For this Hot Topic episode, Prof. Tiago Outeiro talks with Dr. Briana de Miranda about the basic science behind the relationship between pesticides and Parkinson's disease. Together they discuss the possible mechanistic action of these products and how dopaminergic neurons are more susceptible.

Prof. Daniela Berg joins Prof. Tiago Outeiro in this first Hot Topic episode focusing on pesticides and Parkinson’s disease (PD). Together they discuss the rise of PD, the impact of pesticides, and what should be done to safeguard people from potential harm.

Dr. Sara Schaefer interviews Dr. Roberto Erro on the phenotypic characteristics of essential tremor, essential tremor with soft dystonic signs, and tremor combined with dystonia through analysis of The Italian tremor Network (TITAN) data.

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Dr. Sarah Camargos interviews Dr. Giovanna Zorzi on the outcomes of a cohort of non-degenerative pediatric patients with idiopathic and genetic dystonia who were submitted to GPi-DBS and compares these outcomes with a meta-analysis of the literature.

Journal CME is available until July 24, 2025

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Studies have shown a close interplay between the cerebrovascular system and neurodegeneration. But what is the current evidence, and how can it help us better understand the pathophysiology of Lewy body disorders and potentially change their course? In this episode, Dr. Michele Matarazzo interviews Prof. Sephira Ryman about a recently published review article that explores the complexities of this relationship.

Journal CME is available until August 21, 2025

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In this episode, Dr. Joseph Seemiller and Dr. Kelly Mills discuss the changes in cognitive performance in the OFF and ON states during an acute levodopa challenge in a large cohort of patients with Parkinson's disease. Their study's findings suggest divergent complex changes in processing speed and executive function.

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In this episode, Drs. Gandolfi and Tinazzi discuss how virtual reality can be used as a therapeutic tool to modulate attention in patients with functional motor disorder, while measuring postural control.

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Prof. Rob de Bie joins Dr. Sara Schaefer to discuss the 5-year follow up extension to the Levodopa in Early Parkinson's disease (LEAP) study, including the results and indications for practice.

Journal CME is available until July 01, 2025

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Dr. Gennaro Pagano discusses the findings of the post-hoc analysis of the PASADENA trial, a study using the monoclonal antibody Prasinezumab directed at aggregated α-synuclein, where motor progression trajectories differed between active and placebo groups. Read article »

Dr. Eduardo Fernández and Dr. Daniel Weintraub discuss whether subjective cognitive complaints can predict future incident cognitive impairment and other questions related to early cognitive impairment in people with Parkinson's disease, referencing Dr. Weintraub’s recent article, "Association between subjective cognitive complaints and incident functional impairment in Parkinson's disease" published in Movement Disorders. Read article »