FoundMyFitness

By Rhonda Patrick, Ph.D.Medicine Health & Fitness Nutrition

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FoundMyFitness episodes

May 03, 2016 Ray Cronise on Cold Thermogenesis, Intermittent Fasting, Weight Loss & Healthspan
Dr. Rhonda Patrick speaks with
Ray Cronise, a former NASA material scientist and cofounder of zero
gravity, a company that offers weightless parabolic flights to
consumers and researchers. In this episode, coming at the tail end
of a rather extreme 23-day water fast for Ray, we discuss, perhaps
unsurprisingly, some of the benefits that are associated with
fasting! Ray talks about
shifting one's perspective from looking at nutrition only through
the lens of meeting day-to-day nutritional needs, and instead, also
considering optimizing metabolism for longer-term effects as
well, the importance of
thinking about longevity in the context of functional healthspan,
some of the similarities between the body’s physiological response
to heat stress, cold stress, and exercise and so much
more.
Learn more about Ray Cronise by
visiting his website at hypothermics.com
(raycronise.com) or by saying hello on twitter: twitter.com/raycronise.

Finally, Ray also has a book
available for pre-order called "Our
Broken Plate."
2 hr 5 min
March 23, 2016#023 Dominic D'Agostino, Ph.D. on Modified Atkins Diet, Ketosis, Supplemental Ketones and More
Dr. Dominic D'Agostino

This podcast is with Dr. Dominic D'Agostino, an assistant professor at the University of South Florida in Tampa and all-around expert on ketosis.

In this podcast we discuss:

(00:00) Introduction

(03:46) Ketosis has abundant therapeutic potential

(10:20) What to eat to maintain nutritional ketosis

(19:58) Does a high-fat diet harm the gut?

(29:14) Adaptations to a ketogenic diet expand mitochondrial capacity

(38:45) How the brain uses ketones

(46:36) Ketones improve Alzheimer's symptoms (unless you have an APOE4 allele)

(57:17) Are ketone supplements a "magic pill?"

(01:07:32) Why cancer cells may need sugar

(01:23:51) Metformin is more than a diabetes drug

(01:30:33) The body creates sugars while in ketosis

(01:36:21) Restricting glutamine to slow cancer growth

(01:43:24) Ketone supplements taste awful, but likely improve health

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

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1 hr 55 min
March 23, 2016 Dominic D'Agostino, Ph.D. on Modified Atkins Diet, Ketosis, Supplemental Ketones and More
This podcast is with Dr. Dominic D'Agostino, an assistant professor at the University of South Florida in Tampa and all around expert on ketosis.
In this podcast we discuss...
* Dom's efforts at teasing out the differences between induced nutritional ketosis (through a low carbohydrate, high fat diet) and ketosis from the dietary introduction of exogenous ketones, like beta-hydroxybutyrate, especially in the context of therapeutic and performance enhancing effects.
* His work on formulating ketone esters.
* The differences in tolerability between MCT (medium chain triglycerides) powders versus liquids, as well as the amount of supplemental MCT a person would need to consume in order to achieve mild ketosis without carbohydrate restriction.
* The differences between different types of ketogenic diets.
* The modified atkins diet which has been demonstrated to have similar efficacy to the classical ketogenic diet in the treatment of drug-resistant epilepsy and how it may be a slightly more practical option for achieving therapeutic nutritional ketosis.
* The importance of making the correct carbohydrate choices, even and maybe especially in the context of a ketogenic diet, with a diverse variety of raw vegetables being the most favorable.
* What keto adaptation is and what it means, at a physiological level, to be keto adapted and how this is distinguished from short periods of ketosis we experience in our day-to-day lives.
* Some of Dom's ideas around cycling various dietary strategies as a way of promoting metabolic flexibility.
* How ketones, when used as a source of energy, may result in a net reduction in the number of damaging reactive byproducts known as reactive oxygen species than what may be produced by other forms of energy metabolism while also producing more ATP from, proportionately, the same amount of oxygen.
... AND SO MUCH MORE. OH MY LORD THERE IS SO MUCH MORE. Enjoy!
1 hr 55 min
March 13, 2016#022 Peter Attia, M.D. on Macronutrient Thresholds for Longevity & Performance, Cancer & More
Dr. Peter Attia

Peter is the founder of Attia Medical, a medical practice with offices in San Diego and New York City, focusing on the applied science of longevity and optimal performance.

In addition to being a medical doctor, Dr. Attia has done research on the role of regulatory T cells in cancer regression and other immune-based therapies for cancer. Regulatory T cells have also been, in the past, referred to as suppressor T cells because of their role in actually attenuating or reducing the inflammatory response.

Dr. Attia and I share interests in all things related to longevity and healthspan, which includes the role of diet, nutrition, sleep, exercise, and stress. Dr. Attia is a medical doctor and specializes in implementing these strategies in clinical practice. You can learn more about that at his website www.attiamedical.com.

In this episode, we discuss...

(00:00) Introduction

(05:39) The difficulty of identifying longevity compounds

(08:41) The mTOR and IGF-1 growth/longevity pathways

(19:11) Preventing cell and tissue damage to live longer

(22:28) Dr. Attia's ideal diet for prolonging lifespan

(25:45) Measuring gut microbes is challenging

(35:34) Alzheimer's disease risk is more lifestyle than genetics

(42:05) Environmental triggers of Alzheimer's disease

(55:49) What prolonged fasting teaches us about metabolism

(53:36) Healing brain injury and concussion with metabolism

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
1 hr 10 min
March 12, 2016 Peter Attia, M.D. on Macronutrient Thresholds for Longevity & Performance, Cancer & More
This podcast is with Dr. Peter Attia. Peter is the founder of Attia Medical, a medical practice with offices in San Diego and New York City, focusing on the applied science of longevity and optimal performance.
You may have first heard about Dr. Attia from his two interviews that have been on the Tim Ferriss show, or from any number of popular presentations he's given that were filmed and put online. In addition to being a medical doctor, Dr. Attia has done research on the role of regulatory T cells in cancer regression and other immune-based therapies for cancer. Regulatory T cells have also been, in the past, referred to as suppressor T cells because of their role in actually attenuating or reducing the inflammatory response.
Dr. Attia and I share interests in all things related to longevity and healthspan, which includes the role of diet, nutrition, sleep, exercise, and stress. Dr. Attia is a medical doctor and specializes in implementing these strategies in clinical practice. You can learn more about that at his website www.attiamedical.com.
1 hr 10 min
February 12, 2016#021 How Cryotherapy Affects the Brain, the Immune System, Metabolism, and Athletic Performance
Dr. Rhonda Patrick explains how cold shock is a type of hormesis, which is a description of a type of stress that, in the right doses, is enough to shock the body and kick off adaptive processes and response mechanisms that are hardwired into our genes, and, once on, are able to create a resilience that actually exceeds what was needed to counter the initial stimuli.

In this episode, you'll discover:

(00:00) Introduction

(03:09) Cold exposure is good stress for the brain

(15:42) Cryotherapy reduces inflammation

(23:12) Cold exposure, weight loss, and thermogenesis

(30:45) Cold exposure increases antioxidant capacity and

(33:42) How to use cold exposure to enhance athletic performance and recovery

(52:44) Whole-body cryotherapy vs cold water immersion

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
1 hr 3 min
February 12, 2016 How Cryotherapy Affects the Brain, the Immune System, Metabolism, and Athletic Performance
This podcast has a 20-page report associated with it! Get it now at foundmyfitness.com/cryotherapy. Dr. Rhonda Patrick explains how cold shock is a type of hormesis, which is a description of a type of stress that, in the right doses, is enough to shock the body and kick off adaptive processes and response mechanisms that are hardwired into our genes, and, once on, are able to create a resilience that actually exceeds what was needed to counter the initial stimuli. Rhonda discusses how cold exposure increases norepinephrine up to 5-fold in the brain and what the temperature and duration needed to do this are, how norepinephrine has an affect on mood, vigilance, focus, and attention, how cold exposure increases cold shock proteins including one in the brain that repairs damaged synapses and in muscle prevents atrophy, how cold-induced norepinephrine lowers inflammation and pain by decreasing the levels of 3 inflammatory mediators, how chronic cold shock may increase immune cell numbers and particularly a type of immune cell that kills cancer cells, how cold exposure increases metabolic rate, the number of mitochondria, and the burning of fat, what the effects of different cold exposure temperatures and timing are on athletic performance, recovery time, and muscle mass, and the differences between various types of cold shock modalities, including cold water immersion and whole body cryotherapy.
1 hr 3 min
January 23, 2016 #020 Rich Roll on Self-Transformation, Environmental Impact of Food, and the Plant-Based Diet
Rich Roll

This podcast features Rich Roll. Rich is an author, a podcaster ("Rich Roll Podcast" on iTunes), as well as founder and first person to complete the EPIC5 Challenge. The EPIC5 challenge involves completing 5 Full Iron Distance triathlons on 5 Hawaiian islands in under a week. Rich has also been a repeated top finisher in the Ultraman World Championships in Hawaii, which is a three-day, 515km (320 mile) annual endurance race held on the Big Island of Hawaii.

You can read about Rich's journey to Ultraman competitor in his book, "Finding Ultra: Rejecting Middle Age, Becoming One of the World's Fittest Men, and Discovering Myself."

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
1 hr 40 min
January 23, 2016 Rich Roll on Self-Transformation, Environmental Impact of Food, and the Plant-Based Diet
This podcast features Rich Roll. Rich is an author, a podcaster ("Rich Roll Podcast" on iTunes), as well as founder and first person to complete the EPIC5 Challenge. The EPIC5 challenge involves completing 5 Full Iron Distance triathlons on 5 Hawaiian islands in under a week. Rich has also been a repeated top finisher in the Ultraman World Championships in Hawaii, which is a three-day, 515km (320 mile) annual endurance race held on the Big Island of Hawaii. The race is divided into three stages over three days: The first is a 6.2 mile (10-km) ocean swim, followed by a 90-mile (145-km) cross-country bike ride, with vertical climbs that total 6,000 feet. Stage two is a 171.4-mile (276-km) bike ride, with total vertical climbs of 4,000 feet. Finally, stage three is a 52.4-mile (84-km) double marathon. Each stage must be completed within 12 hours or less. You can read about Rich's journey to Ultraman competitor in his book, "Finding Ultra: Rejecting Middle Age, Becoming One of the World's Fittest Men, and Discovering Myself."
1 hr 40 min
December 25, 2015#019 Dr. Darya and Kevin Rose Talk Meditation Retreats, Diet, Seasonal Eating, and More
In this episode, Dr. Rhonda Patrick chats with Dr. Darya and Kevin Rose.

Dr. Darya Rose, PhD is a neuroscientist, author of "Foodist: Using Real Food and Real Science to Lose Weight Without Dieting," and creator of Summer Tomato, which was featured in TIME magazine's list of the web's 50 best websites in 2011.

Kevin you may know from TV, the investing world, or any of a wide variety of things he's well known for (founding digg.com, just for starters). More recently, Kevin hosts a podcast where he's had guests ranging from titans of industry like Elon Musk to notables like his buddy Tim Ferriss, multi-time New York Times best selling author, investor, self-experimenter and fellow podcaster.

In this episode, we discuss...

(00:00) Introduction

(03:23) Darya Rose talks about her 10-day silent retreat

(11:32) Mindfulness can be achieved during daily activities

(16:10) Kevin's self-experimentation with a ketogenic diet

(23:59) Rhonda's interviews with Dr. Valter Longo and Ray Cronise on fasting

(29:13) Tumeric increases the body's detoxification enzymes

(33:17) Darya's career from PhD student to health advocate

(39:32) The benefits of eating seasonally

(45:12) Technology that promotes mindfulness and productivity

If you're interested in learning more, you can read the full show notes here.

Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
54 min