The Obesity Guide with Matthea Rentea MD

How to Handle a Medication Pause Without Losing Progress


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What do you do when you have to take a break from your GLP-1 medication—whether for a medical procedure, travel, or an unexpected setback? One patient recently wrote in, frustrated after going off their meds for a colonoscopy and feeling completely off track.

It’s easy to panic, feel like you've lost progress, or worry that getting back on track will be impossible. Your body’s natural instincts are working against you, and without a plan, you can quickly spiral into all-or-nothing thinking: I’ve blown it, so what’s the point?

In this episode, I break down the "ladder" approach to reintegration—starting with hydration, structured eating, and realistic goals—so you can ease back in without burnout. Because this isn’t just about bouncing back after a procedure; it’s about knowing how to plan for any time life throws you off course. 

Audio Stamps

00:00 - The April round of The 30/30 Program is now open for enrollment.

03:40 - Dr. Rentea reflects on a recent business retreat, emphasizing the importance of mind-body balance through practices like Qigong and sound baths

07:18 - Dr. Rentea shares a patient’s question about pausing their GLP-1 medication before a colonoscopy and how it can impact hunger, weight, and cravings.

09:27 - While off your medication, focus on drinking water, eating protein, and managing cravings. Hunger and weight gain are temporary—things will even out once you're back on track.

13:52 - Use a ladder approach to get back on track: start with hydration, add protein and fiber, then focus on structured meals. 

16:00 - This period is a powerful reminder of how much support the medication provides. Use it as motivation to stay consistent with nutrition and habits.

Quotes

“I don't even care if some weight comes back because here's the first thing I want you to realize: These medications are incredibly anti-inflammatory.”

“I would try to really make sure that you're hitting hydration and protein. Those would be the two that I would really focus on.”

“You're going to do the best you can. It's not going to be perfect. You're going to get that procedure and then afterward, you're going to get back on track.”

“You're not going to be scared by how quickly your hunger comes back because remember, it is super hard to keep fat off. Our body always wants to fight us.”

“You're going to try to hold on the best you can. You're going to try to do the things you can do that are allowed by the physician prior. And then afterward, you're going to ease yourself back in with simple steps. And you're going to al

All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.

If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.com

Premium Season 1 of The Obesity Guide: Behind the Curtain -Dive into real clinical scenarios, from my personal medication journey to tackling weight loss plateaus, understanding insulin resistance, and challenges with GLP-1s. Plus, get a 40+ page guide packed with protein charts, weight loss formulas, and more. 

Pre-register for the Sep 30/30 group.

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The Obesity Guide with Matthea Rentea MDBy Matthea Rentea MD

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