We can enhance athletic performance, lose weight with a pill and even take psychedelics to alter consciousness. At what point does all this self-optimization become self-obsession? When does it get in the way of our humanity itself? My guest this week is the German biotech entrepreneur Christian Angermayer, who believes scientific breakthroughs to extend our lives — and even put us in touch with the divine — are close at hand.

0:00 - Intro

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Read the full transcript here: https://www.nytimes.com/2026/06/11/opinion/better-sex-better-hair-better-sleep-humanmaxxing-is-here.html

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In an era defined by deep institutional distrust, a new trend within populist conservatism has emerged. It’s a sense that the federal government is keeping secrets and protecting the powerful at our expense. My guest this week is Representative Anna Paulina Luna, a conservative Republican from Florida who has quickly established herself as a political troublemaker. She’s challenging fellow lawmakers — Republicans and Democrats — on issues like sexual harassment and ethics, but she doesn’t see her campaign to clean up Congress as in tension with her allegiance to President Trump. Luna has focused her first years in Congress on exposing what she views as coverups, from the Epstein files to the assassination of John F. Kennedy and longstanding government secrecy around U.F.O.s.

(A full transcript of this episode is available on the Times website.)

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The future of high-tech warfare has arrived. Just look to the conflicts in Ukraine and Iran to see how much drones and robots have remade the modern battlefield. Is the U.S. positioned to win wars in this new era? What are the ethical constraints of waging autonomous warfare? My guest this week is Christian Brose, the president and chief strategy officer of Anduril, a defense technology company building a slate of autonomous weapons and defense systems for the American military.

(A full transcript of this episode is available on the Times website.)

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What’s really driving the humanities crisis in higher education? As enrollment and reading decline, I asked Jennifer Frey, a professor of philosophy, what it was like to run a liberal arts program that was gutted. I wanted to know whether she thinks the age of A.I. could bring back the kind of education she says is fundamental to human formation.

(A full transcript of this episode is available on the Times website.)

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The United States and China are really the only two countries that matter right now in shaping the A.I. future. As President Trump and President Xi Jinping meet in Beijing, there’s a kind of Cold War atmosphere, with people talking about an A.I. arms race. But who is winning? Are we even in a race at all? Kyle Chan, a foreign policy fellow at the Brookings Institution, says it’s hard to call it a race because the U.S. and China have very different A.I. goals.

(A full transcript of this episode is available on the Times website.)

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A stalemated war. Fractured alliances. A rival waiting in the wings. It feels to me that we’re having an “end of the American empire” moment. My guest this week, Ray Dalio, is an unlikely prophet of doom — the billionaire Bridgewater investor conquered Wall Street by studying history and mastering global trends. He foresaw the 2008 financial crisis,and these days he’s warning that the U.S. is repeating the patterns that ended great empires of the past.

(A full transcript of this episode is available on the Times website.)

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Self-driving cars are here. But what kind of future will they bring: safe roads and extra time or dystopian traffic jams? My guest this week is Andrew Miller, who writes about self-driving cars and transportation policy. I love the open road, so I press him on what’s lost when we give away driving to the robots.

(A full transcript of this episode is available on the Times website.)

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One question has haunted my investment strategy for years: What is cryptocurrency actually for? It feels as though the vibes are constantly shifting — one day it’s the dollar’s successor, and the next it’s little more than a meme. My guest this week is bitcoin evangelist Anthony Pompliano, the chief executive of ProCap Financial. We get into whether crypto is a bet against the American empire and whether its volatility is actually a strength.

(A full transcript of this episode is available on the Times website.)

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President Trump has tested the limits of presidential power since he returned to office — from his assertion of total control over federal agencies to his war in Iran. But so far, many of Trump’s most aggressive moves have been stopped by the Supreme Court. 

My guest this week is Sarah Isgur, a conservative court watcher, who argues that the Supreme Court isn’t just a firewall against Donald Trump, but the real power center in American politics today.

(A full transcript of this episode is available on the Times website.)

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How would you live if you knew when you were going to die? I sat down with the former Republican senator Ben Sasse to hear how he is facing his own mortality after receiving a terminal cancer diagnosis. For Sasse, cancer brings pain, but also clarity, sharpening his focus on the state of our politics, his wife and three children, and the God he expects to shortly meet.

(A full transcript of this episode is available on the Times website.)

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