March 13, 2026

John E. Lewis, Ph.D. - The Polysaccharide Breakthrough for Brain Health and Alzheimer’s

47 minutes

What if the nutrients modern diets ignore are the very ones your brain and immune system desperately need?

In this episode of The Dr. K Show, Dr. K sits down with nutritional researcher John E. Lewis, Ph.D., founder of Dr Lewis Nutrition® and lead investigator of a groundbreaking clinical trial on polysaccharides from aloe vera and rice bran. Dr. Lewis explains why the war on “all sugar” is scientifically flawed and why certain complex sugars may play a crucial role in immune intelligence, cellular communication, and brain health.

The conversation explores his University of Miami research showing improvements in cognitive function in people with moderate to severe Alzheimer’s disease, along with increases in adult stem cells and improved immune markers. Dr. Lewis also exposes why nutrition research often receives little funding compared to pharmaceuticals, the science behind polysaccharides and cellular communication, and why extreme diets like keto and carnivore may miss critical components of human biology.

If you want to understand how nutrition, immune modulation, and complex carbohydrates influence brain health and aging, this episode will change the way you think about food and supplements.

Key Takeaways:

0:00 Introduction

3:20 How bodybuilding sparked a lifelong focus on nutrition science

6:30 The discovery of aloe vera polysaccharides and Alzheimer’s research

12:10 Why nutrition research receives little funding compared to drugs

16:45 The science of polysaccharides and cellular communication

21:40 Alzheimer’s findings: immune balance, stem cells, and cognitive improvement

27:10 Why Alzheimer’s disease is more complex than plaque and tangles

31:15 The gut microbiome connection and polysaccharide prebiotic effects

36:00 Why keto and carnivore diets may miss critical nutrients

41:10 The creation of Daily Brain Care and future of polysaccharide research

Resources Mentioned:

Dr Lewis Nutrition - https://drlewisnutrition.com/

Journal of Alzheimer’s Disease - https://www.j-alz.com/

University of Miami - https://www.miami.edu/

Medical Disclaimer: This content is for educational purposes only and is not intended to diagnose, treat, cure, or replace professional medical advice. Always consult your physician or qualified healthcare provider regarding any medical condition or treatment decisions.

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By Dr. Michael Karlfeldt

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