FoundMyFitness

Dr. Bruce Ames

In this podcast, Dr. Rhonda Patrick interviews her mentor, Dr. Bruce Ames, about his triage theory and other nutrition topics. Dr. Ames was the 23rd most-cited scientist between 1973 and 1984, which is evidence of his long and productive career investigating human health and disease. Dr. Ames continues his research expanding our knowledge of nutrients such as vitamin D and its role in Autism spectrum disorder.

In this episode, we discuss...

• (00:00) Introduction
• (04:18) Dr. Ames discovers vitamin deficiency-induced DNA damage
• (10:35) Triage theory explains nutrient rationing
• (14:37) Nutrient deficiencies cause insidious damage and accelerate aging
• (25:25) Expanding the list of essential vitamins (e.g., lutein & zeaxanthin)
• (31:05) A Western diet pattern is mostly empty calories
• (36:46) Challenges running randomized double-blind clinical trials in nutrition
• (38:12) Nutrition is not the focus of our current healthcare system
• (42:15) Dr. Ames' philosophy about healthy and delicious foods

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information on triage theory, longevity & micronutrients straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

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In this podcast Dr. Rhonda Patrick interviews Dr. Bruce Ames about his triage theory, which he proposes that the body has developed a rationing response to shortages of micronutrients (vitamins and minerals) throughout evolution. When cells run out of a vitamin or mineral, that scarce micronutrient is allotted to proteins (in the body) essential for short-term survival. Proteins needed for long-term health, including those that protect DNA, lose out and become disabled and lead to diseases of aging. In addition they discuss how RDAs are chosen and what Bruce calls “longevity vitamins” which he calls a class of nutrients that exist mostly to prevent degenerative diseases of aging in addition to essential vitamins and minerals.

In this interview Dr. Rhonda Patrick talks to Dr. Frans Kuypers about his lab’s discovery on how the human placenta is a rich source of pluripotent stem cells and yet the placenta is thrown away after delivery. They discuss how his lab has shown that the stem cells from the placenta can be transformed into neuron-like cells, fat cells, bone cells, endothelial cells (relevant for lung and blood vessels), and liver cells. His lab also developed a technique for harvesting 5 to 7 times more hematopoietic stem cells from placenta than is currently retrieved from cord blood, a more standard, established source that is used worldwide for bone-marrow transplant.

In this interview, Dr. Rhonda Patrick talks to Dr. Frans Kuypers about his lab's discovery on how the human placenta is a rich source of pluripotent stem cells, and yet the placenta is thrown away after delivery.

In this episode, we discuss...

• (00:00) Introduction
• (04:39) The human placenta as a source of hematopoietic cells
• (11:30) Pluripotent cells can differentiate into any cell in the human body
• (13:03) Public banking of abundant pluripotent placental stem cells
• (18:06) Therapeutic applications of stem cells
• (22:56) Stem cells as part of a physician's toolkit
• (28:56) Epigenetics of induced pluripotent stem cells
• (34:49) Biogenerators could use young cells to produce growth factors and other chemicals
• (38:36) Transferring blood from young mice into old mice regenerates tissues using GDF11
• (43:32) Opportunities and challenges of banking stem cells
• (52:49) Stem cells could eliminate deaths due to lack of bone marrow donors
• (56:37) The way we fund research isn't optimal for society

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

In this interview Dr. Rhonda Patrick talks to Dr. Frans Kuypers about his lab’s discovery on how the human placenta is a rich source of pluripotent stem cells and yet the placenta is thrown away after delivery. They discuss how his lab has shown that the stem cells from the placenta can be transformed into neuron-like cells, fat cells, bone cells, endothelial cells (relevant for lung and blood vessels), and liver cells. His lab also developed a technique for harvesting 5 to 7 times more hematopoietic stem cells from placenta than is currently retrieved from cord blood, a more standard, established source that is used worldwide for bone-marrow transplant.

In this podcast I interview Dr. George A Brooks, an expert in exercise physiology and lactate metabolism. Lactate, a once demonized molecule thought to form lactic acid and become a dead-end toxic metabolite, has been vindicated by the work of Dr. Brooks, his colleagues, and others. Lactate has been shown not be the cause of muscle fatigue, but to actually be a source of energy itself, even being metabolized greedily with a greater degree of preference than many other more well-known sources of energy, such as glucose.

Recent research has demonstrated that this lactate metabolism pathway has a very special importance in situations of

traumatic brain injury, which is an area of inquiry that Dr. Brooks has recently been involved with researching and we talk a little bit about during this interview.

Dr. George A Brooks

Dr. George A Brooks, an expert in exercise physiology and lactate metabolism. Lactate, a once demonized molecule thought to form lactic acid and become a dead-end toxic metabolite, has been vindicated by the work of Dr. Brooks, his colleagues, and others.

In this episode, we discuss...

• (00:00) Introduction
• (01:40) Dr. Brooks' experience as an athlete inspired his research on lactate
• (06:50) Lactate and its relationship to muscle fatigue is misunderstood
• (09:10) Adaptations to exercise improve mitochondrial functioning and lactate metabolism
• (14:14) How to use lactate threshold training to improve performance
• (23:49) Lactate improves brain health and cognitive function
• (26:45) Lactate improves outcomes of traumatic brain injury via metabolism
• (30:00) Lactate spares glucose, increasing antioxidants such as glutathione
• (42:50) Early lactate administration following a traumatic brain injury is necessary, but challenging
• (48:20) Lactate from exercise improves Parkinson's disease
• (55:00) Brain metabolism following traumatic brain injury

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

In this podcast I interview Dr. George A Brooks, an expert in exercise physiology and lactate metabolism. Lactate, a once demonized molecule thought to form lactic acid and become a dead-end toxic metabolite, has been vindicated by the work of Dr. Brooks, his colleagues, and others. Lactate has been shown not be the cause of muscle fatigue, but to actually be a source of energy itself, even being metabolized greedily with a greater degree of preference than many other more well-known sources of energy, such as glucose.

Recent research has demonstrated that this lactate metabolism pathway has a very special importance in situations of

traumatic brain injury, which is an area of inquiry that Dr. Brooks has recently been involved with researching and we talk a little bit about during this interview.

In this episode Dr. Rhonda Patrick interviews Dr. Terry Wahls about how she reversed her secondary-progressive multiple sclerosis with a micronutrient-dense diet and Paleo principles. She identified vitamins/minerals and other compounds present in vegetables/fruits that are essential for mitochondrial health, which is critical for brain function.

In this episode, we discuss...

• (00:00) Introduction
• (00:48) Dysfunctional mitochondria contribute to disease development
• (04:03) Suboptimal magnesium status is common and possibly dangerous
• (04:50) Green vegetable consumption is key to Dr. Walhs' wellness
• (06:18) The Triage theory explains how low micronutrient intake increases aging-related diseases
• (09:20) Fruits and vegetables are color-coded for the variety of micronutrients needed in our diet
• (10:35) Sulfur, found in garlic, onions, and cruciferous vegetables, is needed for mitochondrial function
• (16:55) Dr. Wahls' protocol of diet, supplements, and exercise improves fatigue in MS

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

In this video Dr. Rhonda Patrick interviews Dr. Terry Wahls about how she reversed her secondary-progressive multiple sclerosis with a micronutrient-dense diet and Paleo principles. She identified vitamins/minerals and other compounds present in vegetables/fruits that are essential for mitochondrial health, which is critical for brain function.