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What if one of the most powerful tools for slowing biological aging has been hiding in plain sight for decades?

This week on The Daily Apple, Dr. Brad Younggren joins us to unpack therapeutic plasma exchange (TPE) and why it could be a game-changer for longevity. Dr. Younggren is an emergency medicine physician, U.S. Army combat veteran, and now CEO and co-founder of Circulate Health
. Under his leadership, Circulate has completed more than a thousand treatments across 24 clinics and published data showing an average 2.6-year slowdown in biological aging.

“Therapeutic plasma exchange isn’t just for rare hospital cases anymore. We’re learning it can lower inflammation, clear out harmful proteins, and even reduce microplastics — all things tied to how fast we age.” — Dr. Brad Younggren

We talk about:

• What TPE actually is (and how it differs from a blood donation).
• Results from the Circulate Trial and why they matter.
• How plasma exchange impacts inflammation, senescent cells, and lipids.
• Early research on microplastics and cognitive decline.
• Why partnerships with clinics may be the fastest path to making longevity care more accessible.

Dr. Younggren also shares his own journey from combat medicine to pioneering new frontiers in healthspan, and where he sees longevity breakthroughs heading in the next decade.

🎙️ Listen now to learn how medicine, technology, and patient care are converging to help us live healthier, longer lives.

Takeaways

1. Therapeutic plasma exchange (TPE) uses established hospital technology in new ways to target aging and inflammation.
2. Clinical data from the Circulate Trial showed an average 2.6-year slowdown in biological aging after six treatments.
3. TPE may help reduce markers of inflammation, senescent cells, and even microplastics in the body.
4. Circulate Health partners with existing clinics instead of building its own, making the treatment more accessible.
5. Longevity medicine is moving fast — but staying grounded in rigorous science and real patient data is essential.

Prime Health Associates