The Obesity Guide with Matthea Rentea MD

GLP-1s: More Than Just a Weight Loss Drug—How They're Transforming Cardiovascular Care with Dr. Simin Lee


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Heart disease is the leading cause of death for women, fueled by the growing obesity epidemic and complex cardiometabolic issues that often fall through the cracks between primary care and specialists. The simple truth? Many women aren’t getting the support they need to protect their hearts.

Today’s guest, Dr. Simin Lee, is here to change that. A Harvard-trained cardiologist and behavioral scientist, she’s paving the way for a new kind of care with Systole Health—a first-of-its-kind virtual clinic focused entirely on women’s cardiovascular health. Through innovative group care sessions, Systole Health combines expert medical guidance with the power of community, empowering women with the knowledge, support, and personalized care plans they need to thrive.

In this episode, Dr. Lee explores how GLP-1 medications are transforming treatment for cardiometabolic health, why you need to ask about testing for lipoprotein(a), and how menopause-related hormonal shifts increase heart risks and what women can do to stay ahead of them. Don’t miss this eye-opening conversation about empowering women to take control of their heart health and bridging the gaps in traditional care.


References

https://www.systolehealth.com/


Connect with Dr. Lee:

TikTok

Instagram

Youtube

LinkedIn


Audio Stamps

00:36 - Today’s guest, cardiologist Dr. Simin Lee shares her journey into cardiometabolic health, her focus on women’s heart health, and the creation of Systole, a virtual clinic using group care to empower women.

08:10 - We learn how GLP-1 medications improve cardiometabolic and kidney health by reducing blood pressure, cholesterol, and inflammation

22:05 - Dr. Simin Lee explains the cardiometabolic changes during menopause, the potential role of hormone replacement therapy, and why early, informed conversations with doctors are essential.

30:30 - Find out how to connect with Dr. Simon Lee’s practice, Systole Health, which offers virtual women's heart health care through group-based support.


Quotes

“In the early diabetes studies, GLP-1s were showing significant heart health advantages, reducing the rates of myocardial infarctions or heart attacks, strokes, and cardiovascular death in patients with type 2 diabetes, as well as leading to

All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.

If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.com

CLICK HERE to purchase Premium Season 1 of The Obesity Guide: Behind the Curtain and unlock exclusive content! Dive into real clinical scenarios, from my personal medication journey to tackling weight loss plateaus, understanding insulin resistance, and overcoming challenges with GLP-1s. Plus, get a 40+ page guide packed with protein charts, weight loss formulas, and more. Don’t miss out—available now!

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The Obesity Guide with Matthea Rentea MDBy Matthea Rentea MD

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