On episode #40 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 10/13 – 10/25/23.

Host: Daniel Griffin and Sara Dong

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• Sustained viral suppression with dolutegravir monotherapy over 192 weeks in patients starting combination antiretroviral therapy during primary HIV infection (CID)
• Dolutegravir monotherapy possibly boosted by highly active natural immunity (CID)
• Mpox neutralizing antibodies at 6 months from mpox infection or MVA-BN vaccination (The Lancet)
• Linezolid population pharmacokinetic model in plasma and cerebrospinal fluid among patients with tuberculosis meningitis (JID)
• Adjunctive dexamethasone for tuberculous meningitis in HIV-positive adults (NEJM)
• Cefepime vs piperacillin-tazobactam in adults hospitalized with acute infection (JAMA)
• Acute kidney injury with empirical antibiotics for sepsis (JAMA)
• Mycobacterium abscessus outbreak related to contaminated water among ventilator-dependent residents of a pediatric facility (CDC)
• Trial of Vancomycin and Cefazolin as surgical prophylaxis in arthroplasty (NEJM)
• Trimethoprim-sulfamethoxazole significantly reduces the risk of nocardiosis in solid organ transplant recipients (CMI)
• Risk of hematologic cancers among individuals tested for Borrelia burgdorferi antibodies, and Borrelia burgdorferi seropositive individuals (CMI)
• In vitro susceptibility patterns for slowly growing non-tuberculous mycobacteria (JAC)
• Real-world use of mold-active triazole prophylaxis in the prevention of invasive fungal diseases (OFID)
• Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19 (INI)
• Real-time dermoscopy of numerous mites crawling on the crusted scabies (CMI)
• The African eye worm: current understanding of the epidemiology, clinical disease, and treatment of loiasis (The Lancet)
• Decolonization in nursing homes to prevent infection and hospitalization (NEJM)
• Can chatbot artificial intelligence replace ID physicians in the management of bloodstream infections (CID)
• Nasal iodophor antiseptic vs nasal mupirocin antibiotic in the setting of chlorhexidine bathing to prevent infections in ICUs (JAMA)
• FDA Approves PENBRAYATM for the prevention of the five most common serogroups causing meningococcal disease in adolescents (Pfizer)

Music is by Ronald Jenkees