Dr. Aubrey de Grey is a biomedical gerontologist and the founder of the SENS research foundation which aims to find technologies that can repair the various types of damage that occur during the aging process. In this episode Rhonda and Aubrey discuss the types of damage that cause aging, how aging results in a decrease in the capacity to repair damage, what role epigenetics play in aging, how people age at different rates, chronic inflammation as a driver of aging, factors that are in young blood that repair damage, the role of nutrition in aging, and recent technologies such as CRISPR, induced pluripotent stem cells that will advance anti-aging research and more. You can find Aubrey on twitter at @aubreydegrey, and his foundation at www.sens.org.

Dr. Aubrey de Grey

Dr. Aubrey de Grey is a biomedical gerontologist and the founder of the SENS research foundation which aims to find technologies that can repair the various types of damage that occur during the aging process.

In this episode, we discuss...

• 00:00:00 - Introduction
• 00:02:27 - How to understand aging
• 00:08:14 - Epigenetic modifications accommodate cellular aging
• 00:18:24 - Inflammation is a double-edged sword
• 00:24:00 - Parabiosis has the potential to slow aging
• 00:31:35 - Lifestyle factors can only extend lifespan so far
• 00:36:49 - Future of Crispr/Cas9 in aging research
• 00:40:56 - Utilizing pluripotent stem cells from the placenta

You can find Aubrey on Twitter at @aubreydegrey, and his foundation at www.sens.org.

If you're interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/aubrey-de-grey

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Dr. Rhonda Patrick answers some of the most popular questions regarding vitamin D including:

• (00:00) Introduction
• (02:22) How do you decide how much vitamin D to supplement with?
• (12:51) Is it possible to get too much vitamin D?
• (20:52) Is there a difference between vitamin D made from the sun versus a supplement?
• (24:43) What form of vitamin D is more bioavailable or absorbed better?

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

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Dr. Rhonda Patrick answers some of the most popular questions regarding vitamin D including:

- How she decides how much vitamin D to supplement with

- Can you get too much vitamin D

- Is there a difference in vitamin D made from the sun versus a supplement

- What form of vitamin D is more bioavailable or absorbed better.

Dan Pardi

Dr. Dan Pardi researches sleep neurobiology and is a co-founder of Dan's Plan, an online wellness and technology company.

In this episode, we discuss...

• (00:00) Introduction
• (03:27) Circadian rhythms are key to health
• (07:07) Artificial lights suppress melatonin production
• (12:04) Sleep clears toxins from the brain
• (16:14) Sleep deprivation increases appetite and decreases energy expenditure
• (24:09) Sleep is critical for creating long-term memories
• (31:29) Blue light can reset circadian rhythm in the Antarctic winter
• (36:57) Long-term exercise improves sleep quality in women
• (44:43) Sleep deprivation worsens decision-making
• (51:02) Practices that encourage healthy sleep
• (53:57) A healthy diet supports good sleep
• (59:59) Dan's plan bridges the gap between research and your personal health

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

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Dan Pardi is a Ph.D candidate that researches sleep neurobiology at Stanford and University of Leiden. He is also co-founder of Dan’s Plan, an online wellness and technology company. In this podcast Rhonda and Dan discuss what the determinants of good sleep are including duration, timing and intensity,the major causes of less sleep in our society, the consequences of sleep loss including decreased purging of toxic substances from the brain, damage to neurons that signal to the brain to stay awake (and how this leads to that feeling that you need coffee in the morning), increased incidence of chronic diseases such as cancer and type 2 diabetes, cognitive and behavioral impairments, the impact on eating behaviors and weight gain. We also discuss what the optimal amount of sleep is, the importance of sleep timing, and keeping the same schedule as well as other ways to improve sleep.

Tim Ferriss, notorious self-experimenter, three-time New York Times bestselling author, an angel investor, startup advisor, and much, much, much more. Full audio transcript available at: http://wwww.foundmyfitness.com/timtranscript

Tim Ferriss

Tim Ferris is a notorious self-experimenter, three-time New York Times bestselling author, angel investor, startup advisor, and much, much, much more.

In this episode, we discuss...

• (00:00) Introduction
• (02:29) Oxytocin, vasopressin, and the neuroendocrine basis of pair bond formation
• (05:54) Tim's self-experimentation with the ketogenic diet and the biomarkers he measures daily
• (14:55) Can a ketogenic diet reduce Alzheimer's disease risk?
• (22:14) Inflammation accelerates aging, but is necessary for tissue repair
• (26:17) Vitamin C reduces inflammation, but may also inhibit muscle growth
• (35:22) Tim describes his experience with Lyme disease
• (45:43) Rhonda talks about her experience with MRSA and antibiotics
• (48:55) Tim's personal experience with ketosis
• (55:06)The 4-Hour Body talks about improving your body's performance while doing less
• (01:02:56) How to reduce social stress by exposing yourself to similar stresses
• (01:09:52) Meditation can help you stay focused and improve production
• (01:12:40) Tim Ferriss' future plans in Hollywood

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Jim Kean

Jim Kean is the CEO of National Pro Grid League (NPGL) and founder of WellnessFX.

In this podcast Rhonda and Jim discuss the quantified self movement and the importance of measuring biomarkers more than once, the gut's role in cholesterol and serotonin in the gut versus in the brain, about the role of exercise in preventing neuroinflammation and the effects of overtraining on sex hormones.

We also chat a bit about the psychology of constructing a new, non-gender segregated, team spectator sport and bringing it to market, the factors that separate a professional spectator sport from any other form of entertainment: including patriotism, justice, and vicariousness, the mathematical nature of the sport and the floor coach's role in monitoring athletes before they start "redlining," how NPGL teams may find new ways to tune their gameplay and find an edge on the competition in the future by stepping up the use of more advanced athlete-level analytics.

In this episode, we discuss...

• (00:00) Introduction
• (01:11) Optimizing performance and health has become more accessible
• (07:18) Frequent blood tests helped Jim find his optimal level of Vitamin D
• (09:45) Jim's habits for optimizing insulin sensitivity and lean body mass
• (11:06) Exercise reduces inflammation caused by kynurenine
• (12:16) Exercise increases BCAA uptake by muscle, increasing serotonin in the brain
• (13:33) Jim Kean introduces the book, Grain Brain
• (14:32) Dysfunctional insulin receptors are found in Alzheimer's disease
• (16:11) Endotoxin reacts with LDL cholesterol to form heart disease-promoting foam cells
• (19:09) How you make a successful sport
• (29:13) What is overtraining in cross-fit and what are the consequences?

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Jim Kean is the CEO of National Pro Grid League (NPGL) and founder of WellnessFX. In this podcast Rhonda and Jim discuss the quantified self movement and the importance of measuring biomarkers more than once, the gut's role in cholesterol and serotonin in the gut versus in the brain, about the role of exercise in preventing neuroinflammation and the effects of overtraining on sex hormones, a bit about the psychology of constructing a new, non-gender segregated, team spectator sport and bringing it to market, the factors that separate a professional spectator sport from any other form of entertainment: including patriotism, justice, and vicariousness, the mathematical nature of the sport and the floor coach's role in monitoring athletes before they start "redlining," how NPGL teams may find new ways to tune their gameplay and find an edge on the competition in the future by stepping up the use of more advanced athlete-level analytics.