The immune system works tirelessly to maintain health and well-being. This formidable defense mechanism is comprised of a vast array of cells, tissues, proteins, and molecules that work together to identify and neutralize foreign invaders. The inflammation that ensues can be recognized by redness, pain, swelling, and heat. In order for this process to take place, the body needs to be able to identify what is ‘friend or foe’. But how? There are certain molecular patterns that our immune system recognizes as part of this surveillance and recognition. Some patterns are associated with pathogens - “pathogen-associated molecular patterns” (PAMPs). Others are associated with damaged cells (DAMPs) or lifestyle choices (LAMPs).  

In today’s episode, we do a quick refresher on adaptive and innate immunity. We also discuss some signaling molecules that trigger the inflammatory cascade – PAMPs, DAMPs, and LAMPs.

Today on The Lab Report:

• 3:40 Break it down – innate vs. adaptive immunity
• 6:40 Pathogen-associated molecular patterns (PAMPs), Pattern Recognition Receptors (PRRs)
• 10:25 Sterile inflammation: damage-associated molecular patterns (DAMPs)
• 14:30 Lifestyle-associated molecular patterns (LAMPs) & chronic inflammation
• 18:25 Question of the Day
  • How do we turn off the LAMPs?

Additional Resources:

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