most powerful strategy for long-term brain health.

Ari Whitten is a health educator, researcher, and expert in energy metabolism and human performance. His work focuses on evolutionary health, mitochondrial function, and physiological resilience as foundations for preventing chronic disease. Ari is widely known for translating complex research into actionable lifestyle strategies that help people build robust health in the modern world.

Instagram: https://www.instagram.com/theenergyblueprint/?hl=en Shop Supplements: https://theenergyblueprint.com/bf-sale-2025/ Spotify: https://open.spotify.com/show/38flatRKyeocmKUmEkVqrR Apple Podcast: https://podcasts.apple.com/us/podcast/the-energy-blueprint-podcast/id1226660198

Thank you for listening. Please subscribe and share. This podcast is produced by DrTalks.com ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://drtalks.com/podcast-service/

In this episode of The Evolution of Medicine podcast, host James Maskell speaks with Dr. Matthew Bernstein about the emerging field of metabolic psychiatry. They explore how addressing metabolic health—particularly through ketogenic diets—can treat and, in some cases, reverse serious mental health conditions that conventional psychiatric medications often fail to resolve.

Through personal stories, clinical insights, and a forward-looking discussion on research and policy, the episode challenges the long-standing "chemical imbalance" narrative and reframes mental illness as a systemic, energy-based disorder rooted in metabolic dysfunction.

James Maskell interviews Dr. Matthew Bernstein on metabolic psychiatry, ketogenic diets, and the future of mental health care, exploring how metabolic health can reverse depression, bipolar disorder, and psychosis on The Evolution of Medicine Podcast.

Dr. Matthew Bernstein is a psychiatrist and pioneer in metabolic psychiatry. After a family health crisis involving his sons' diagnosis of PANS (Pediatric Acute Neuropsychiatric Syndrome), he shifted away from medication-centric psychiatry toward addressing root causes such as metabolic dysfunction, inflammation, and immune dysregulation. He is the founder of Accord, an immersive metabolic health program near Boston.

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Instagram: https://www.instagram.com/mrjamesmaskell

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Linkedin: https://www.linkedin.com/in/jamesmaskell

Thank you for listening.

Please subscribe and share.

This podcast is produced by DrTalks.com ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

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In this solo episode of The Evolution of Medicine, host James Maskell explores emerging conversations in healthcare, focusing on low-level toxicity, electromagnetic fields (EMFs), and practical ways clinicians can support patients in reversing chronic illness.

The episode highlights personal experiences, clinical observations, and actionable strategies for reducing "electrosmog" or electromagnetic fog exposure in everyday life, alongside broader insights into optimizing environmental health for longevity and functional medicine.

James Maskell explores EMFs, low-level toxicity, and "electrosmog" in functional medicine, sharing practical strategies to reduce exposure, optimize patient health, and support longevity on The Evolution of Medicine Podcast.

James Maskell is the founder and host of The Evolution of Medicine Podcast, focused on functional, integrative, and longevity medicine. He explores innovations in healthcare, chronic illness reversal, and strategies for building thriving practices and healthy communities.

Website: https://www.jamesmaskell.com/

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Instagram: https://www.instagram.com/mrjamesmaskell

Facebook: https://www.facebook.com/jamesedwardmaskell/

Linkedin: https://www.linkedin.com/in/jamesmaskell

Thank you for listening.

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This podcast is produced by DrTalks.com ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

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In this episode of The Evolution of Medicine, host James Maskell sits down with researcher and author Dawson Church to explore the powerful intersection of mindset, spiritual intelligence, and brain health.

The conversation challenges the idea that Alzheimer's is an inevitable genetic destiny, highlighting how lifestyle, thought patterns, and emotional practices can influence disease progression.

You'll learn about the latest research showing how positive thinking, meditation, and relational spirituality can suppress Alzheimer's gene expression, stimulate neuroplasticity, and improve memory and learning centers. Church also shares practical strategies for caregivers, emphasizing compassion, shared meditation, and building supportive connections to reduce stress and protect longevity.

Dawson Church and James Maskell explore mindset, spiritual intelligence, meditation, and lifestyle strategies to prevent Alzheimer's, boost brain health, and support caregivers on The Evolution of Medicine Podcast.

Dawson Church is a researcher and author specializing in the interplay of mindset, spirituality, and brain health. He is known for exploring how meditation, relational spirituality, and positive emotional practices influence gene expression, neuroplasticity, and Alzheimer's prevention.

Website: https://dawsonchurch.com/ Facebook: https://www.facebook.com/dawsonchurch/

James Maskell: Website: https://www.jamesmaskell.com/ X: https://x.com/mrjamesmaskell Instagram: https://www.instagram.com/mrjamesmaskell

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This podcast is produced by DrTalks.com ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://drtalks.com/podcast-service/

This week on the podcast, we welcome Patti Lemer who last year gave me the opportunity to do something I've never done before, write the foreword to her new book. Patti is an OG in the autism space and a true pioneer in understanding the environmental drivers impacting children's health. The book is Total Load Theory. Many people know Patti from her earlier work, Outsmarting Autism, which drew from decades of hands-on experience working with kids on the spectrum. Long before environmental illness entered mainstream conversation, Patti was already mapping the terrain, looking at toxic burden, immune stress, and the cumulative impact of modern life on developing nervous systems. As the cultural conversation shifted and the term "Outsmarting Autism" began to feel limiting, Patti revisited the work with fresh eyes. The result is Total Load Theory – a reframing grounded in functional medicine's understanding of total allostatic load: the combined environmental, biochemical, infectious, emotional, and physiological burdens our children are carrying.

To start the year, I would love it if you could find 10 minutes today to read what I believe is the most important blog I've written. It contextualizes the importance of both my first book, The Evolution of Medicine and my second, The Community Cure, to now what I believe is the most important moment and mission of our time… I also reviewed the incredible recent Lyme Disease Roundtable that probably should have been 30 years ago, but it is exciting to see something come into light that has been hidden to health seekers and clinicians alike. It sets up our community for leadership on this topic for the next decade.

This week on the Evolution of Medicine podcast, we're exploring what may be the most natural, and most underutilized, home for precision brain health: senior living. Earlier this year, I was introduced to Doug Motter, President of Homestead Village in Pennsylvania. For the past 27 years, Doug has been guiding a 600-resident senior living community with a clear north star: health, dignity, and longevity. He joins me on the podcast alongside Hal Cranmer, CEO of A Paradise for Parents, a five-location senior living organization in Arizona. While their communities are different, Doug and Hal share one powerful thing in common: They are innovating at the intersection of senior living and precision brain health. In this conversation, we explore how both leaders were influenced by the work of Dr. Dale Bredesen, and how they've each taken meaningful steps to bring proactive, root-cause brain health approaches into senior living environments—places traditionally designed for management of decline, not reversal. This topic is close to my heart. It's personal, not just as someone building in this space, but as someone thinking about where our parents, and eventually we ourselves, might want to live in our later years. What makes this conversation so exciting is that it clearly shows why senior living may be the ideal setting for precision brain health:

• You have people who need this level of care

• You have built-in community and connection

• And you have the opportunity to deliver group-based, proactive brain health at scale

On the podcast, we also announce an exciting new partnership between Homestead Village and TruNeura, where we'll be deploying a group-focused precision brain health program, in collaboration with Turnpaugh Health & Wellness, a six-location, 20-provider functional medicine clinic serving Central Pennsylvania. This episode is a glimpse into what's possible when senior living shifts from custodial care to cognitive optimization, community, and purpose. Listen in if you're:

• In senior living and curious about the future of brain health
• A functional or integrative clinic interested in partnering with senior communities
• Or simply thinking about what "aging well" could really look like

If you're interested in exploring a partnership with a senior living center or bringing precision brain health into this setting get in touch with us and book a concierge call to learn more. This is the future. And it's already beginning.

This week on the podcast we feature Dr. Kirstie Lawton, Founder of Food for the Brain Foundation and a virtual brain health clinic in the UK focused on ALS (Lou Gehrig's Disease) which in the UK is called "Motor Neurone Disease" (MND) This is a hot topic in the UK as there has been a flurry of cases and concern about MND in the professional rugby players community. In this podcast you will learn:

• Is there hope for MND / ALS and what role for nutrition?
• Lessons from delivering a completely virtual brain clinic
• How science and survival of MND / ALS is evolving

Listen wherever you listen to your podcast or watch the full interview on our YouTube channel.