If you're interested in optimising your healthspan and lifespan, this episode is not to be missed.

In the quest for longevity, the spotlight has turned to NAD+ and its precursors, NMN and NR. In this episode featuring Dr. Charles Brenner, a metabolism scientist, we dive deep into the significance of these molecules and their role in healthy aging. 

You'll discover that NAD+ (Nicotinamide Adenine Dinucleotide) is not just a trending topic but rather a crucial player in metabolism. Learn why Charles refers to it as the "central jewel of metabolism".

In the conversation, the distinction between NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) is clarified, and you'll discover which of these molecules has the best evidence-base. You'll also find out why some popular ways to increase NAD+ are an expensive waste of time.

Dr. Brenner highlights the importance of evidence-based research, citing eight randomised clinical trials demonstrating the anti-inflammatory effects of one of the NAD+ precursors in humans. One significant study focuses on peripheral artery disease (PAD), a condition affecting millions of older adults that can severely impact mobility and quality of life. 

Ypu'll also disciver why a simple functional test is a way better predictor of longevity than all of the espoensive epigenetic-focused Biological Age tests that are currently on the market.

What You'll Learn:

1. The Basics of NAD and Its Functions: Understand the foundational role of NAD in cellular metabolism and how it acts as a transmitter of high-energy electrons needed for energy production and cell functions.
2. Scientific Evidence and Research: Discover the rigor behind the clinical research of NAD and its supplements, like Nicotinamide Riboside (NR), including ongoing trials and results showing anti-inflammatory properties in humans.
3. Controversies and Misconceptions: Unpack the myths concerning longevity molecules, such as misinterpretations around resveratrol, with arguments laid out by reputable scientists like Dr. Brenner.
4. Applications in Age-Related Diseases: Explore the potential of NR supplements in addressing conditions like peripheral artery disease and its promising though variable outcomes in treating Long COVID and neurodegenerative diseases.
5. Critical Analysis of Clinical Trials: Learn about the importance of clinical integrity, unbiased research, and how independent laboratories contribute to credible scientific discoveries.

Key Takeaways:

• NAD is vital for maintaining metabolic health and managing cellular stress, which is essential for healthy aging.
• Recent clinical trials have shown promising results for NR in reducing inflammation and improving conditions related to peripheral artery disease.
• There's ongoing research into NR's benefits for cognitive function, particularly its potential effects on neurodegenerative disease.
• Supplements should be chosen carefully, preferably ones that have been tested in clinical trials to ensure efficacy and authenticity.
• The conversation between Dr. Taylor and Dr. Brenner highlights the need to critically evaluate scientific claims, especially those that are widely publicised without robust evidence.

Through the episode, Dr. Brenner provides deep insights into how NAD coenzymes operate within the body and why they're considered crucial for longevity research. Moreover, listeners are encouraged to discern meticulously between scientific fact and internet hype, ensuring they make informed decisions when considering supplements. The episode is a valuable resource for anyone interested in the intersection of biochemistry, aging, and healthspan science.

Resources

Socials: 

X: @CharlesMBrenner

LinkedIn: https://www.linkedin.com/in/charles-brenner/

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If you found this conversation valuable, consider subscribing and leaving a review on your preferred podcast platform. Your feedback helps us continue to bring you insightful discussions on important health topics.

00:11 Understanding NAD+ and Longevity Molecules

01:31 Debunking Longevity Myths

03:02 The Science Behind NAD+ and Metabolism

08:46 Clinical Trials and Evidence

09:37 Peripheral Artery Disease and NAD+

11:00 Walking Speed as a Health Indicator

13:25 Challenges with DNA Methylation Clocks

21:40 NAD+ in Metabolic Processes

23:48 The Role of NAD in DNA Repair and Cellular Health

24:09 Inflammation and Aging: The Connection

25:20 Human Longevity and Reproductive Capacity

30:02 The Hallmarks of Aging

31:11 Challenges of Living in 2025: Long COVID

31:42 Clinical Trials and NAD Supplements

34:33 The Debate on NMN vs. NR

41:58 Intravenous NAD and Its Efficacy

45:06 NAD's Role in Neurodegenerative Diseases

See omnystudio.com/listener for privacy information.

See omnystudio.com/listener for privacy information.

Carly Taylor is a Mental Fitness Coach and Counsellor, helping people to strengthen their mental fitness and live with purpose. Her work is all about prevention, giving people the tools to manage their thoughts and emotions before they reach breaking point.

To find out more about Carly, visit www.carlytaylorcoaching.com.au.
Follow her on Instagram: carly_taylor_coaching

See omnystudio.com/listener for privacy information.

Part Two of my engaging chat with Dr. Sandeep Gupta as we delve into the world of longevity, exploring a multitude of strategies designed to extend not just lifespan but healthspan as well. From the basics of supplements to advanced therapies, Dr. Gupta details a comprehensive approach to living not only longer but better.

What You'll Learn:

1. Understanding Supplements and Lifestyle: Discover the intrinsic role supplements play as secondary to beneficial lifestyle habits, emphasising that no supplement can substitute a poor lifestyle.
2. Intermittent Fasting and Diet Tips: Learn the benefits of intermittent fasting and the importance of balancing protein and fasting to optimise the mTOR pathway without over activating it.
3. Advanced Interventions: Explore hormone replacement therapy's role in improving quality of life during menopause and andropausal stages, and how these therapies are evolving.
4. Pharmaceutical Opportunities: Gain insights into the judicious use of medications such as semaglutide and manjaro for weight management and metabolic health.
5. Heavy Metals and Detoxification: Understand the impacts of heavy metals in the body, how they can disrupt enzyme functions, and effective ways to manage and detoxify them.
6. Challenges in Longevity Health: Recognise common anti-longevity habits, such as excessive alcohol consumption, and how they can hinder your overall quality of life.

Key Takeaways:

• Supplements Can't Replace Lifestyle: Emphasising good sleep, stress management, and regular exercise as the foundation of good health.
• Dietary Balance is Crucial: The right balance between protein intake and fasting periods can prevent chronic activation of growth pathways detrimental to longevity.
• Hormonal Health is Vital: Balanced hormone levels play a crucial role in longevity and quality of life, particularly as we age.
• Innovative Medications: Certain medications, carefully selected and used, can support weight management and metabolic health, crucial elements in longevity.
• Impact of Toxins: Regular detoxification and maintaining mineral balance effectively counteract heavy metal toxicity, enhancing longevity prospects.
• Live Mindfully: Reducing alcohol intake and focusing on holistic happiness can profoundly impact longevity and overall health.

Resources

To delve deeper into integrative health approaches and longevity practices, consider exploring resources and studies on metabolic syndrome, holistic care interventions, and the benefits of nature exposure.

Engage with Dr. Sandeep Gupta

About Sandeep: https://linktr.ee/drsandeepgupta

Clinic: https://www.lotusholisticmedicine.com.au/dr-sandeep-gupta/

https://www.facebook.com/drsgupta/

https://www.linkedin.com/in/drsandeepgupta/

https://www.instagram.com/drsandeepgupta/?hl=en

https://www.youtube.com/c/drsandeepgupta

https://x.com/drsandeepgupta

Support the Podcast

If you found this conversation valuable, consider subscribing and leaving a review on your preferred podcast platform. Your feedback helps us continue to bring you insightful discussions on important health topics.

Join the conversation on living a vibrant, balanced life, rich in health and vitality that allows you to enjoy more years of joyful living.

Share this episode with someone who might benefit from these insights—because understanding integrative health can make all the difference.

00:00 Introduction to Supplements and Longevity

00:44 The Role of Lifestyle in Longevity

03:05 Intermittent Fasting and Its Benefits

03:59 Balancing Protein and mTOR Pathway

06:24 Practical Tips for Intermittent Fasting

11:02 Advanced Interventions: Hormone Therapy

16:11 Bioidentical Hormone Replacement Therapy

22:07 The Impact of Hormones on Mental Health

23:07 Exploring Pharmaceutical Interventions

23:45 Understanding Cardiovascular Health

28:05 Metabolic Health and Weight Loss Drugs

33:54 Mitochondrial Support and NAD

38:40 Heavy Metals and Detoxification

42:34 Biggest Anti-Longevity Habit

See omnystudio.com/listener for privacy information.

See omnystudio.com/listener for privacy information.

In this episode, Carly reflects on an idea that maybe we don’t need to explain or problem solve everything we feel. Drawing on Japanese Psychology and Morita Therapy, she explores what it means to accept our humanness rather than fight against it.

Carly Taylor is a Mental Fitness Coach and Counsellor, helping people to strengthen their mental fitness and live with purpose. Her work is all about prevention, giving people the tools to manage their thoughts and emotions before they reach breaking point.

To find out more about Carly, visit www.carlytaylorcoaching.com.au.
Follow her on Instagram: carly_taylor_coaching

See omnystudio.com/listener for privacy information.

In this insightful discussion, I chat with Dr. Sandeep Gupta, a proponent of integrative medicine and longevity health. We explore the evolving landscape of healthcare, discuss the limitations of the traditional medical system, and delve into the holistic approaches to health that focus on both healthspan and lifespan.

What You'll Learn:

1. The Shift to Integrative Medicine: Discover why Dr. Gupta transitioned from traditional pathways to focus on integrative and holistic approaches, driven by personal experiences and the need for a comprehensive view of health.
2. Challenges in Traditional Medicine: Uncover the stigmas associated with holistic health approaches in the conventional medical setting and how these have historically been viewed by the medical community.
3. Medicine 3.0 and Longevity: Understand Dr. Gupta's focus on healthspan and longevity, emphasising quality years of life filled with passion, joy, and meaning over merely extending lifespan.
4. Metabolic Health and Chronic Diseases: Learn about the significance of metabolic health, its impact on major diseases, and how insulin resistance syndrome underpins many health issues.
5. Diet and Longevity: Explore dietary recommendations for longevity, recognising the absence of a one-size-fits-all diet, and the importance of reducing sugar and refined carbohydrates.
6. Muscle Mass and Health: Grasp the crucial role of maintaining muscle mass, its anti-inflammatory benefits, and its significance in preventing sarcopenia and indirectly reducing risks for major health disorders.

Key Takeaways:

• Integrative medicine can offer a more complete approach to health, focusing not only on treating diseases but promoting overall well-being and longer healthspans.
• Traditional medicine often emphasises treatment of disease over prevention and maintenance of optimal health, a paradigm explored through Medicine 3.0.
• Metabolic syndrome is a silent precursor to many chronic illnesses, and dietary choices play a crucial role in managing this risk.
• Muscle health is vital; maintaining muscle mass as we age can prevent systemic issues and chronic disease.
• A balanced diet rich in diverse, colourful foods can bolster metabolic health and support a robust microbiome.
• Grounding and nature exposure are gaining recognition for their potential health benefits, including reducing inflammation and improving mental well-being.

Resources

To delve deeper into integrative health approaches and longevity practices, consider exploring resources and studies on metabolic syndrome, holistic care interventions, and the benefits of nature exposure.

Engage with Dr. Sandeep Gupta

About Sandeep: https://linktr.ee/drsandeepgupta

Clinic: https://www.lotusholisticmedicine.com.au/dr-sandeep-gupta/

https://www.facebook.com/drsgupta/

https://www.linkedin.com/in/drsandeepgupta/

https://www.instagram.com/drsandeepgupta/?hl=en

https://www.youtube.com/c/drsandeepgupta

https://x.com/drsandeepgupta

Support the Podcast

If you found this conversation valuable, consider subscribing and leaving a review on your preferred podcast platform. Your feedback helps us continue to bring you insightful discussions on important health topics.

Share this episode with someone who might benefit from these insights—because understanding integrative health can make all the difference.

00:18 Journey from Traditional to Integrative Medicine

02:12 Challenges in Holistic Medicine

07:01 Medicine 3.0: Healthspan vs. Lifespan

08:44 Longevity Programs and Initial Assessments

14:02 Metabolic Syndrome and Insulin Resistance

21:23 The Challenge of Reversing Long-Term Health Issues

21:28 Diet Recommendations for Longevity

23:58 The Importance of Protein and Muscle Mass

28:43 Inflammation and Longevity

34:21 The Role of Microbiome in Health

38:18 The Benefits of Nature and Grounding

See omnystudio.com/listener for privacy information.

See omnystudio.com/listener for privacy information.

Carly Taylor is a Mental Fitness Coach and Counsellor, helping people to strengthen their mental fitness and live with purpose. Her work is all about prevention, giving people the tools to manage their thoughts and emotions before they reach breaking point.

To find out more about Carly, visit www.carlytaylorcoaching.com.au.
Follow her on Instagram: carly_taylor_coaching

See omnystudio.com/listener for privacy information.

In this enlightening episode, I’m joined by Dr. Nathan Bryan to discuss the multifaceted role of nitric oxide in human health. Dr. Bryan, a pioneering scientist in nitric oxide research, offers an in-depth exploration of its function as a crucial signalling molecule, its impact on cardiovascular health, and its potential therapeutic applications for various diseases. Through this conversation, the importance of dietary choices, the dangers of common health misconceptions, and the power of simple lifestyle changes come to light.

What You'll Learn:

• Origins and Discovery: Learn about the groundbreaking discovery of nitric oxide as a signalling molecule in the cardiovascular system, a discovery that earned its pioneers a Nobel Prize.
• Physiological Roles: Understand how nitric oxide functions as a neurotransmitter and its significance in long-term memory and nerve communication.
• Connection to Diet: Discover the vital relationship between dietary nitrates, nitric oxide production, and the importance of a healthy microbiome.
• Impact of Lifestyle Choices: Explore how lifestyle choices, like diet and oral hygiene practices, can profoundly affect nitric oxide production and overall health.
• Current and Future Research: Gain insight into Dr. Bryan’s ongoing research into nitric oxide-based therapies for diseases like Alzheimer's and cardiovascular issues.

Key Takeaways:

• Diet and Health: Consuming a diet rich in green leafy vegetables can optimise nitric oxide production, supporting cardiovascular and immune health.
• Oral Hygiene: Antiseptic mouthwashes and fluoride toothpaste can disrupt the oral microbiome, negatively impacting nitric oxide production and raising blood pressure.
• The Microbiome's Role: A diverse and healthy microbiome supports nitric oxide production, critical for numerous bodily functions.
• Therapeutic Potential: Nitric oxide has the potential to revolutionise treatments for diseases like heart disease and Alzheimer’s.
• Holistic Health Approaches: Combining dietary changes, careful oral care, and appropriate supplements with conventional medical treatments can significantly enhance health outcomes.

Resources

• Discover more through Dr. Nathan Bryan’s book, "The Secret of Nitric Oxide: Bringing the Science to Life," available at major retailers.
• Explore Dr. Bryan's educational videos on YouTube to deepen your understanding of nitric oxide and its health impacts.
• Connect with Dr. Bryan on LinkedIn for ongoing insights and information.
• Connect with Dr. Bryan on Instagram
• Website: https://n1o1.com/about-dr-nathan-bryan/

Through this conversation, Dr. Bryan reveals that understanding and optimising nitric oxide production can play a significant role in improving health outcomes. By making informed lifestyle choices and staying updated with scientific advances, we can harness this powerful molecule for better health and longevity. If you're interested in health innovation and the body's complex biochemistry, this discussion is a must-listen.

Support the Podcast

If you found this conversation enriching and beneficial, subscribe, rate, and review us on your favourite podcast platform. Your support spreads these essential dialogues, offering more individuals the opportunity to embark on their healing journeys.

01:53 Understanding Nitric Oxide: Basics and Discoveries

02:49 Nitric Oxide in the Cardiovascular System

08:28 Nitric Oxide's Role in the Immune System

10:33 Nitric Oxide in Neurons and Brain Health

16:37 Diet, Microbiome, and Nitric Oxide Production

31:49 Impact of Medications on Nitric Oxide Production

42:29 Optimising Nitric Oxide Through Diet and Supplements

46:15 The Impact of Dental Hygiene on Nitric Oxide Production

46:37 The Controversy of Fluoride in Water and Toothpaste

48:48 The Dangers of Antiseptic Mouthwash

53:06 The Benefits of Tongue Scraping

54:05 Optimising Nitric Oxide Through Lifestyle Practices

56:26 The Science of Photo biomodulation and Infrared Saunas

59:00 The Debate Between Traditional and Infrared Saunas

01:02:40 Morning Routine for Optimal Health

01:04:45 Scepticism Around Biohacking Supplements

01:12:02 Exciting Future of Nitric Oxide Research

See omnystudio.com/listener for privacy information.